SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2gvi CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 MET A 108
LEU A 111
SER A 112
 None
 0.30A 1ee2A-2gviA:
undetectable		 1ee2A-2gviA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2gvi CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 LEU A  91
PHE A 160
GLY A 159
TYR A  48
 None
 0.97A 1fapB-2gviA:
undetectable		 1fapB-2gviA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2gvi CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 GLY A  60
LEU A  87
SER A  51
GLY A  85
 UNL  A 400 ( 4.9A)
None
None
None
 0.73A 1jhvA-2gviA:
undetectable		 1jhvA-2gviA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 2gvi CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ARG A 104
ILE A 151
ILE A 143
MET A 108
TYR A  22
 ACY  A 407 ( 4.3A)
None
None
None
UNL  A 400 (-4.8A)
 0.96A 2azyA-2gviA:
undetectable		 2azyA-2gviA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2gvi CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ASN A 105
ILE A 151
MET A  25
 ACY  A 410 ( 3.5A)
None
None
 0.85A 2h42C-2gviA:
undetectable		 2h42C-2gviA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2gvi CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 HIS A 102
SER A  51
GLU A  52
 ZN  A 302 ( 3.0A)
None
None
 0.91A 3s8pA-2gviA:
undetectable		 3s8pA-2gviA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 2gvi CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 ILE A 136
LEU A 140
HIS A  18
ALA A 115
 None
None
ZN  A 300 (-3.1A)
None
 0.77A 4g77A-2gviA:
undetectable		 4g77A-2gviA:
21.23