SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2guu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 6 LEU A 188
LEU A 140
LEU A 293
LEU A 320
 None
 0.90A 1errA-2guuA:
undetectable		 1errA-2guuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2guu ODCASE
(Plasmodium
vivax) 		5 / 11 CYH A  37
ILE A  38
ALA A 337
VAL A  32
LEU A 157
 None
 1.23A 1n4hA-2guuA:
undetectable		 1n4hA-2guuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2guu ODCASE
(Plasmodium
vivax) 		3 / 3 LYS A 224
ILE A 292
THR A 194
 None
 0.60A 1rx3A-2guuA:
undetectable		 1rx3A-2guuA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 7 GLY A  92
HIS A 116
TYR A 112
PRO A 101
 None
 1.17A 1th6A-2guuA:
undetectable		 1th6A-2guuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 6 LEU A  36
TYR A 340
ILE A 327
GLY A 296
 None
 0.86A 2du8A-2guuA:
undetectable		 2du8A-2guuA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 6 LEU A  36
TYR A 340
ILE A 327
GLY A 296
 None
 0.87A 2du8B-2guuA:
undetectable		 2du8B-2guuA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 4 VAL A  62
PHE A 113
PHE A 114
VAL A 149
 None
 1.31A 3rv5C-2guuA:
undetectable
3rv5D-2guuA:
undetectable		 3rv5C-2guuA:
13.25
3rv5D-2guuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 8 ILE A  38
LEU A  36
VAL A 297
GLY A 298
 None
 0.86A 3w1wA-2guuA:
undetectable		 3w1wA-2guuA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2guu ODCASE
(Plasmodium
vivax) 		3 / 3 LYS A 224
ILE A 292
THR A 194
 None
 0.60A 4gh8A-2guuA:
undetectable		 4gh8A-2guuA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2guu ODCASE
(Plasmodium
vivax) 		3 / 3 LEU A  66
LEU A 160
ASN A 152
 None
 0.77A 4otwA-2guuA:
undetectable		 4otwA-2guuA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 4 ALA A 299
VAL A 297
GLY A 273
THR A 226
 UP6  A5203 ( 3.9A)
None
UP6  A5203 ( 4.9A)
UP6  A5203 (-3.0A)
 1.08A 4ubeA-2guuA:
2.6		 4ubeA-2guuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2guu ODCASE
(Plasmodium
vivax) 		3 / 3 HIS A 231
SER A 230
LYS A 224
 None
 1.12A 5os7A-2guuA:
undetectable		 5os7A-2guuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2guu ODCASE
(Plasmodium
vivax) 		3 / 3 LEU A 188
VAL A 147
ASP A 148
 None
 0.57A 5x23A-2guuA:
undetectable		 5x23A-2guuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2guu ODCASE
(Plasmodium
vivax) 		3 / 3 HIS A 231
SER A 230
LYS A 224
 None
 1.12A 6gmdB-2guuA:
undetectable		 6gmdB-2guuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 5 LEU A 351
ILE A  38
MET A 307
GLY A 311
 None
 0.96A 6hd6A-2guuA:
undetectable		 6hd6A-2guuA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 5 LEU A 351
ILE A 327
MET A 307
GLY A 311
 None
 0.99A 6hd6A-2guuA:
undetectable		 6hd6A-2guuA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2guu ODCASE
(Plasmodium
vivax) 		3 / 3 ASN A 152
PRO A  88
GLN A  93
 None
 0.88A 6jnhA-2guuA:
undetectable		 6jnhA-2guuA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2guu ODCASE
(Plasmodium
vivax) 		3 / 3 ASN A 152
PRO A  88
GLN A  93
 None
 0.87A 6jogA-2guuA:
undetectable		 6jogA-2guuA:
17.75