SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2gxf HYPOTHETICAL PROTEIN
YYBH
(Bacillus
subtilis) 		3 / 3 THR A 103
ASP A 125
GLU A  99
 None
 0.79A 3qowA-2gxfA:
undetectable		 3qowA-2gxfA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gxf HYPOTHETICAL PROTEIN
YYBH
(Bacillus
subtilis) 		4 / 8 VAL A  35
TYR A 104
CYH A 116
ILE A 118
 None
MES  A 201 (-3.3A)
MES  A 201 ( 4.0A)
None
 1.22A 4bqtC-2gxfA:
undetectable
4bqtD-2gxfA:
undetectable		 4bqtC-2gxfA:
19.91
4bqtD-2gxfA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2gxf HYPOTHETICAL PROTEIN
YYBH
(Bacillus
subtilis) 		4 / 7 TYR A 104
ILE A   9
LEU A  72
PHE A 106
 MES  A 201 (-3.3A)
MES  A 201 (-4.2A)
None
MES  A 201 (-4.7A)
 0.85A 4iqqA-2gxfA:
undetectable		 4iqqA-2gxfA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2gxf HYPOTHETICAL PROTEIN
YYBH
(Bacillus
subtilis) 		4 / 8 TYR A 104
ILE A   9
LEU A  72
PHE A 106
 MES  A 201 (-3.3A)
MES  A 201 (-4.2A)
None
MES  A 201 (-4.7A)
 0.87A 4iqqD-2gxfA:
undetectable		 4iqqD-2gxfA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2gxf HYPOTHETICAL PROTEIN
YYBH
(Bacillus
subtilis) 		3 / 3 THR A 103
ASP A 125
GLU A  99
 None
 0.84A 5fa8A-2gxfA:
undetectable		 5fa8A-2gxfA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2gxf HYPOTHETICAL PROTEIN
YYBH
(Bacillus
subtilis) 		4 / 7 TYR A 104
ILE A   9
LEU A  72
PHE A 106
 MES  A 201 (-3.3A)
MES  A 201 (-4.2A)
None
MES  A 201 (-4.7A)
 0.83A 5nooA-2gxfA:
undetectable		 5nooA-2gxfA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2gxf HYPOTHETICAL PROTEIN
YYBH
(Bacillus
subtilis) 		4 / 8 TYR A 104
ILE A   9
LEU A  72
PHE A 106
 MES  A 201 (-3.3A)
MES  A 201 (-4.2A)
None
MES  A 201 (-4.7A)
 0.81A 5nooD-2gxfA:
undetectable		 5nooD-2gxfA:
17.83