SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2guh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 9 LEU A 104
TYR A 101
VAL A  23
GLY A  27
ALA A  26
 None
 1.26A 1pxxB-2guhA:
undetectable		 1pxxB-2guhA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 10 LEU A 104
TYR A 101
VAL A  23
GLY A  27
ALA A  26
 None
 1.27A 1pxxD-2guhA:
2.0		 1pxxD-2guhA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 7 MET A  93
ARG A 137
LEU A 134
VAL A 184
 None
 1.28A 2hrcA-2guhA:
undetectable		 2hrcA-2guhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		6 / 11 LEU A  53
GLY A  48
ALA A  47
ASP A  24
VAL A  23
ILE A  22
 None
 1.45A 3nu3B-2guhA:
undetectable		 3nu3B-2guhA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		6 / 9 LEU A  53
GLY A  48
ALA A  47
ASP A  24
VAL A  23
ILE A  22
 None
 1.43A 3nuoB-2guhA:
undetectable		 3nuoB-2guhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 4 LEU A  98
ALA A 158
PHE A  94
ASN A 107
 None
EDO  A 505 ( 4.9A)
EDO  A 505 (-3.8A)
None
 0.95A 3vaqA-2guhA:
undetectable		 3vaqA-2guhA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 10 GLY A  87
ALA A  95
VAL A  91
GLU A 174
VAL A 184
 None
 1.30A 4da7A-2guhA:
undetectable		 4da7A-2guhA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		6 / 9 LEU A  53
GLY A  48
ALA A  47
ASP A  24
VAL A  23
ILE A  22
 None
 1.44A 4rvjB-2guhA:
undetectable		 4rvjB-2guhA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		6 / 9 LEU A  53
GLY A  48
ALA A  47
ASP A  24
VAL A  23
ILE A  22
 None
 1.43A 4rvjD-2guhA:
undetectable		 4rvjD-2guhA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		3 / 3 LEU A 109
PHE A  71
ILE A 108
 None
 0.77A 5dzk1-2guhA:
undetectable
5dzkF-2guhA:
undetectable
5dzkM-2guhA:
undetectable		 5dzk1-2guhA:
0.95
5dzkF-2guhA:
24.69
5dzkM-2guhA:
22.94