SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 ASP A 237
PHE A 204
ARG A 241
 None
 0.90A 2a3aA-2gwcA:
undetectable		 2a3aA-2gwcA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 PRO A 160
THR A 215
PRO A 217
 BSC  A   2 (-4.4A)
None
None
 0.76A 2d55C-2gwcA:
undetectable		 2d55C-2gwcA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 8 LEU A 350
PHE A 349
PHE A 346
LEU A  86
 None
 0.95A 2eilP-2gwcA:
undetectable
2eilW-2gwcA:
undetectable		 2eilP-2gwcA:
19.51
2eilW-2gwcA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 6 PRO A 328
MET A 329
ASP A 340
TYR A 227
 None
 1.38A 2lh8A-2gwcA:
undetectable		 2lh8A-2gwcA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 5 LEU A 400
LEU A 407
MET A 384
THR A 177
 None
 1.41A 2oaxD-2gwcA:
undetectable		 2oaxD-2gwcA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 ARG A 387
ASN A 277
THR A 242
 BSC  A   2 (-2.6A)
None
BSC  A   2 (-3.7A)
 0.88A 2q63A-2gwcA:
undetectable		 2q63A-2gwcA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 6 LEU A 350
PHE A 349
PHE A 346
LEU A  86
 None
 0.94A 3abkP-2gwcA:
undetectable
3abkW-2gwcA:
undetectable		 3abkP-2gwcA:
19.51
3abkW-2gwcA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 8 LEU A 350
PHE A 349
PHE A 346
LEU A  86
 None
 0.91A 3asoC-2gwcA:
undetectable
3asoJ-2gwcA:
undetectable		 3asoC-2gwcA:
19.51
3asoJ-2gwcA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 8 PHE A 275
GLY A 391
LEU A 512
PRO A 393
 None
 1.02A 3bgdB-2gwcA:
undetectable		 3bgdB-2gwcA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 12 THR A 242
ASN A 277
ASP A 390
ILE A 213
GLY A 161
 BSC  A   2 (-3.7A)
None
None
None
None
 1.17A 3eeyA-2gwcA:
undetectable		 3eeyA-2gwcA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 12 THR A 242
ASN A 277
ASP A 390
ILE A 213
GLY A 161
 BSC  A   2 (-3.7A)
None
None
None
None
 1.16A 3eeyF-2gwcA:
undetectable		 3eeyF-2gwcA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 12 THR A 242
ASN A 277
ASP A 390
ILE A 213
GLY A 161
 BSC  A   2 (-3.7A)
None
None
None
None
 1.17A 3eeyH-2gwcA:
undetectable		 3eeyH-2gwcA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 12 THR A 242
ASN A 277
ASP A 390
ILE A 213
GLY A 161
 BSC  A   2 (-3.7A)
None
None
None
None
 1.17A 3eeyI-2gwcA:
undetectable		 3eeyI-2gwcA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 MET A 119
MET A 202
PHE A 164
 None
 1.27A 3gn8A-2gwcA:
undetectable		 3gn8A-2gwcA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 7 PHE A 275
VAL A 479
VAL A 483
LEU A 441
VAL A 453
 None
 1.40A 3hs6B-2gwcA:
undetectable		 3hs6B-2gwcA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 9 GLY A 388
ALA A 389
ASP A 390
ILE A 270
LEU A 400
 None
 0.90A 3ogpA-2gwcA:
undetectable		 3ogpA-2gwcA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 9 GLY A 388
ALA A 389
ASP A 390
ILE A 270
LEU A 400
 None
 0.88A 3ogpB-2gwcA:
undetectable		 3ogpB-2gwcA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 12 GLY A 388
ALA A 389
ASP A 390
ILE A 270
LEU A 400
 None
 0.85A 3ogqB-2gwcA:
undetectable		 3ogqB-2gwcA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 9 LEU A 418
VAL A 479
ILE A 270
LEU A 408
VAL A 405
 None
 1.42A 3oxzA-2gwcA:
undetectable		 3oxzA-2gwcA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 8 GLY A 388
