SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 301
LEU A 287
LEU A 316
LEU A 329
 None
 0.98A 1dvtA-2gw1A:
undetectable
1dvtB-2gw1A:
undetectable		 1dvtA-2gw1A:
13.83
1dvtB-2gw1A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 303
ALA A 301
SER A 297
 None
 0.68A 1errB-2gw1A:
undetectable		 1errB-2gw1A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 290
TYR A 298
GLY A 262
PHE A 264
GLU A 334
 None
 1.44A 1iolA-2gw1A:
undetectable		 1iolA-2gw1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 291
LEU A 287
ILE A 338
TYR A 368
ILE A 367
 None
 1.43A 1q6iA-2gw1A:
undetectable		 1q6iA-2gw1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 302
LYS A 307
ARG A 310
 None
 1.05A 1ra8A-2gw1A:
undetectable		 1ra8A-2gw1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 293
GLU A 495
PRO A 465
ALA A 464
 None
 1.40A 2ejgB-2gw1A:
undetectable		 2ejgB-2gw1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 9 SER A 155
VAL A 151
LEU A 170
SER A 174
LEU A 189
 None
 1.49A 2j2pD-2gw1A:
undetectable
2j2pE-2gw1A:
undetectable		 2j2pD-2gw1A:
17.94
2j2pE-2gw1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 464
SER A 259
GLY A 504
GLU A 495
LEU A 498
 None
 1.10A 2zifA-2gw1A:
undetectable		 2zifA-2gw1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 359
GLU A 313
GLN A 315
ILE A 331
LEU A 283
 None
 1.11A 3datA-2gw1A:
undetectable		 3datA-2gw1A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 548
LYS A 536
ALA A 534
PRO A 539
 None
 1.10A 3gv1A-2gw1A:
undetectable
3gv1C-2gw1A:
undetectable		 3gv1A-2gw1A:
14.01
3gv1C-2gw1A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 548
LYS A 536
ALA A 534
PRO A 539
 None
 1.14A 3gv1A-2gw1A:
undetectable
3gv1B-2gw1A:
undetectable		 3gv1A-2gw1A:
14.01
3gv1B-2gw1A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 210
GLU A 177
LYS A 181
ASN A 176
 None
 1.47A 3kp6A-2gw1A:
0.0
3kp6B-2gw1A:
undetectable		 3kp6A-2gw1A:
16.96
3kp6B-2gw1A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 11 ASN A 212
ALA A 569
PHE A 565
THR A 583
ILE A 582
 None
 1.29A 3n23A-2gw1A:
undetectable		 3n23A-2gw1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 449
ILE A 431
ILE A 474
ALA A 441
TYR A 442
 None
 1.15A 3ohtA-2gw1A:
undetectable
3ohtB-2gw1A:
undetectable		 3ohtA-2gw1A:
23.08
3ohtB-2gw1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 8 ASN A 210
ALA A 185
ASP A 184
ASP A 188
PRO A 519
 None
 1.44A 4eyrB-2gw1A:
undetectable		 4eyrB-2gw1A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 6 SER A 535
ASP A 538
SER A 541
ARG A 540
 None
 1.14A 4eysA-2gw1A:
undetectable		 4eysA-2gw1A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 545
LEU A 571
ALA A 544
 None
 0.68A 4ikiA-2gw1A:
undetectable		 4ikiA-2gw1A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 SER A 365
ARG A 362
HIS A 335
 None
 0.90A 4mjwA-2gw1A:
undetectable
4mjwB-2gw1A:
undetectable		 4mjwA-2gw1A:
21.90
4mjwB-2gw1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 367
PHE A 341
LEU A 342
ILE A 338
PHE A 264
 None
 1.06A 5b8iC-2gw1A:
undetectable		 5b8iC-2gw1A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 MET A 551
GLN A 554
ARG A 209
 None
 0.66A 5ewzB-2gw1A:
4.8		 5ewzB-2gw1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 MET A 551
GLN A 554
ARG A 209
 None
 0.66A 5m35B-2gw1A:
4.8		 5m35B-2gw1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 MET A 551
GLN A 554
ARG A 209
 None
 0.70A 5m36A-2gw1A:
8.4		 5m36A-2gw1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 135
ASN A 123
LEU A 126
 None
 0.83A 6b58A-2gw1A:
4.4		 6b58A-2gw1A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 MET A 551
GLN A 554
ARG A 209
 None
 0.68A 6fn9A-2gw1A:
4.9		 6fn9A-2gw1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 MET A 551
GLN A 554
ARG A 209
 None
 0.63A 6fnaB-2gw1A:
4.9		 6fnaB-2gw1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 MET A 551
GLN A 554
ARG A 209
 None
 0.69A 6fnbA-2gw1A:
4.8		 6fnbA-2gw1A:
20.27