SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gtx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 11 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.98A 1c9sP-2gtxA:
undetectable
1c9sQ-2gtxA:
undetectable		 1c9sP-2gtxA:
18.59
1c9sQ-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.98A 1gtfJ-2gtxA:
undetectable
1gtfK-2gtxA:
undetectable		 1gtfJ-2gtxA:
18.59
1gtfK-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 11 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.97A 1gtfQ-2gtxA:
undetectable
1gtfR-2gtxA:
undetectable		 1gtfQ-2gtxA:
18.59
1gtfR-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 11 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.95A 1gtfS-2gtxA:
undetectable
1gtfT-2gtxA:
undetectable		 1gtfS-2gtxA:
18.59
1gtfT-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 11 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.98A 1gtnT-2gtxA:
undetectable
1gtnU-2gtxA:
undetectable		 1gtnT-2gtxA:
18.59
1gtnU-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.97A 1gtnL-2gtxA:
undetectable
1gtnV-2gtxA:
undetectable		 1gtnL-2gtxA:
18.59
1gtnV-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 ASP A 253
THR A 255
GLU A 131
 None
 0.82A 1pj7A-2gtxA:
undetectable		 1pj7A-2gtxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 VAL A  16
ALA A  17
HIS A 106
 None
 0.71A 1q23C-2gtxA:
undetectable		 1q23C-2gtxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 VAL A  16
ALA A  17
HIS A 106
 None
 0.70A 1q23H-2gtxA:
undetectable		 1q23H-2gtxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 VAL A  16
ALA A  17
HIS A 106
 None
 0.74A 1q23L-2gtxA:
undetectable		 1q23L-2gtxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 VAL A  16
ALA A  17
HIS A 106
 None
 0.71A 1q23J-2gtxA:
undetectable		 1q23J-2gtxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 1.00A 1utdE-2gtxA:
undetectable
1utdF-2gtxA:
undetectable		 1utdE-2gtxA:
18.59
1utdF-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.99A 1utdH-2gtxA:
undetectable
1utdI-2gtxA:
undetectable		 1utdH-2gtxA:
18.59
1utdI-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.91A 1utdL-2gtxA:
undetectable
1utdM-2gtxA:
undetectable		 1utdL-2gtxA:
18.59
1utdM-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.96A 1utdO-2gtxA:
undetectable
1utdP-2gtxA:
undetectable		 1utdO-2gtxA:
18.59
1utdP-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 11 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.96A 1utdS-2gtxA:
undetectable
1utdT-2gtxA:
undetectable		 1utdS-2gtxA:
18.59
1utdT-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 11 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.94A 1utdL-2gtxA:
undetectable
1utdV-2gtxA:
undetectable		 1utdL-2gtxA:
18.59
1utdV-2gtxA:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		6 / 7 CYH A  59
TYR A  62
TYR A  65
CYH A  70
HIS A  79
HIS A 178
 NLP  A3808 ( 3.8A)
NLP  A3808 ( 4.8A)
NLP  A3808 ( 4.0A)
NLP  A3808 ( 3.7A)
NLP  A3808 (-3.8A)
NLP  A3808 (-3.9A)
 0.60A 1yvmA-2gtxA:
47.9		 1yvmA-2gtxA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		6 / 7 CYH A  59
TYR A  65
CYH A  70
HIS A  79
HIS A 178
TRP A 221
 NLP  A3808 ( 3.8A)
NLP  A3808 ( 4.0A)
NLP  A3808 ( 3.7A)
NLP  A3808 (-3.8A)
NLP  A3808 (-3.9A)
None
 0.58A 1yvmA-2gtxA:
47.9		 1yvmA-2gtxA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 PHE A 201
ILE A 144
LEU A 195
GLY A 150
VAL A 140
 None
 0.92A 3rukB-2gtxA:
undetectable		 3rukB-2gtxA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 8 ILE A 203
GLU A 148
LEU A 195