ALA A 389
ASP A 390
ILE A 270
 None
 0.64A 3so9A-2gwcA:
undetectable		 3so9A-2gwcA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 7 GLY A 388
ALA A 389
ASP A 390
ILE A 270
 None
 0.50A 3t3cA-2gwcA:
undetectable		 3t3cA-2gwcA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 6 MET A 384
LEU A 380
GLN A 319
TYR A 320
 None
 1.48A 3vkxA-2gwcA:
undetectable		 3vkxA-2gwcA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 6 LEU A 350
PHE A 349
PHE A 346
LEU A  86
 None
 0.97A 3wg7P-2gwcA:
undetectable
3wg7W-2gwcA:
undetectable		 3wg7P-2gwcA:
19.51
3wg7W-2gwcA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 8 GLU A 180
HIS A 106
GLU A 107
GLN A 246
 None
None
BSC  A   2 ( 3.0A)
None
 0.94A 4f93B-2gwcA:
undetectable		 4f93B-2gwcA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 8 HIS A 106
GLU A 165
GLY A 168
SER A 167
 None
MG  A   1 (-2.7A)
None
None
 0.88A 4f93B-2gwcA:
undetectable		 4f93B-2gwcA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLW_A_TESA1001_1
(ANDROGEN RECEPTOR)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 12 LEU A 407
GLY A 264
GLN A 268
MET A 386
VAL A 247
 None
 1.18A 4hlwA-2gwcA:
undetectable		 4hlwA-2gwcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 7 TYR A 383
GLU A 385
PRO A 376
PHE A 251
 None
 1.02A 5aclA-2gwcA:
undetectable		 5aclA-2gwcA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		5 / 12 LEU A 265
PHE A 261
GLU A 385
ARG A 387
TRP A 296
 None
None
None
BSC  A   2 (-2.6A)
BSC  A   2 (-4.0A)
 1.19A 5f9zB-2gwcA:
undetectable		 5f9zB-2gwcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 ILE A 213
MET A 224
ASP A 237
 None
BSC  A   2 ( 4.2A)
None
 0.76A 5h2uA-2gwcA:
undetectable		 5h2uA-2gwcA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 LYS A 301
LEU A 307
ILE A 374
 None
 0.77A 5kc4A-2gwcA:
undetectable		 5kc4A-2gwcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 VAL A 483
ARG A 429
PRO A 269
 None
 0.76A 5koxA-2gwcA:
1.4		 5koxA-2gwcA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 7 GLY A 388
ALA A 389
ASP A 390
ILE A 270
 None
 0.48A 5kqyB-2gwcA:
undetectable		 5kqyB-2gwcA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 8 GLY A 388
ALA A 389
ASP A 390
ILE A 270
 None
 0.53A 5kr1B-2gwcA:
undetectable		 5kr1B-2gwcA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 ARG A 292
PHE A 199
LEU A 397
 BSC  A   2 (-3.9A)
None
None
 0.83A 5veuA-2gwcA:
undetectable		 5veuA-2gwcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 5 LEU A 350
PHE A 349
PHE A 346
LEU A  86
 None
 0.96A 5x1bP-2gwcA:
undetectable		 5x1bP-2gwcA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 4 VAL A 405
LEU A 408
LEU A 414
ASP A 256
 None
 1.43A 5xv7A-2gwcA:
0.4		 5xv7A-2gwcA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		4 / 6 LEU A 476
LEU A 274
ARG A 433
ARG A 387
 None
None
None
BSC  A   2 (-2.6A)
 1.09A 6ew0G-2gwcA:
undetectable		 6ew0G-2gwcA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 ARG A 387
LYS A 381
TYR A 320
 BSC  A   2 (-2.6A)
None
None
 1.24A 6gnaA-2gwcA:
undetectable		 6gnaA-2gwcA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2gwc GLUTAMATE CYSTEINE
LIGASE
(Brassica
juncea) 		3 / 3 ARG A 387
LYS A 381
TYR A 320
 BSC  A   2 (-2.6A)
None
None
 1.24A 6gnbA-2gwcA:
undetectable		 6gnbA-2gwcA:
19.56