SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		4 / 8 ALA A 266
GLU A 265
LEU A 261
LEU A 318
 None
 0.93A 1ereE-2gzaA:
undetectable		 1ereE-2gzaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		4 / 8 ALA A 266
GLU A 265
LEU A 261
LEU A 318
 None
 0.93A 1ereF-2gzaA:
undetectable		 1ereF-2gzaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 10 ILE A 208
ALA A 242
SER A 275
ILE A 256
THR A 240
 None
 1.32A 1j3jA-2gzaA:
undetectable		 1j3jA-2gzaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 11 ILE A 208
ALA A 242
SER A 275
ILE A 256
THR A 240
 None
 1.25A 2blaA-2gzaA:
undetectable		 2blaA-2gzaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		4 / 6 HIS A 222
GLU A 111
PHE A 226
PRO A 212
 None
 1.29A 2qqtA-2gzaA:
undetectable		 2qqtA-2gzaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		6 / 12 LEU A  96
GLY A  74
LEU A 225
SER A 247
ILE A 119
ILE A 206
 None
 1.29A 3frqB-2gzaA:
undetectable		 3frqB-2gzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		4 / 6 HIS A 222
GLU A 111
PHE A 226
PRO A 212
 None
 1.28A 3gclA-2gzaA:
undetectable		 3gclA-2gzaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 10 ARG A 176
ILE A 256
ILE A 206
ARG A 255
VAL A 172
 None
 1.30A 3ohtA-2gzaA:
0.0
3ohtB-2gzaA:
0.0		 3ohtA-2gzaA:
22.82
3ohtB-2gzaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 10 ILE A 208
ALA A 242
SER A 275
ILE A 256
THR A 240
 None
 1.29A 3qgtA-2gzaA:
undetectable		 3qgtA-2gzaA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 9 ILE A 208
ALA A 242
SER A 275
ILE A 256
THR A 240
 None
 1.21A 3tq8A-2gzaA:
undetectable		 3tq8A-2gzaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 10 ILE A 208
ALA A 242
SER A 275
ILE A 256
THR A 240
 None
 1.19A 4g8zX-2gzaA:
undetectable		 4g8zX-2gzaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 11 ALA A 266
ARG A 246
LEU A 245
ALA A 242
LEU A 318
 None
 1.01A 4nqaA-2gzaA:
undetectable		 4nqaA-2gzaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 12 GLY A 187
GLY A 185
LEU A 191
VAL A 328
HIS A 327
 SO4  A1001 (-3.7A)
SO4  A1001 (-2.6A)
None
None
None
 0.92A 4qdjA-2gzaA:
undetectable		 4qdjA-2gzaA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 12 ILE A 199
LEU A 214
PHE A 269
ALA A 273
GLY A 276
 None
 1.06A 5uxdB-2gzaA:
undetectable		 5uxdB-2gzaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		4 / 5 VAL A 239
LEU A 225
CYH A 110
ASP A  87
 None
 1.37A 5vcvA-2gzaA:
undetectable		 5vcvA-2gzaA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11
(Brucella
suis) 		5 / 12 LEU A 257
VAL A 180
PHE A 269
SER A 280
THR A 292
 None
 1.35A 6b50A-2gzaA:
0.9		 6b50A-2gzaA:
20.38