SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2gzs IROE PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 160
LEU A  89
LEU A 185
 None
 0.67A 1mx1E-2gzsA:
11.3		 1mx1E-2gzsA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2gzs IROE PROTEIN
(Escherichia
coli) 		4 / 6 TYR A 119
TYR A 134
GLY A  91
ASN A  92
 None
 1.27A 2g72A-2gzsA:
undetectable		 2g72A-2gzsA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2gzs IROE PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 106
LEU A  86
MET A  95
THR A  76
 None
 1.24A 2oaxD-2gzsA:
undetectable		 2oaxD-2gzsA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2gzs IROE PROTEIN
(Escherichia
coli) 		4 / 7 SER A 210
VAL A 226
ILE A 241
TRP A 199
 None
 1.25A 2x45B-2gzsA:
undetectable		 2x45B-2gzsA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 2gzs IROE PROTEIN
(Escherichia
coli) 		4 / 7 SER A 210
VAL A 226
ILE A 241
TRP A 199
 None
 1.25A 2x45C-2gzsA:
undetectable		 2x45C-2gzsA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 ARG A 130
PHE A 291
HIS A 287
GLY A 288
GLY A 192
 DFP  A1189 (-2.8A)
None
DFP  A1189 (-3.8A)
None
None
 1.44A 2y6rC-2gzsA:
undetectable		 2y6rC-2gzsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2gzs IROE PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 204
GLU A 173
ASN A 177
 None
 0.97A 2y7hC-2gzsA:
undetectable		 2y7hC-2gzsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 136
GLY A 216
SER A 157
GLY A 192
GLY A 191
 None
DFP  A1189 (-3.6A)
None
None
None
 0.71A 3axzA-2gzsA:
undetectable		 3axzA-2gzsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2gzs IROE PROTEIN
(Escherichia
coli) 		4 / 7 SER A 210
VAL A 226
ILE A 241
TRP A 199
 None
 1.20A 3bu1A-2gzsA:
undetectable		 3bu1A-2gzsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 187
GLY A 192
LEU A 193
GLU A 243
ALA A 298
 None
 0.95A 3vywA-2gzsA:
undetectable		 3vywA-2gzsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 10 ARG A 130
PHE A 291
HIS A 287
GLY A 288
GLY A 192
 DFP  A1189 (-2.8A)
None
DFP  A1189 (-3.8A)
None
None
 1.48A 4a99A-2gzsA:
1.0		 4a99A-2gzsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 11 ARG A 130
PHE A 291
HIS A 287
GLY A 288
GLY A 192
 DFP  A1189 (-2.8A)
None
DFP  A1189 (-3.8A)
None
None
 1.50A 4a99B-2gzsA:
undetectable		 4a99B-2gzsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  82
GLN A 181
ARG A 183
ILE A 178
GLU A 173
 None
 1.04A 4azwA-2gzsA:
2.2		 4azwA-2gzsA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2gzs IROE PROTEIN
(Escherichia
coli) 		3 / 3 HIS A 238
VAL A 229
LEU A 270
 None
 0.71A 4m2vA-2gzsA:
undetectable		 4m2vA-2gzsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 2gzs IROE PROTEIN
(Escherichia
coli) 		4 / 8 MET A 242
LEU A 239
HIS A 238
ILE A 302
 None
 1.06A 4ok1A-2gzsA:
undetectable		 4ok1A-2gzsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 136
GLY A 216
SER A 157
GLY A 192
GLY A 191
 None
DFP  A1189 (-3.6A)
None
None
None
 0.67A 4yvgA-2gzsA:
2.2		 4yvgA-2gzsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2gzs IROE PROTEIN
(Escherichia
coli) 		4 / 8 PHE A 282
SER A 212
HIS A 188
LEU A 285
 None
None
DFP  A1189 ( 4.8A)
None
 0.94A 5dzkd-2gzsA:
undetectable
5dzkr-2gzsA:
undetectable		 5dzkd-2gzsA:
20.36
5dzkr-2gzsA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2gzs IROE PROTEIN
(Escherichia
coli) 		4 / 6 PHE A 282
SER A 212
HIS A 188
LEU A 285
 None
None
DFP  A1189 ( 4.8A)
None
 1.02A 5dzke-2gzsA:
undetectable
5dzks-2gzsA:
undetectable		 5dzke-2gzsA:
20.36
5dzks-2gzsA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gzs IROE PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 145
TYR A 190
SER A 154
 None
DFP  A1189 (-3.5A)
None
 0.86A 5iktA-2gzsA:
undetectable		 5iktA-2gzsA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 192
VAL A 226
THR A 227
ALA A 240
LEU A 239
 None
 0.97A 5kocA-2gzsA:
undetectable		 5kocA-2gzsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2gzs IROE PROTEIN
(Escherichia
coli) 		6 / 12 GLY A 192
LEU A 185
VAL A 226
THR A 227
ALA A 240
LEU A 239
 None
 1.33A 5kpcA-2gzsA:
undetectable		 5kpcA-2gzsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 MET A  95
ALA A  44
SER A  48
LEU A 103
TYR A  87
 None
 1.30A 5vlmH-2gzsA:
0.0		 5vlmH-2gzsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 136
GLY A 216
SER A 157
GLY A 192
GLY A 191
 None
DFP  A1189 (-3.6A)
None
None
None
 0.70A 5wyqA-2gzsA:
undetectable		 5wyqA-2gzsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 136
GLY A 216
SER A 157
GLY A 192
GLY A 191
 None
DFP  A1189 (-3.6A)
None
None
None
 0.81A 5zhmB-2gzsA:
2.7		 5zhmB-2gzsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 187
ALA A 211
ASP A 301
ILE A 302
LEU A  86
 None
 1.13A 6b3aA-2gzsA:
undetectable		 6b3aA-2gzsA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 187
ALA A 211
ASP A 301
ILE A 302
LEU A  86
 None
 1.15A 6b3bA-2gzsA:
undetectable		 6b3bA-2gzsA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 9 SER A 245
ALA A 211
SER A 212
ALA A 293
SER A 294
 None
 1.18A 6bklE-2gzsA:
undetectable
6bklF-2gzsA:
undetectable
6bklG-2gzsA:
undetectable
6bklH-2gzsA:
undetectable		 6bklE-2gzsA:
6.50
6bklF-2gzsA:
6.50
6bklG-2gzsA:
6.50
6bklH-2gzsA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2gzs IROE PROTEIN
(Escherichia
coli) 		5 / 6 SER A 245
ALA A 211
SER A 212
ALA A 293
SER A 294
 None
 1.15A 6bocA-2gzsA:
undetectable
6bocB-2gzsA:
undetectable
6bocC-2gzsA:
undetectable
6bocD-2gzsA:
undetectable		 6bocA-2gzsA:
6.50
6bocB-2gzsA:
6.50
6bocC-2gzsA:
6.50
6bocD-2gzsA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2gzs IROE PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 103
ASN A 292
LEU A 300
 None
 0.68A 6exiA-2gzsA:
2.8		 6exiA-2gzsA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2gzs IROE PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 281
SER A 212
SER A 214
 None
 0.80A 6mxtA-2gzsA:
undetectable		 6mxtA-2gzsA:
21.22