SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 8 ILE A 123
LEU A 116
GLU A 339
ALA A 338
VAL A  92
 None
 1.49A 1a29A-2gz3A:
undetectable		 1a29A-2gz3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 10 ALA A 202
GLU A 167
ARG A 170
GLU A 174
LEU A 185
 None
 1.26A 1cmcA-2gz3A:
undetectable
1cmcB-2gz3A:
undetectable		 1cmcA-2gz3A:
14.66
1cmcB-2gz3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 6 HIS A 318
ILE A 317
ALA A 136
VAL A 269
 None
 1.01A 1hk1A-2gz3A:
undetectable		 1hk1A-2gz3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 8 VAL A 335
VAL A  65
VAL A   5
ILE A  19
LEU A  69
 None
 1.38A 1igxA-2gz3A:
undetectable		 1igxA-2gz3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 8 GLY A 316
ARG A 148
ILE A 150
ASP A 147
 None
 0.73A 1jg4A-2gz3A:
undetectable		 1jg4A-2gz3A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 202
GLU A 167
ARG A 170
GLU A 174
LEU A 185
 None
 1.20A 1mj2A-2gz3A:
undetectable
1mj2B-2gz3A:
undetectable		 1mj2A-2gz3A:
14.66
1mj2B-2gz3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 202
GLU A 167
ARG A 170
GLU A 174
LEU A 185
 None
 1.24A 1mj2C-2gz3A:
undetectable
1mj2D-2gz3A:
undetectable		 1mj2C-2gz3A:
14.66
1mj2D-2gz3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 202
GLU A 167
ARG A 170
GLU A 174
LEU A 185
 None
 1.23A 1mjoC-2gz3A:
undetectable
1mjoD-2gz3A:
undetectable		 1mjoC-2gz3A:
14.66
1mjoD-2gz3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 11 GLU A 167
ARG A 170
GLU A 174
LEU A 185
ALA A 202
 None
 1.30A 1mjqA-2gz3A:
undetectable
1mjqB-2gz3A:
undetectable		 1mjqA-2gz3A:
14.66
1mjqB-2gz3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		3 / 3 THR A 168
LEU A 172
VAL A 175
 None
 0.68A 1mz9E-2gz3A:
undetectable		 1mz9E-2gz3A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A 327
ASP A 324
GLY A 159
ALA A 331
 None
None
NAP  A 367 ( 3.1A)
None
 0.90A 2aohA-2gz3A:
undetectable		 2aohA-2gz3A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 250
THR A 302
GLN A 132
 None
 0.81A 2fk8A-2gz3A:
undetectable		 2fk8A-2gz3A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 253
TYR A 154
HIS A 252
 None
None
AS2  A 400 (-4.0A)
 0.70A 2r2vD-2gz3A:
undetectable		 2r2vD-2gz3A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 341
LEU A 346
THR A 350
VAL A  85
 None
 0.97A 3d2tA-2gz3A:
undetectable		 3d2tA-2gz3A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A 159
GLY A 161
MET A 162
ASN A 325
 NAP  A 367 ( 3.1A)
NAP  A 367 (-3.5A)
None
NAP  A 367 (-4.0A)
 0.96A 3e9rA-2gz3A:
undetectable		 3e9rA-2gz3A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A 159
GLY A 161
MET A 162
ASN A 325
 NAP  A 367 ( 3.1A)
NAP  A 367 (-3.5A)
None
NAP  A 367 (-4.0A)
 0.96A 3e9rC-2gz3A:
undetectable		 3e9rC-2gz3A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A 112
ALA A 115
ALA A 113
ARG A 344
 None
 1.41A 3kp2B-2gz3A:
undetectable		 3kp2B-2gz3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 ALA A 136
VAL A 269
VAL A 140
LEU A 137
 None
 0.83A 3o14A-2gz3A:
0.9		 3o14A-2gz3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 9 ILE A 317
ILE A 258
MET A 319
VAL A 269
ILE A 273
 None
 1.10A 3p4wB-2gz3A:
undetectable		 3p4wB-2gz3A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 10 ILE A 317
ILE A 258
MET A 319
VAL A 269
ILE A 273
 None
 1.11A 3p4wD-2gz3A:
undetectable		 3p4wD-2gz3A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 6 THR A 153
GLN A 132
ILE A 246
SER A 129
 None
 1.11A 3peoG-2gz3A:
undetectable		 3peoG-2gz3A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A  34
VAL A   7
PHE A  47
ILE A  29
 None
 0.94A 3zjqA-2gz3A:
undetectable		 3zjqA-2gz3A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A  34
VAL A   7
PHE A  47
ILE A  29
 None
 0.97A 3zjqB-2gz3A:
undetectable		 3zjqB-2gz3A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 6 GLU A 282
ILE A 289
PHE A 303
VAL A 248
 None
 1.24A 4a97I-2gz3A:
undetectable		 4a97I-2gz3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 MET A 134
ILE A 237
VAL A 151
MET A 319
 None
 1.22A 4f4dA-2gz3A:
4.1		 4f4dA-2gz3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 8 MET A 134
ILE A 237
VAL A 151
MET A 319
 None
 1.21A 4f4dB-2gz3A:
2.5		 4f4dB-2gz3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  12
ALA A  16
ASN A 325
SER A 158
ILE A 165
 NAP  A 367 (-3.3A)
None
NAP  A 367 (-4.0A)
None
None
 1.17A 4pb1A-2gz3A:
undetectable		 4pb1A-2gz3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  12
ALA A  16
ASN A 325
SER A 158
ILE A 165
 NAP  A 367 (-3.3A)
None
NAP  A 367 (-4.0A)
None
None
 1.11A 4pd9A-2gz3A:
undetectable		 4pd9A-2gz3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 THR A  60
ALA A  61
THR A  58
TYR A  80
 None
 1.11A 5ecmA-2gz3A:
undetectable		 5ecmA-2gz3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A 149
VAL A 140
GLU A 110
ALA A 274
VAL A 269
LEU A 281
 None
 1.30A 5igtA-2gz3A:
undetectable		 5igtA-2gz3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 123
PHE A 355
HIS A 119
THR A 350
VAL A  85
 None
 1.31A 6djzB-2gz3A:
undetectable		 6djzB-2gz3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A  67
GLU A 343
HIS A 342
VAL A 347
 None
 1.01A 6j20A-2gz3A:
undetectable		 6j20A-2gz3A:
20.35