SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 6 LYS A 322
GLY A 332
ASN A 281
PRO A 316
 None
 1.15A 1dedA-2gwnA:
3.3		 1dedA-2gwnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		3 / 3 VAL A  85
ALA A  86
HIS A 338
 None
None
CL  A 605 (-4.2A)
 0.76A 1q23C-2gwnA:
undetectable		 1q23C-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 4 ALA A  83
VAL A  85
ALA A  86
HIS A 338
 None
None
None
CL  A 605 (-4.2A)
 0.98A 1q23A-2gwnA:
undetectable		 1q23A-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		3 / 3 VAL A  85
ALA A  86
HIS A 338
 None
None
CL  A 605 (-4.2A)
 0.71A 1q23H-2gwnA:
undetectable		 1q23H-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		3 / 3 VAL A  85
ALA A  86
HIS A 338
 None
None
CL  A 605 (-4.2A)
 0.60A 1q23G-2gwnA:
undetectable		 1q23G-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 4 ALA A  83
VAL A  85
ALA A  86
HIS A 338
 None
None
None
CL  A 605 (-4.2A)
 0.86A 1q23K-2gwnA:
undetectable		 1q23K-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		3 / 3 VAL A  85
ALA A  86
HIS A 338
 None
None
CL  A 605 (-4.2A)
 0.66A 1q23J-2gwnA:
undetectable		 1q23J-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 5 GLY A  58
ILE A  60
VAL A 424
SER A  91
 None
 1.20A 1rs7A-2gwnA:
undetectable		 1rs7A-2gwnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 4 SER A 353
ILE A 357
VAL A 302
THR A 255
 None
 1.18A 1u70A-2gwnA:
undetectable		 1u70A-2gwnA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		3 / 3 LYS A 150
GLY A 147
PRO A 146
 KCX  A 149 ( 3.4A)
None
None
 1.02A 2hreB-2gwnA:
undetectable		 2hreB-2gwnA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 5 ASP A 389
SER A 391
LEU A   9
GLY A  52
 None
 1.23A 2j2pA-2gwnA:
undetectable
2j2pB-2gwnA:
undetectable		 2j2pA-2gwnA:
18.52
2j2pB-2gwnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 6 ALA A 398
ASP A 399
GLU A 411
ARG A 282
 None
 1.25A 2ouzA-2gwnA:
undetectable		 2ouzA-2gwnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 9 ILE A 260
ALA A 222
VAL A 225
GLU A 226
 None
SO4  A 609 ( 3.7A)
None
None
 0.83A 2vufA-2gwnA:
undetectable		 2vufA-2gwnA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 6 THR A 261
ILE A 309
LEU A 368
THR A 255
 None
 0.94A 3deuB-2gwnA:
undetectable		 3deuB-2gwnA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 6 HIS A 181
ASN A 286
ARG A 212
GLU A 185
 ZN  A 601 ( 3.2A)
CAC  A 603 ( 4.7A)
None
None
 1.39A 3galA-2gwnA:
undetectable		 3galA-2gwnA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 6 HIS A 181
ASN A 286
ARG A 212
GLU A 185
 ZN  A 601 ( 3.2A)
CAC  A 603 ( 4.7A)
None
None
 1.36A 3galB-2gwnA:
undetectable		 3galB-2gwnA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		3 / 3 ASP A 275
ARG A 278
ARG A 299
 None
None
GOL  A 614 (-3.5A)
 1.02A 3k37A-2gwnA:
undetectable		 3k37A-2gwnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 6 SER A 397
ARG A 434
GLY A 433
GLU A 437
 None
 1.12A 3k9fA-2gwnA:
undetectable
3k9fB-2gwnA:
undetectable
3k9fD-2gwnA:
undetectable		 3k9fA-2gwnA:
21.25
3k9fB-2gwnA:
21.25
3k9fD-2gwnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 5 ILE A 377
VAL A 358
HIS A 363
ASN A  12
 None
 1.27A 3nneA-2gwnA:
0.0		 3nneA-2gwnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 11 ALA A 121
ILE A  60
GLY A  58
VAL A 386
VAL A 336
 None
 1.25A 3oxxB-2gwnA:
undetectable		 3oxxB-2gwnA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 12 ILE A 371
PHE A 126
LEU A 177
PHE A 249
ILE A 307
 None
 1.08A 3pwwA-2gwnA:
undetectable		 3pwwA-2gwnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 12 CYH A 217
SER A 221
ALA A 224
ILE A 187
HIS A 239
 None
None
None
None
ZN  A 601 (-3.5A)
 1.28A 3qt0A-2gwnA:
0.0		 3qt0A-2gwnA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 8 PHE A 415
VAL A 396
ILE A 401
GLU A 345
 None
 1.10A 4a97D-2gwnA:
undetectable		 4a97D-2gwnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		3 / 3 TYR A 123
ARG A 374
HIS A 443
 None
None
SO4  A 607 (-3.9A)
 1.07A 4fubA-2gwnA:
undetectable		 4fubA-2gwnA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 4 LYS A 164
LEU A 167
GLU A 168
LEU A 227
 None
 1.44A 4k4yE-2gwnA:
undetectable		 4k4yE-2gwnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 12 VAL A 358
ALA A 362
PHE A  56
VAL A 386
GLY A  58
 None
 1.23A 4mm6A-2gwnA:
undetectable		 4mm6A-2gwnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 6 ILE A  28
PHE A  27
ILE A 371
LEU A 385
 None
 0.77A 4o8fB-2gwnA:
undetectable		 4o8fB-2gwnA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 8 ILE A  31
VAL A  21
VAL A  85
ILE A  60
ASP A 384
 None
 1.08A 5hi2A-2gwnA:
undetectable		 5hi2A-2gwnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 9 ILE A 237
VAL A 161
LEU A 167
ILE A 170
LEU A 248
 None
 1.33A 5iepA-2gwnA:
undetectable		 5iepA-2gwnA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A 177
GLY A 147
PRO A 146
VAL A 145
PHE A 369
 None
 1.39A 5jo9A-2gwnA:
undetectable		 5jo9A-2gwnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 12 GLU A 321
LYS A  74
GLY A 333
ALA A  83
VAL A  64
 None
 1.21A 5kbwB-2gwnA:
undetectable		 5kbwB-2gwnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 12 GLU A 263
LEU A 148
ALA A 179
THR A 102
ARG A 112
 None
KCX  A 149 ( 3.7A)
KCX  A 149 ( 4.4A)
None
None
 1.22A 5nd3B-2gwnA:
1.8		 5nd3B-2gwnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		5 / 8 ASP A 313
HIS A 239
HIS A 181
PRO A 287
HIS A  65
 ZN  A 602 (-2.5A)
ZN  A 601 (-3.5A)
ZN  A 601 ( 3.2A)
None
ZN  A 602 ( 3.4A)
 1.44A 5nekB-2gwnA:
2.9		 5nekB-2gwnA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		4 / 4 VAL A  21
LEU A   4
LEU A  42
ASP A  40
 None
 1.48A 5xv7A-2gwnA:
undetectable		 5xv7A-2gwnA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2gwn DIHYDROOROTASE
(Porphyromonas
gingivalis) 		3 / 3 TYR A 199
LEU A 210
ASP A 273
 None
 0.71A 5zv2B-2gwnA:
undetectable		 5zv2B-2gwnA:
12.79