SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gzo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AFS_A_TESA325_1 (3-ALPHA-HYDROXYSTERO ID DEHYDROGENASE)	2gzo	UPF0301 PROTEIN SO3346 (Shewanella oneidensis)	4 / 7	LEU A 103 HIS A 154 ASN A 6 TYR A 26	None	0.92A	1afsA-2gzoA: undetectable	1afsA-2gzoA: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AFS_B_TESB325_1 (3-ALPHA-HYDROXYSTERO ID DEHYDROGENASE)	2gzo	UPF0301 PROTEIN SO3346 (Shewanella oneidensis)	4 / 7	LEU A 103 HIS A 154 ASN A 6 TYR A 26	None	0.92A	1afsB-2gzoA: undetectable	1afsB-2gzoA: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y4L_B_SVRB301_2 (PHOSPHOLIPASE A2 HOMOLOG 2)	2gzo	UPF0301 PROTEIN SO3346 (Shewanella oneidensis)	5 / 11	LEU A 103 LEU A 157 VAL A 85 GLY A 83 TYR A 26	None	1.32A	1y4lB-2gzoA: undetectable	1y4lB-2gzoA: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZB8_A_IMNA800_1 (PROSTAGLANDIN REDUCTASE 2)	2gzo	UPF0301 PROTEIN SO3346 (Shewanella oneidensis)	5 / 9	THR A 23 PHE A 158 LEU A 73 VAL A 126 LEU A 125	None	1.47A	2zb8A-2gzoA: 0.0	2zb8A-2gzoA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESH_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2gzo	UPF0301 PROTEIN SO3346 (Shewanella oneidensis)	5 / 12	ALA A 35 LEU A 27 GLY A 45 LEU A 128 PHE A 84	None	1.14A	5eshA-2gzoA: undetectable	5eshA-2gzoA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_A_P06A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2gzo	UPF0301 PROTEIN SO3346 (Shewanella oneidensis)	6 / 12	GLY A 76 LEU A 157 LEU A 27 ILE A 40 TRP A 147 GLY A 37	None	1.26A	5hieA-2gzoA: undetectable	5hieA-2gzoA: 21.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AFS_A_TESA325_1","3-ALPHA-HYDROXYSTEROID DEHYDROGENASE","2gzo","UPF0301 PROTEIN SO3346","Shewanella oneidensis",4,"LEU A 103;HIS A 154;ASN A   6;TYR A  26","None","0.92A","1afsA-2gzoA:undetectable","1afsA-2gzoA:19.70"],["1AFS_B_TESB325_1","3-ALPHA-HYDROXYSTEROID DEHYDROGENASE","2gzo","UPF0301 PROTEIN SO3346","Shewanella oneidensis",4,"LEU A 103;HIS A 154;ASN A   6;TYR A  26","None","0.92A","1afsB-2gzoA:undetectable","1afsB-2gzoA:19.70"],["1Y4L_B_SVRB301_2","PHOSPHOLIPASE A2 HOMOLOG 2","2gzo","UPF0301 PROTEIN SO3346","Shewanella oneidensis",5,"LEU A 103;LEU A 157;VAL A  85;GLY A  83;TYR A  26","None","1.32A","1y4lB-2gzoA:undetectable","1y4lB-2gzoA:19.47"],["2ZB8_A_IMNA800_1","PROSTAGLANDIN REDUCTASE 2","2gzo","UPF0301 PROTEIN SO3346","Shewanella oneidensis",5,"THR A  23;PHE A 158;LEU A  73;VAL A 126;LEU A 125","None","1.47A","2zb8A-2gzoA:0.0","2zb8A-2gzoA:19.67"],["5ESH_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2gzo","UPF0301 PROTEIN SO3346","Shewanella oneidensis",5,"ALA A  35;LEU A  27;GLY A  45;LEU A 128;PHE A  84","None","1.14A","5eshA-2gzoA:undetectable","5eshA-2gzoA:18.15"],["5HIE_A_P06A801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2gzo","UPF0301 PROTEIN SO3346","Shewanella oneidensis",6,"GLY A  76;LEU A 157;LEU A  27;ILE A  40;TRP A 147;GLY A  37","None","1.26A","5hieA-2gzoA:undetectable","5hieA-2gzoA:21.50"]]