SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		4 / 7 ALA A 423
TYR A 418
SER A 448
ALA A 446
 None
 0.87A 1k5qA-2gwmA:
undetectable
1k5qB-2gwmA:
undetectable		 1k5qA-2gwmA:
24.89
1k5qB-2gwmA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 10 LEU A 427
VAL A 408
TYR A 412
GLY A 405
TYR A 432
 None
 1.49A 1lw0A-2gwmA:
undetectable		 1lw0A-2gwmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A 427
VAL A 408
TYR A 412
GLY A 405
TYR A 432
 None
 1.50A 1lwcA-2gwmA:
undetectable		 1lwcA-2gwmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 9 LEU A 427
VAL A 408
TYR A 412
GLY A 405
TYR A 432
 None
 1.49A 1vrtA-2gwmA:
undetectable		 1vrtA-2gwmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		4 / 6 PHE A 541
PRO A 542
THR A 545
ASN A 544
 None
 0.97A 5x24A-2gwmA:
undetectable		 5x24A-2gwmA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 9 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 1.06A 6ebpA-2gwmA:
undetectable		 6ebpA-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 10 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 1.05A 6ebpB-2gwmA:
undetectable		 6ebpB-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 10 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 1.02A 6ebpC-2gwmA:
undetectable		 6ebpC-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 1.02A 6ebzA-2gwmA:
undetectable		 6ebzA-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 1.00A 6ebzB-2gwmA:
undetectable		 6ebzB-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 1.05A 6ebzC-2gwmA:
undetectable		 6ebzC-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 0.97A 6ebzD-2gwmA:
undetectable		 6ebzD-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 0.89A 6gp2A-2gwmA:
undetectable		 6gp2A-2gwmA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2gwm 65 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 0.93A 6gp2B-2gwmA:
undetectable		 6gp2B-2gwmA:
15.42