SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT5_A_RTLA176_0 (PLASMA RETINOL-BINDING PROTEIN)	2gwo	DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 (Homo sapiens)	5 / 12	LEU A 148 ALA A 80 ALA A 78 LEU A 55 TYR A 122	None	1.39A	1kt5A-2gwoA: undetectable	1kt5A-2gwoA: 22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MB5_A_SAMA301_1 (SAM-DEPENDENT METHYLTRANSFERASE)	2gwo	DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 (Homo sapiens)	4 / 4	GLY A 81 GLU A 103 ASP A 105 ASP A 86	None	1.42A	3mb5A-2gwoA: undetectable	3mb5A-2gwoA: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K39_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	2gwo	DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 (Homo sapiens)	5 / 12	ASN A 44 LEU A 55 VAL A 142 ILE A 174 LEU A 35	None	1.22A	4k39A-2gwoA: undetectable	4k39A-2gwoA: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BMV_C_VLBC507_2 (TUBULIN ALPHA-1B CHAIN)	2gwo	DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 (Homo sapiens)	4 / 7	VAL A 119 ILE A 123 VAL A 76 ILE A 102	None	0.72A	5bmvC-2gwoA: undetectable	5bmvC-2gwoA: 19.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KT5_A_RTLA176_0","PLASMA RETINOL-BINDING PROTEIN","2gwo","DUAL SPECIFICITY PROTEIN PHOSPHATASE 13","Homo sapiens",5,"LEU A 148;ALA A  80;ALA A  78;LEU A  55;TYR A 122","None","1.39A","1kt5A-2gwoA:undetectable","1kt5A-2gwoA:22.79"],["3MB5_A_SAMA301_1","SAM-DEPENDENT METHYLTRANSFERASE","2gwo","DUAL SPECIFICITY PROTEIN PHOSPHATASE 13","Homo sapiens",4,"GLY A  81;GLU A 103;ASP A 105;ASP A  86","None","1.42A","3mb5A-2gwoA:undetectable","3mb5A-2gwoA:21.01"],["4K39_A_SAMA504_0","ANAEROBIC SULFATASE-MATURATING ENZYME","2gwo","DUAL SPECIFICITY PROTEIN PHOSPHATASE 13","Homo sapiens",5,"ASN A  44;LEU A  55;VAL A 142;ILE A 174;LEU A  35","None","1.22A","4k39A-2gwoA:undetectable","4k39A-2gwoA:18.70"],["5BMV_C_VLBC507_2","TUBULIN ALPHA-1B CHAIN","2gwo","DUAL SPECIFICITY PROTEIN PHOSPHATASE 13","Homo sapiens",4,"VAL A 119;ILE A 123;VAL A  76;ILE A 102","None","0.72A","5bmvC-2gwoA:undetectable","5bmvC-2gwoA:19.62"]]