SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2guz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2guz MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM16
(Saccharomyces
cerevisiae) 		4 / 8 GLU B 111
ARG B 115
LEU B  71
GLU B  66
 None
 1.05A 1cmaA-2guzB:
undetectable
1cmaB-2guzB:
undetectable		 1cmaA-2guzB:
18.95
1cmaB-2guzB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2guz MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM14
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 138
HIS A 133
ILE A 154
 None
 0.70A 1s9pB-2guzA:
undetectable		 1s9pB-2guzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 2guz MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM14
MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM16
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 104
ASN A 155
ALA A 157
LEU B  97
 None
 1.11A 3t3sC-2guzA:
undetectable		 3t3sC-2guzA:
10.23