SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		3 / 3 ALA A 214
VAL A 262
TRP A 266
 None
 0.89A 1bdwA-2gu0A:
undetectable
1bdwB-2gu0A:
undetectable		 1bdwA-2gu0A:
4.12
1bdwB-2gu0A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		3 / 3 ALA A 203
VAL A 262
TRP A 223
 None
 0.90A 1c4dA-2gu0A:
undetectable
1c4dB-2gu0A:
undetectable		 1c4dA-2gu0A:
4.12
1c4dB-2gu0A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		3 / 3 TRP A 223
ALA A 203
VAL A 262
 None
 0.78A 1c4dA-2gu0A:
undetectable
1c4dB-2gu0A:
undetectable		 1c4dA-2gu0A:
4.12
1c4dB-2gu0A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 10 VAL A   8
LEU A 115
GLU A 112
LEU A 111
VAL A 106
 None
 0.99A 1cqpA-2gu0A:
undetectable
1cqpB-2gu0A:
undetectable		 1cqpA-2gu0A:
22.78
1cqpB-2gu0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 8 LEU A  79
VAL A   8
LEU A   4
ALA A   2
 None
 0.87A 1fiqC-2gu0A:
undetectable		 1fiqC-2gu0A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		3 / 3 THR A 148
THR A 152
PRO A 150
 None
 0.86A 1fjaC-2gu0A:
undetectable		 1fjaC-2gu0A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		3 / 3 THR A 148
THR A 152
PRO A 150
 None
 0.86A 1fjaD-2gu0A:
undetectable		 1fjaD-2gu0A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 7 GLU A 112
LEU A 111
VAL A 136
LEU A 125
 None
 0.65A 1hk3A-2gu0A:
undetectable		 1hk3A-2gu0A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 8 LEU A 179
GLU A 183
HIS A 234
ALA A 181
 None
 0.98A 2bnnA-2gu0A:
undetectable
2bnnB-2gu0A:
undetectable		 2bnnA-2gu0A:
20.56
2bnnB-2gu0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 6 ASP A 170
LEU A 179
ASP A 182
LEU A 227
 None
 1.27A 3bj8C-2gu0A:
undetectable
3bj8D-2gu0A:
undetectable		 3bj8C-2gu0A:
20.06
3bj8D-2gu0A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_2
(GLUCOCORTICOID
RECEPTOR)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 5 ASN A 189
TRP A 223
MET A 259
TYR A 159
 None
 1.42A 3h52D-2gu0A:
0.0		 3h52D-2gu0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 4 ILE A 188
PHE A 164
ILE A 194
THR A 149
 None
 0.96A 3ia4A-2gu0A:
undetectable		 3ia4A-2gu0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 8 SER A 285
THR A 268
LEU A 273
ALA A 235
 None
 1.01A 3ns1L-2gu0A:
undetectable		 3ns1L-2gu0A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		3 / 3 ARG A  60
PRO A  54
PHE A  61
 None
 0.95A 3thrC-2gu0A:
undetectable		 3thrC-2gu0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 12 LEU A 111
ASP A  70
ILE A  22
VAL A 106
VAL A 108
 None
 0.97A 3ucbA-2gu0A:
undetectable		 3ucbA-2gu0A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 12 LEU A 111
ASP A  70
ILE A  22
VAL A 106
VAL A 108
 None
 0.97A 3ucbB-2gu0A:
undetectable		 3ucbB-2gu0A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 7 THR A 187
LEU A 125
LYS A 119
ASN A 155
 None
 1.05A 4ib4A-2gu0A:
undetectable		 4ib4A-2gu0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 7 TYR A  67
ASN A 173
TYR A 171
GLU A 112
 None
 1.23A 4mi4A-2gu0A:
undetectable
4mi4C-2gu0A:
undetectable		 4mi4A-2gu0A:
20.39
4mi4C-2gu0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 11 ILE A 206
ALA A 201
PHE A 261
ILE A 188
TYR A 159
 None
 1.17A 4qlfA-2gu0A:
undetectable		 4qlfA-2gu0A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 12 LEU A  83
LEU A 142
ASN A 141
LYS A   2
ILE A 101
 None
 1.08A 5itzB-2gu0A:
undetectable		 5itzB-2gu0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 12 LEU A 273
ILE A 270
GLY A 265
ILE A 216
ALA A 215
 None
 1.16A 5j7wC-2gu0A:
undetectable		 5j7wC-2gu0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		3 / 3 THR A 152
HIS A 110
ASN A 113
 None
 0.84A 5n4tA-2gu0A:
undetectable		 5n4tA-2gu0A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		4 / 7 THR A 187
LEU A 125
LYS A 119
ASN A 155
 None
 1.04A 5tudA-2gu0A:
undetectable		 5tudA-2gu0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 12 ILE A 206
ALA A 201
PHE A 261
ILE A 188
TYR A 159
 None
 1.19A 5z6fA-2gu0A:
undetectable		 5z6fA-2gu0A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		3 / 3 LEU A  69
ASN A 141
LEU A  83
 None
 0.71A 6exiA-2gu0A:
undetectable		 6exiA-2gu0A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 12 LEU A 273
ILE A 270
GLY A 265
ILE A 216
ALA A 215
 None
 1.20A 6qxsD-2gu0A:
undetectable		 6qxsD-2gu0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 12 LEU A 273
ILE A 270
GLY A 265
ILE A 216
ALA A 215
 None
 1.20A 6qyaB-2gu0A:
undetectable		 6qyaB-2gu0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2gu0 NONSTRUCTURAL
PROTEIN 2
(Rotavirus
C) 		5 / 12 LEU A 273
ILE A 270
GLY A 265
ILE A 216
ALA A 215
 None
 1.18A 6qyaD-2gu0A:
undetectable		 6qyaD-2gu0A:
21.48