SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 167
LEU A 131
ILE A 152
VAL A 140
ILE A 138
 GOL  A2648 (-4.0A)
None
None
None
None
 1.08A 2avoA-2gwrA:
undetectable		 2avoA-2gwrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		6 / 10 ALA A  41
ALA A  44
LEU A  48
LEU A   9
ALA A  33
LEU A  55
 None
 1.33A 2bxgB-2gwrA:
undetectable		 2bxgB-2gwrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  65
GLY A  64
ILE A  79
VAL A  11
GLY A  94
 None
 0.93A 3bwcA-2gwrA:
undetectable		 3bwcA-2gwrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  65
GLY A  64
ILE A  79
VAL A  11
GLY A  94
 None
 1.00A 3bwcB-2gwrA:
3.0		 3bwcB-2gwrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  98
ILE A  65
ASN A  63
MET A  62
THR A 155
 None
 1.17A 3ckkA-2gwrA:
3.1		 3ckkA-2gwrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  54
ASP A  13
VAL A  34
THR A  22
 None
CA  A2644 (-3.2A)
None
None
 1.17A 3cyxB-2gwrA:
undetectable		 3cyxB-2gwrA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 185
ASP A 101
TRP A 183
HIS A 197
 None
 1.38A 3zodA-2gwrA:
undetectable		 3zodA-2gwrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		5 / 8 LEU A  71
VAL A  67
ILE A  35
ALA A  44
LEU A   9
 None
 1.27A 4qrcA-2gwrA:
undetectable		 4qrcA-2gwrA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 168
PRO A 169
LYS A 224
 None
 1.27A 5y9yA-2gwrA:
undetectable		 5y9yA-2gwrA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 112
LEU A  17
THR A  83
PRO A  60
 None
 1.04A 6ew0F-2gwrA:
undetectable		 6ew0F-2gwrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2gwr DNA-BINDING RESPONSE
REGULATOR MTRA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 112
LEU A  17
THR A  83
PRO A  60
 None
 1.04A 6ew0G-2gwrA:
undetectable		 6ew0G-2gwrA:
17.18