SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		5 / 12 GLU A 171
ILE A  64
SER A 149
PHE A 150
ILE A 168
 None
 1.18A 1q8jA-2gzhA:
2.4		 1q8jA-2gzhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2gzh RAS-RELATED PROTEIN
RAB-11A
RAB11-FIP2 LONG
ISOFORM
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP B 482
GLU A 108
ARG A  82
 None
MG  A 951 (-4.5A)
None
 0.89A 1wopA-2gzhB:
undetectable		 1wopA-2gzhB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		5 / 12 THR A  43
GLY A  23
GLY A  21
GLY A  69
ASP A 127
 MG  A 950 ( 3.2A)
GTP  A 900 (-3.1A)
GTP  A 900 (-3.8A)
GTP  A 900 (-3.7A)
GTP  A 900 (-2.9A)
 1.06A 2b25A-2gzhA:
undetectable		 2b25A-2gzhA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		4 / 8 TYR A  91
GLU A 152
PHE A 150
VAL A 102
 None
 0.81A 2fl5E-2gzhA:
undetectable
2fl5F-2gzhA:
undetectable		 2fl5E-2gzhA:
23.85
2fl5F-2gzhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 GLY A  83
TRP A  65
VAL A  15
 None
 0.72A 3n62B-2gzhA:
undetectable		 3n62B-2gzhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 GLY A  83
TRP A  65
VAL A  15
 None
 0.71A 3n65B-2gzhA:
undetectable		 3n65B-2gzhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 GLY A  83
TRP A  65
VAL A  15
 None
 0.74A 3n66B-2gzhA:
undetectable		 3n66B-2gzhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		4 / 7 ARG A 132
SER A 126
ASP A 137
GLU A 144
 None
 0.98A 5btaA-2gzhA:
undetectable
5btaC-2gzhA:
undetectable
5btaD-2gzhA:
3.5		 5btaA-2gzhA:
17.21
5btaC-2gzhA:
17.21
5btaD-2gzhA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		4 / 7 SER A 126
ASP A 137
GLU A 144
ARG A 132
 None
 0.98A 5btfA-2gzhA:
undetectable
5btfB-2gzhA:
3.9
5btfC-2gzhA:
undetectable		 5btfA-2gzhA:
17.21
5btfB-2gzhA:
24.42
5btfC-2gzhA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		4 / 7 ARG A 132
SER A 126
ASP A 137
GLU A 144
 None
 0.97A 5btfA-2gzhA:
undetectable
5btfC-2gzhA:
undetectable
5btfD-2gzhA:
3.4		 5btfA-2gzhA:
17.21
5btfC-2gzhA:
17.21
5btfD-2gzhA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 GLY A  83
TRP A  65
VAL A  15
 None
 0.72A 5vuoB-2gzhA:
undetectable		 5vuoB-2gzhA:
20.59