VAL A 193
 None
 0.82A 3ua5A-2gtxA:
undetectable		 3ua5A-2gtxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 8 SER A 188
GLU A 190
ILE A 214
VAL A 223
 None
 0.94A 4dx7B-2gtxA:
undetectable		 4dx7B-2gtxA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 8 VAL A 115
TYR A  31
ILE A  44
VAL A  69
 None
 0.90A 4ma7A-2gtxA:
undetectable		 4ma7A-2gtxA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 SER A 110
MET A 112
ASP A  42
 None
 0.93A 4mm4B-2gtxA:
undetectable		 4mm4B-2gtxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 ALA A  58
GLY A 107
THR A 237
LEU A 248
GLY A 174
 None
 1.20A 4n48B-2gtxA:
undetectable		 4n48B-2gtxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 6 ASP A 108
ALA A  17
THR A 237
THR A 249
 MN  A   1 ( 2.8A)
None
None
None
 1.46A 4z4iA-2gtxA:
undetectable		 4z4iA-2gtxA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 4 LEU A 133
ILE A 256
ARG A 251
TYR A 134
 None
 1.44A 4zzbA-2gtxA:
0.0		 4zzbA-2gtxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 4 LEU A 133
ILE A 256
ARG A 251
TYR A 134
 None
 1.48A 4zzcA-2gtxA:
undetectable		 4zzcA-2gtxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 4 LEU A 133
ILE A 256
ARG A 251
TYR A 134
 None
 1.46A 4zzcB-2gtxA:
0.0		 4zzcB-2gtxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.98A 5eevA-2gtxA:
undetectable
5eevB-2gtxA:
undetectable		 5eevA-2gtxA:
18.59
5eevB-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.99A 5eewA-2gtxA:
undetectable
5eewB-2gtxA:
undetectable		 5eewA-2gtxA:
18.59
5eewB-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.98A 5eexA-2gtxA:
undetectable
5eexB-2gtxA:
undetectable		 5eexA-2gtxA:
18.59
5eexB-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.98A 5eeyA-2gtxA:
undetectable
5eeyB-2gtxA:
undetectable		 5eeyA-2gtxA:
18.59
5eeyB-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.98A 5eezA-2gtxA:
undetectable
5eezB-2gtxA:
undetectable		 5eezA-2gtxA:
18.59
5eezB-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.99A 5ef0A-2gtxA:
undetectable
5ef0B-2gtxA:
undetectable		 5ef0A-2gtxA:
18.59
5ef0B-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.98A 5ef1A-2gtxA:
undetectable
5ef1B-2gtxA:
undetectable		 5ef1A-2gtxA:
18.59
5ef1B-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.99A 5ef2A-2gtxA:
undetectable
5ef2B-2gtxA:
undetectable		 5ef2A-2gtxA:
18.59
5ef2B-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.98A 5ef3A-2gtxA:
undetectable
5ef3B-2gtxA:
undetectable		 5ef3A-2gtxA:
18.59
5ef3B-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 ILE A 149
GLY A 150
VAL A 164
ALA A 136
ILE A 238
 None
 1.03A 5n0tB-2gtxA:
undetectable		 5n0tB-2gtxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 7 GLY A 170
HIS A 171
ASP A 108
HIS A  79
 None
MN  A   1 ( 3.8A)
MN  A   1 ( 2.8A)
NLP  A3808 (-3.8A)
 0.63A 5nnwD-2gtxA:
undetectable		 5nnwD-2gtxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 7 GLY A 170
HIS A 171
ASP A 108
HIS A  79
 None
MN  A   1 ( 3.8A)
MN  A   1 ( 2.8A)
NLP  A3808 (-3.8A)
 0.64A 5no9D-2gtxA:
undetectable		 5no9D-2gtxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 6 ASN A 208
ALA A 209
VAL A 207
ASP A 227
 None
 1.17A 5umd2-2gtxA:
undetectable
5umdF-2gtxA:
undetectable		 5umd2-2gtxA:
14.62
5umdF-2gtxA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2gtx METHIONINE
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 VAL A 164
LEU A 195
VAL A 140
THR A 202
GLY A 170
 None
None
None
MN  A   1 ( 3.7A)
None
 1.41A 6brdA-2gtxA:
undetectable		 6brdA-2gtxA:
16.16