SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2gwf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Homo
sapiens) 		3 / 3 TRP A 284
ALA A 232
VAL A 230
 None
 0.99A 1bdwA-2gwfA:
undetectable
1bdwB-2gwfA:
undetectable		 1bdwA-2gwfA:
9.09
1bdwB-2gwfA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		5 / 9 VAL B 287
LEU B 233
ILE B 199
SER B 205
LEU B 206
 None
 0.85A 1eqgA-2gwfB:
undetectable		 1eqgA-2gwfB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		5 / 11 VAL B 287
LEU B 233
ILE B 199
SER B 205
LEU B 206
 None
 0.86A 1eqgB-2gwfB:
undetectable		 1eqgB-2gwfB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2gwf RING FINGER PROTEIN
41
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Homo
sapiens) 		4 / 8 PHE B 310
ASP A 241
LEU B 259
LEU B 306
 None
 0.92A 2bfpC-2gwfB:
undetectable		 2bfpC-2gwfB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2gwf RING FINGER PROTEIN
41
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Homo
sapiens) 		4 / 8 PHE B 310
ASP A 241
LEU B 259
LEU B 306
 None
 0.94A 2bfpD-2gwfB:
undetectable		 2bfpD-2gwfB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 2gwf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Homo
sapiens) 		5 / 11 LEU A 297
ILE A 183
MET A 192
LEU A 239
VAL A 221
 None
 1.41A 2n27A-2gwfA:
undetectable		 2n27A-2gwfA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		5 / 9 ILE B 242
ALA B 290
LEU B 246
ASN B 249
VAL B 301
 None
 1.39A 3o01A-2gwfB:
0.0
3o01B-2gwfB:
0.0		 3o01A-2gwfB:
21.77
3o01B-2gwfB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		3 / 3 MET B 267
GLN B 266
ARG B 265
 None
 0.89A 5ewzB-2gwfB:
undetectable		 5ewzB-2gwfB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		3 / 3 MET B 267
GLN B 266
ARG B 265
 None
 0.91A 5m35B-2gwfB:
undetectable		 5m35B-2gwfB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		3 / 3 MET B 267
GLN B 266
ARG B 265
 None
 0.95A 5m36A-2gwfB:
undetectable		 5m36A-2gwfB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2gwf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Homo
sapiens) 		4 / 5 ASP A 203
GLY A 300
TRP A 304
CYH A 214
 None
 1.47A 5nn8A-2gwfA:
undetectable		 5nn8A-2gwfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		5 / 12 GLY B 237
ILE B 280
VAL B 243
LEU B 246
ILE B 247
 None
 0.92A 6ectA-2gwfB:
undetectable		 6ectA-2gwfB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		5 / 12 GLY B 237
ILE B 280
VAL B 243
LEU B 246
ILE B 247
 None
 0.89A 6ecxA-2gwfB:
undetectable		 6ecxA-2gwfB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		3 / 3 MET B 267
GLN B 266
ARG B 265
 None
 0.93A 6fn9A-2gwfB:
undetectable		 6fn9A-2gwfB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		3 / 3 MET B 267
GLN B 266
ARG B 265
 None
 0.92A 6fnaB-2gwfB:
undetectable		 6fnaB-2gwfB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2gwf RING FINGER PROTEIN
41
(Homo
sapiens) 		3 / 3 MET B 267
GLN B 266
ARG B 265
 None
 0.93A 6fnbA-2gwfB:
undetectable		 6fnbA-2gwfB:
21.55