SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 ASP A 107
HIS A  68
HIS A  69
HIS A 103
 ZN  A 375 (-2.3A)
ZN  A 375 (-3.3A)
ZN  A 374 (-3.4A)
ZN  A 375 (-4.8A)
 0.99A 1ei6D-2gx8A:
undetectable		 1ei6D-2gx8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 11 ILE A 208
ALA A 161
VAL A 216
MET A 220
VAL A 142
 None
 1.26A 1n4hA-2gx8A:
undetectable		 1n4hA-2gx8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 4 HIS A  68
GLU A 336
HIS A  69
HIS A 103
 ZN  A 375 (-3.3A)
ZN  A 375 ( 2.5A)
ZN  A 374 (-3.4A)
ZN  A 375 (-4.8A)
 1.27A 1uttA-2gx8A:
undetectable		 1uttA-2gx8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 4 HIS A  68
GLU A 336
HIS A  69
HIS A 103
 ZN  A 375 (-3.3A)
ZN  A 375 ( 2.5A)
ZN  A 374 (-3.4A)
ZN  A 375 (-4.8A)
 1.25A 2ozrE-2gx8A:
undetectable		 2ozrE-2gx8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 TYR A 100
TYR A  18
GLN A 344
ILE A  45
 None
 1.20A 2pgzD-2gx8A:
undetectable
2pgzE-2gx8A:
undetectable		 2pgzD-2gx8A:
16.62
2pgzE-2gx8A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 VAL A 142
VAL A 216
HIS A 224
VAL A 144
 None
 1.02A 3fhxB-2gx8A:
undetectable		 3fhxB-2gx8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		3 / 3 HIS A  69
HIS A  68
HIS A 103
 ZN  A 374 (-3.4A)
ZN  A 375 (-3.3A)
ZN  A 375 (-4.8A)
 0.65A 3mihA-2gx8A:
undetectable		 3mihA-2gx8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		3 / 3 HIS A 103
HIS A  69
HIS A  68
 ZN  A 375 (-4.8A)
ZN  A 374 (-3.4A)
ZN  A 375 (-3.3A)
 0.64A 3mihA-2gx8A:
undetectable		 3mihA-2gx8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 9 ILE A  88
ILE A  89
VAL A  49
ILE A  33
ILE A  99
 None
 1.15A 3p4wB-2gx8A:
undetectable		 3p4wB-2gx8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A  88
ILE A  89
VAL A  49
ILE A  33
ILE A  99
 None
 1.14A 3p4wD-2gx8A:
undetectable		 3p4wD-2gx8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A  88
ILE A  89
VAL A  49
ILE A  33
ILE A  99
 None
 1.15A 3p4wE-2gx8A:
undetectable		 3p4wE-2gx8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 10 LEU A  71
LEU A  31
ILE A  99
ALA A  98
VAL A  43
 None
 1.43A 3r9cA-2gx8A:
undetectable		 3r9cA-2gx8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 GLU A 241
GLY A 240
LEU A 243
TYR A 133
 None
 1.15A 3w9tB-2gx8A:
undetectable		 3w9tB-2gx8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 GLU A 241
GLY A 240
LEU A 243
TYR A 133
 None
 1.15A 3w9tE-2gx8A:
undetectable		 3w9tE-2gx8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 GLU A 241
GLY A 240
LEU A 243
TYR A 133
 None
 1.15A 3w9tF-2gx8A:
undetectable		 3w9tF-2gx8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 10 ALA A  57
ILE A  97
ILE A  33
LEU A  71
ILE A  99
 None
 1.24A 4dtaA-2gx8A:
undetectable		 4dtaA-2gx8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 10 TYR A 100
VAL A  64
VAL A  40
GLU A  15
LEU A 347
 None
 1.22A 4jq4A-2gx8A:
undetectable		 4jq4A-2gx8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 ASP A 107
ALA A 109
TYR A  18
ASP A  27
 ZN  A 375 (-2.3A)
None
None
None
 1.18A 4mdaA-2gx8A:
undetectable		 4mdaA-2gx8A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 ASP A 107
ALA A 109
TYR A  18
ASP A  27
 ZN  A 375 (-2.3A)
None
None
None
 1.10A 4mdbA-2gx8A:
undetectable		 4mdbA-2gx8A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		3 / 3 PRO A  39
VAL A 358
HIS A 359
 None
 0.80A 4pevC-2gx8A:
undetectable		 4pevC-2gx8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A  10
GLY A   7
ASN A  37
ALA A  35
VAL A  40
 None
 1.14A 4rvgA-2gx8A:
undetectable		 4rvgA-2gx8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		3 / 3 VAL A 113
LEU A 117
VAL A 338
 None
 0.58A 4wq4A-2gx8A:
undetectable		 4wq4A-2gx8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2gx8 NIF3-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A  99
THR A  81
GLU A  90
ALA A  35
ILE A  58
 None
 1.39A 5iwuA-2gx8A:
undetectable		 5iwuA-2gx8A:
21.81