SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gy7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 6 TRP A 354
TRP A 446
ASN A 456
PRO A 452
 None
 1.12A 1dedA-2gy7A:
undetectable		 1dedA-2gy7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		3 / 3 ASP A 314
ILE A 373
VAL A 360
 None
 0.63A 2avvD-2gy7A:
undetectable		 2avvD-2gy7A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 7 PHE A 335
GLY A 457
GLY A 331
PHE A 423
 None
 0.79A 3ko0M-2gy7A:
undetectable
3ko0P-2gy7A:
undetectable		 3ko0M-2gy7A:
17.62
3ko0P-2gy7A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 6 THR A 364
GLN A 367
TYR A 369
ILE A 491
 None
 1.19A 3peoG-2gy7A:
undetectable		 3peoG-2gy7A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		5 / 9 ILE A 309
LEU A 355
ILE A 325
ILE A 324
ILE A 491
 None
 1.07A 3zosA-2gy7A:
undetectable		 3zosA-2gy7A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		5 / 12 GLY A 331
GLU A 352
ASN A 470
SER A 483
ILE A 472
 None
 1.29A 4pb1A-2gy7A:
undetectable		 4pb1A-2gy7A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 7 SER A 361
GLU A 358
TRP A 446
ASP A 422
 None
 1.21A 4uacA-2gy7A:
undetectable		 4uacA-2gy7A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 7 ILE A 472
LEU A 484
ILE A 324
ALA A 383
 None
 0.81A 6b5vA-2gy7A:
undetectable
6b5vC-2gy7A:
undetectable		 6b5vA-2gy7A:
15.28
6b5vC-2gy7A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 7 ALA A 383
ILE A 472
LEU A 484
ILE A 324
 None
 0.82A 6b5vA-2gy7A:
undetectable
6b5vB-2gy7A:
undetectable		 6b5vA-2gy7A:
15.28
6b5vB-2gy7A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 7 ILE A 472
LEU A 484
ILE A 324
ALA A 383
 None
 0.82A 6b5vC-2gy7A:
undetectable
6b5vD-2gy7A:
undetectable		 6b5vC-2gy7A:
15.28
6b5vD-2gy7A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 7 ALA A 383
ILE A 472
LEU A 484
ILE A 324
 None
 0.81A 6b5vB-2gy7A:
undetectable
6b5vD-2gy7A:
undetectable		 6b5vB-2gy7A:
15.28
6b5vD-2gy7A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 7 SER A 415
SER A 385
GLY A 408
LEU A 375
 None
 1.07A 6btxA-2gy7A:
undetectable		 6btxA-2gy7A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		5 / 12 ILE A 309
TRP A 354
SER A 350
PHE A 346
LEU A 300
 None
 1.49A 6chgC-2gy7A:
undetectable		 6chgC-2gy7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 2gy7 ANGIOPOIETIN-2
(Homo
sapiens) 		4 / 8 TRP A 339
GLY A 443
GLN A 336
PHE A 346
 None
 0.91A 6eqpA-2gy7A:
undetectable		 6eqpA-2gy7A:
17.24