SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN
(Rhodopseudomonas
palustris) 		4 / 5 ILE A  29
LEU A  49
ALA A 110
GLU A 114
 None
None
None
ZN  A 409 ( 2.3A)
 0.93A 1xvaA-2gyqA:
undetectable
1xvaB-2gyqA:
undetectable		 1xvaA-2gyqA:
23.13
1xvaB-2gyqA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 ALA A 110
GLU A 114
ILE A  29
LEU A  49
 None
ZN  A 409 ( 2.3A)
None
None
 0.83A 1xvaA-2gyqA:
undetectable
1xvaB-2gyqA:
undetectable		 1xvaA-2gyqA:
23.13
1xvaB-2gyqA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN
(Rhodopseudomonas
palustris) 		4 / 8 GLY A  76
ILE A  22
PHE A 139
PHE A  67
 None
 0.89A 3ko0K-2gyqA:
1.4
3ko0S-2gyqA:
1.4		 3ko0K-2gyqA:
19.25
3ko0S-2gyqA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN
(Rhodopseudomonas
palustris) 		4 / 7 MET A  36
LEU A  85
ALA A  89
THR A  92
 None
None
None
ZN  A 410 ( 4.6A)
 0.94A 4ik7A-2gyqA:
undetectable		 4ik7A-2gyqA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN
(Rhodopseudomonas
palustris) 		3 / 3 LYS A  73
PRO A  74
SER A  75
 None
 0.43A 4k50I-2gyqA:
undetectable		 4k50I-2gyqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN
(Rhodopseudomonas
palustris) 		4 / 8 LEU A 131
VAL A 137
LEU A 140
GLY A  18
 None
 0.87A 4r3aA-2gyqA:
1.3		 4r3aA-2gyqA:
20.79