SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gvk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 235
THR A 260
HIS A 194
LEU A 292
 None
ACY  A 327 ( 3.9A)
ACY  A 327 (-4.4A)
None
 1.16A 1d4fC-2gvkA:
undetectable		 1d4fC-2gvkA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 107
LEU A 108
VAL A  28
ILE A  27
 None
None
EDO  A 322 ( 4.5A)
None
 1.03A 1s9qA-2gvkA:
undetectable		 1s9qA-2gvkA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 276
THR A 272
PHE A 188
LEU A 302
 None
 1.09A 2wm3A-2gvkA:
undetectable		 2wm3A-2gvkA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A  56
PHE A 123
PHE A  48
ILE A 112
 None
 1.24A 2zseA-2gvkA:
undetectable		 2zseA-2gvkA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 127
PHE A 123
ILE A  52
ALA A  50
ALA A  46
 None
 1.22A 3mdtA-2gvkA:
undetectable		 3mdtA-2gvkA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 314
PHE A 303
LEU A 131
VAL A  41
TYR A 261
 None
 1.30A 3sp9A-2gvkA:
undetectable		 3sp9A-2gvkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 314
PHE A 303
LEU A 131
VAL A  41
TYR A 261
 None
 1.25A 3sp9B-2gvkA:
undetectable		 3sp9B-2gvkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  18
ILE A  25
SER A  65
PHE A  64
ALA A 114
 None
 1.06A 3sueA-2gvkA:
undetectable		 3sueA-2gvkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  69
ALA A  46
GLY A 315
ASN A  47
MET A  51
 None
 1.32A 3v3oB-2gvkA:
undetectable		 3v3oB-2gvkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_1
(ALPHA-GLUCOSIDASE)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ARG A 213
GLU A 220
GLU A 166
LYS A 242
GLU A 160
 None
 1.24A 5hqaA-2gvkA:
0.1		 5hqaA-2gvkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 THR A 268
TYR A 186
THR A 272
ARG A 245
 None
None
None
EDO  A 323 (-4.0A)
 1.39A 5tzoA-2gvkA:
undetectable		 5tzoA-2gvkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 235
THR A 260
HIS A 194
LEU A 292
 None
ACY  A 327 ( 3.9A)
ACY  A 327 (-4.4A)
None
 1.18A 6aphA-2gvkA:
undetectable		 6aphA-2gvkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  18
ILE A  25
SER A  65
PHE A  64
ALA A 114
 None
 1.07A 6c2mA-2gvkA:
undetectable		 6c2mA-2gvkA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  18
ILE A  25
SER A  65
PHE A  64
ALA A 114
 None
 1.06A 6c2mB-2gvkA:
undetectable		 6c2mB-2gvkA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A  69
THR A 301
VAL A 138
VAL A 189
 None
EDO  A 322 (-3.6A)
None
None
 0.82A 6czmD-2gvkA:
1.0
6czmF-2gvkA:
undetectable		 6czmD-2gvkA:
23.22
6czmF-2gvkA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2gvk HEME PEROXIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 235
THR A 260
HIS A 194
LEU A 292
 None
ACY  A 327 ( 3.9A)
ACY  A 327 (-4.4A)
None
 1.17A 6gbnB-2gvkA:
undetectable		 6gbnB-2gvkA:
22.25