SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		4 / 8 HIS A  20
HIS A 183
TYR A 287
PHE A 281
 ZN  A 601 (-3.3A)
None
None
None
 1.34A 1eqbA-2gu2A:
undetectable
1eqbB-2gu2A:
undetectable		 1eqbA-2gu2A:
21.05
1eqbB-2gu2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		4 / 8 TYR A 287
PHE A 281
HIS A  20
HIS A 183
 None
None
ZN  A 601 (-3.3A)
None
 1.33A 1eqbA-2gu2A:
undetectable
1eqbB-2gu2A:
undetectable		 1eqbA-2gu2A:
21.05
1eqbB-2gu2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		4 / 8 TYR A 287
PHE A 281
HIS A  20
HIS A 183
 None
None
ZN  A 601 (-3.3A)
None
 1.32A 1eqbC-2gu2A:
undetectable
1eqbD-2gu2A:
undetectable		 1eqbC-2gu2A:
21.05
1eqbD-2gu2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		5 / 9 TYR A 287
ASN A  69
HIS A  20
GLU A  23
HIS A 115
 None
None
ZN  A 601 (-3.3A)
ZN  A 601 (-2.0A)
ZN  A 601 (-3.4A)
 1.42A 2bnnA-2gu2A:
0.0
2bnnB-2gu2A:
undetectable		 2bnnA-2gu2A:
20.81
2bnnB-2gu2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		4 / 8 THR A  31
GLY A  26
THR A  52
ILE A  51
 None
 0.95A 2f9wA-2gu2A:
undetectable
2f9wB-2gu2A:
undetectable		 2f9wA-2gu2A:
20.37
2f9wB-2gu2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		3 / 3 LEU A  68
LEU A  85
PHE A  72
 None
 0.73A 2pgrA-2gu2A:
undetectable		 2pgrA-2gu2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		5 / 11 VAL A 178
ILE A  15
PRO A  49
LEU A 198
ILE A 176
 None
 0.96A 3clbA-2gu2A:
undetectable		 3clbA-2gu2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		5 / 12 VAL A 178
ILE A  15
PRO A  49
LEU A 198
ILE A 176
 None
 0.97A 3clbC-2gu2A:
undetectable		 3clbC-2gu2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		5 / 10 VAL A 178
ILE A  15
PRO A  49
LEU A 198
ILE A 176
 None
 0.92A 3hbbA-2gu2A:
undetectable		 3hbbA-2gu2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		5 / 11 VAL A 178
ILE A  15
PRO A  49
LEU A 198
ILE A 176
 None
 1.00A 3hbbC-2gu2A:
undetectable		 3hbbC-2gu2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		5 / 11 ASP A 248
VAL A 260
PRO A 279
TYR A 222
LEU A 254
 None
 1.20A 3v8vB-2gu2A:
undetectable		 3v8vB-2gu2A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		4 / 6 CYH A  60
THR A  61
ASN A  22
GLY A 184
 None
SO4  A 703 (-3.8A)
None
None
 1.28A 3w9tE-2gu2A:
undetectable		 3w9tE-2gu2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		3 / 3 LEU A 149
PRO A 150
ARG A 187
 None
 0.68A 4klrB-2gu2A:
3.2		 4klrB-2gu2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		3 / 3 SER A 309
ASP A 109
ASP A 106
 None
 0.91A 4mwzA-2gu2A:
undetectable		 4mwzA-2gu2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		3 / 3 SER A 309
ALA A   6
VAL A   5
 None
 0.61A 4o2bA-2gu2A:
undetectable		 4o2bA-2gu2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		4 / 4 ASP A 250
GLY A 179
PRO A 180
GLN A 193
 None
 1.05A 4oltA-2gu2A:
0.4		 4oltA-2gu2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		3 / 3 ARG A 232
ASP A 229
TYR A 288
 None
 0.87A 4yo9B-2gu2A:
undetectable		 4yo9B-2gu2A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2gu2 ASPA PROTEIN
(Rattus
norvegicus) 		4 / 4 ASN A 233
SER A 263
ALA A 239
VAL A 238
 None
 1.22A 5nm5A-2gu2A:
undetectable		 5nm5A-2gu2A:
21.60