SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 359
HIS A 148
GLU A 460
GLY A 186
PHE A 461
 None
 1.42A 1d4fA-2gv9A:
undetectable		 1d4fA-2gv9A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 359
HIS A 148
GLU A 460
GLY A 186
PHE A 461
 None
 1.41A 1d4fB-2gv9A:
undetectable		 1d4fB-2gv9A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 359
HIS A 148
GLU A 460
GLY A 186
PHE A 461
 None
 1.39A 1d4fC-2gv9A:
undetectable		 1d4fC-2gv9A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 359
HIS A 148
GLU A 460
GLY A 186
PHE A 461
 None
 1.44A 1d4fD-2gv9A:
undetectable		 1d4fD-2gv9A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 585
GLY A 586
TYR A 399
GLY A 464
LEU A 598
 None
 1.13A 1fduA-2gv9A:
undetectable		 1fduA-2gv9A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		3 / 3 LEU A1003
PRO A1004
LEU A1007
 None
 0.50A 1hrkA-2gv9A:
undetectable		 1hrkA-2gv9A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 6 ASP A 615
TYR A 614
ASN A 522
GLU A 154
 None
 1.18A 1rjdA-2gv9A:
undetectable		 1rjdA-2gv9A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 6 ASP A 615
TYR A 614
ASN A 522
GLU A 154
 None
 1.16A 1rjdB-2gv9A:
undetectable		 1rjdB-2gv9A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 6 ASP A 615
TYR A 614
ASN A 522
GLU A 154
 None
 1.15A 1rjdC-2gv9A:
undetectable		 1rjdC-2gv9A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 933
LEU A 977
ALA A 987
ILE A 883
LEU A 893
 None
 1.09A 1tw4A-2gv9A:
undetectable		 1tw4A-2gv9A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 8 ARG A 785
ILE A 788
ARG A 789
ILE A 792
 None
 0.50A 2bu8A-2gv9A:
undetectable		 2bu8A-2gv9A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 6 VAL A 621
SER A 816
ARG A 620
LEU A 604
 None
 1.28A 2f8dA-2gv9A:
undetectable		 2f8dA-2gv9A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		3 / 3 VAL A 517
VAL A 521
ASP A 368
 None
 0.61A 2fumD-2gv9A:
undetectable		 2fumD-2gv9A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 9 LEU A1188
ILE A1192
PHE A1162
ALA A1169
LEU A1166
 None
 1.12A 2m9qA-2gv9A:
undetectable		 2m9qA-2gv9A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		3 / 3 LEU A1003
PRO A1004
LEU A1007
 None
 0.50A 2qd5B-2gv9A:
undetectable		 2qd5B-2gv9A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 10 THR A 463
GLY A 464
TYR A 465
GLY A 586
PRO A 594
 None
 1.30A 2y7pA-2gv9A:
undetectable		 2y7pA-2gv9A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 813
ILE A 619
ILE A 152
VAL A 149
TYR A 316
 None
 1.37A 3g8iA-2gv9A:
0.0		 3g8iA-2gv9A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		3 / 3 LEU A1003
PRO A1004
LEU A1007
 None
 0.53A 3hcrA-2gv9A:
undetectable		 3hcrA-2gv9A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		3 / 3 GLU A 342
HIS A 197
THR A 337
 None
 0.87A 3hkuA-2gv9A:
undetectable		 3hkuA-2gv9A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 7 TYR A 483
LEU A 390
ASP A 389
ALA A 384
 None
 1.18A 3rodD-2gv9A:
undetectable		 3rodD-2gv9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		3 / 3 LEU A1003
PRO A1004
LEU A1007
 None
 0.49A 3w1wB-2gv9A:
undetectable		 3w1wB-2gv9A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 5 TYR A 399
LEU A 397
LEU A 432
ARG A 430
 None
 1.42A 4em2A-2gv9A:
1.7		 4em2A-2gv9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 6 SER A 339
ASP A 340
ARG A 126
GLU A 460
 None
 1.07A 4eysA-2gv9A:
undetectable		 4eysA-2gv9A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 8 SER A 772
LEU A 774
CYH A 732
PHE A 733
 None
 1.15A 4j7uD-2gv9A:
undetectable		 4j7uD-2gv9A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 8 LEU A 475
LEU A 479
ILE A 467
VAL A 517
 None
 0.85A 4klaA-2gv9A:
undetectable		 4klaA-2gv9A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 4 ASN A 518
GLY A 491
ASP A 481
ASP A 488
 None
 1.16A 4n49A-2gv9A:
undetectable		 4n49A-2gv9A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 397
GLY A 586
GLN A 587
ARG A 430
ILE A 467
 None
 1.20A 4oktA-2gv9A:
undetectable		 4oktA-2gv9A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 5 HIS A 595
ILE A 613
ILE A 609
TYR A 614
 None
 0.78A 5dnuA-2gv9A:
undetectable		 5dnuA-2gv9A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 5 HIS A 595
ILE A 613
ILE A 609
TYR A 614
 None
 0.69A 5dnvA-2gv9A:
undetectable		 5dnvA-2gv9A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 9 ILE A 726
LEU A 731
ARG A 842
ILE A 840
GLY A 841
 None
 1.10A 5ifuB-2gv9A:
undetectable		 5ifuB-2gv9A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 9 ILE A 726
LEU A 731
THR A 836
ILE A 840
GLY A 841
 None
 1.16A 5ifuB-2gv9A:
undetectable		 5ifuB-2gv9A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 11 ASN A 730
VAL A 258
SER A 734
THR A 735
LEU A 636
 None
 1.28A 5jh7B-2gv9A:
undetectable		 5jh7B-2gv9A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 11 ASN A 730
VAL A 258
SER A 734
THR A 735
LEU A 636
 None
 1.26A 5jh7D-2gv9A:
undetectable		 5jh7D-2gv9A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 7 GLY A 497
PHE A 499
ASP A 488
ASN A 494
 None
 1.09A 5n5dB-2gv9A:
undetectable		 5n5dB-2gv9A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 529
LEU A 588
PRO A 594
GLY A 527
ASP A 524
 None
 1.14A 5nnaA-2gv9A:
undetectable		 5nnaA-2gv9A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 529
LEU A 588
PRO A 594
GLY A 527
ASP A 524
 None
 1.15A 5nnaB-2gv9A:
undetectable		 5nnaB-2gv9A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 529
LEU A 588
PRO A 594
GLY A 527
ASP A 524
 None
 1.13A 5nnaC-2gv9A:
undetectable		 5nnaC-2gv9A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 529
LEU A 588
PRO A 594
GLY A 527
ASP A 524
 None
 1.15A 5nnaD-2gv9A:
undetectable		 5nnaD-2gv9A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		5 / 9 ALA A 600
ILE A 528
ILE A 523
ILE A 613
ALA A 809
 None
 1.00A 5nunA-2gv9A:
undetectable		 5nunA-2gv9A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 5 VAL A 585
LEU A 397
CYH A 396
ASP A 471
 None
 1.25A 5vcvA-2gv9A:
0.0		 5vcvA-2gv9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		4 / 5 GLY A 489
ARG A 492
GLN A  63
MET A 162
 None
 1.27A 5zrfB-2gv9A:
2.3		 5zrfB-2gv9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2gv9 DNA POLYMERASE
(Human
alphaherpesvirus
1) 		3 / 3 GLY A 464
ASP A 471
ILE A 394
 None
 0.46A 6dgxB-2gv9A:
undetectable		 6dgxB-2gv9A:
5.20