SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 7 MET A 116
GLN A  67
ALA A  63
PHE A 203
 None
 1.21A 1t9wA-2gy5A:
undetectable		 1t9wA-2gy5A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		5 / 10 VAL A 278
LEU A 129
THR A 130
THR A 128
PRO A 126
 None
 1.26A 3cajA-2gy5A:
undetectable		 3cajA-2gy5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		5 / 10 VAL A 278
LEU A 129
THR A 130
THR A 128
PRO A 126
 None
 1.28A 3dcwA-2gy5A:
undetectable		 3dcwA-2gy5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		5 / 10 VAL A 278
LEU A 129
THR A 130
THR A 128
PRO A 126
 None
 1.27A 3dd0A-2gy5A:
undetectable		 3dd0A-2gy5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 188
SER A 190
LEU A  64
 None
 0.73A 3n8xA-2gy5A:
3.1		 3n8xA-2gy5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		3 / 3 HIS A 177
SER A 142
GLU A 175
 NAG  A1140 ( 4.8A)
None
NAG  A1140 ( 4.6A)
 0.80A 3s8pA-2gy5A:
undetectable		 3s8pA-2gy5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		3 / 3 ARG A 249
GLU A 239
ASN A 427
 None
 0.89A 4ip7D-2gy5A:
undetectable		 4ip7D-2gy5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 429
GLY A 431
LYS A 253
 None
None
SO4  A   5 ( 4.0A)
 0.68A 4k50A-2gy5A:
undetectable		 4k50A-2gy5A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 429
GLY A 431
LYS A 253
 None
None
SO4  A   5 ( 4.0A)
 0.64A 4k50E-2gy5A:
undetectable		 4k50E-2gy5A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 429
GLY A 431
LYS A 253
 None
None
SO4  A   5 ( 4.0A)
 0.70A 4k50I-2gy5A:
undetectable		 4k50I-2gy5A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 296
LEU A  42
ASN A  97
 None
 0.65A 4otwA-2gy5A:
undetectable		 4otwA-2gy5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 7 TRP A 216
GLU A 239
GLU A 381
GLU A 382
 None
 1.31A 4r87J-2gy5A:
undetectable
4r87L-2gy5A:
undetectable		 4r87J-2gy5A:
16.30
4r87L-2gy5A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 8 ILE A  55
ILE A 113
ILE A 111
GLU A 103
 None
 0.66A 5mvmA-2gy5A:
undetectable
5mvmB-2gy5A:
undetectable		 5mvmA-2gy5A:
12.10
5mvmB-2gy5A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 7 GLU A 382
ARG A 347
THR A 349
PRO A 350
 None
None
SO4  A   5 (-3.5A)
None
 1.32A 6a4iB-2gy5A:
undetectable		 6a4iB-2gy5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2gy5 ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 6 GLY A 328
GLY A 308
PRO A 309
GLY A 292
 None
 0.74A 6ag0C-2gy5A:
undetectable		 6ag0C-2gy5A:
10.07