SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 9 ILE A  90
LEU A 140
VAL A 148
GLY A 149
ALA A 118
 None
 1.23A 1e7aA-2gzxA:
undetectable		 1e7aA-2gzxA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 5 HIS A   6
HIS A  63
HIS A 128
ASP A 204
 NI  A 300 (-3.3A)
None
NI  A 299 (-3.4A)
NI  A 300 ( 2.9A)
 0.68A 1e9yB-2gzxA:
2.6		 1e9yB-2gzxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 8 HIS A   8
HIS A 153
ILE A  59
HIS A   6
 NI  A 300 (-3.4A)
NI  A 299 (-3.5A)
None
NI  A 300 (-3.3A)
 0.95A 1ei6C-2gzxA:
undetectable		 1ei6C-2gzxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 6 HIS A   6
HIS A   8
HIS A  63
HIS A 128
ASP A 204
 NI  A 300 (-3.3A)
NI  A 300 (-3.4A)
None
NI  A 299 (-3.4A)
NI  A 300 ( 2.9A)
 0.76A 1fweC-2gzxA:
13.8		 1fweC-2gzxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 6 SER A 154
PHE A 181
GLU A 202
GLY A 177
 None
 1.17A 1icuA-2gzxA:
undetectable
1icuB-2gzxA:
undetectable		 1icuA-2gzxA:
22.46
1icuB-2gzxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		6 / 12 GLU A  92
HIS A  63
HIS A 128
HIS A 153
ASP A 204
PRO A 206
 NI  A 300 ( 2.8A)
None
NI  A 299 (-3.4A)
NI  A 299 (-3.5A)
NI  A 300 ( 2.9A)
None
 1.37A 1ituA-2gzxA:
14.3		 1ituA-2gzxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		6 / 12 GLU A  92
HIS A  63
HIS A 128
HIS A 153
ASP A 204
PRO A 206
 NI  A 300 ( 2.8A)
None
NI  A 299 (-3.4A)
NI  A 299 (-3.5A)
NI  A 300 ( 2.9A)
None
 1.38A 1ituB-2gzxA:
2.2		 1ituB-2gzxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 11 VAL A  87
VAL A  35
GLY A  58
TRP A  77
LEU A  81
 None
 1.39A 1jkhA-2gzxA:
undetectable
1jkhB-2gzxA:
undetectable		 1jkhA-2gzxA:
18.75
1jkhB-2gzxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 6 SER A 154
PHE A 181
GLU A 202
GLY A 177
 None
 1.10A 1kqbA-2gzxA:
undetectable
1kqbB-2gzxA:
undetectable		 1kqbA-2gzxA:
24.19
1kqbB-2gzxA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 6 SER A 154
PHE A 181
GLU A 202
GLY A 177
 None
 1.14A 1kqbC-2gzxA:
undetectable
1kqbD-2gzxA:
undetectable		 1kqbC-2gzxA:
24.19
1kqbD-2gzxA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 6 PHE A 181
GLU A 202
GLY A 177
SER A 154
 None
 1.10A 1kqbC-2gzxA:
undetectable
1kqbD-2gzxA:
undetectable		 1kqbC-2gzxA:
24.19
1kqbD-2gzxA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 12 GLY A 176
GLY A 177
ASP A 204
SER A 154
HIS A 153
 None
None
NI  A 300 ( 2.9A)
None
NI  A 299 (-3.5A)
 1.15A 1wg8B-2gzxA:
2.1		 1wg8B-2gzxA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 8 LEU A   2
LEU A 199
PRO A 210
VAL A 179
 None
 0.90A 2po5B-2gzxA:
2.2		 2po5B-2gzxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 9 VAL A 148
GLY A 149
GLY A 150
ILE A  59
ALA A 118
 None
 0.92A 2z0yA-2gzxA:
undetectable		 2z0yA-2gzxA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 9 VAL A 148
GLY A 149
GLY A 150
ILE A  59
ALA A 118
 None
 0.90A 2z0yB-2gzxA:
undetectable		 2z0yB-2gzxA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 12 LEU A 123
GLY A  89
LEU A 252
ILE A  60
LEU A 117
 None
 1.07A 2zbpA-2gzxA:
undetectable		 2zbpA-2gzxA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 12 VAL A   7
ALA A  46
VAL A 223
ILE A   3
THR A 203
 None
 1.12A 3czhA-2gzxA:
undetectable		 3czhA-2gzxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 5 LYS A 188
PRO A 187
SER A 154
LEU A 233
 None
 1.28A 3ijxH-2gzxA:
undetectable		 3ijxH-2gzxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 5 LYS A 188
PRO A 187
SER A 156
LEU A 233
 None
 1.28A 3ijxH-2gzxA:
undetectable		 3ijxH-2gzxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 5 LYS A 188
PRO A 187
SER A 154
LEU A 233
 None
 1.31A 3iluH-2gzxA:
undetectable		 3iluH-2gzxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 5 LYS A 188
PRO A 187
SER A 156
LEU A 233
 None
 1.37A 3iluH-2gzxA:
undetectable		 3iluH-2gzxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		6 / 9 ALA A 118
ILE A 115
MET A  93
GLY A  91
ILE A  60
LEU A 117
 None
 1.42A 3ogpA-2gzxA:
undetectable		 3ogpA-2gzxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		6 / 10 ALA A 118
ILE A 115
MET A  93
GLY A  91
ILE A  60
LEU A 117
 None
 1.42A 3ogpA-2gzxA:
undetectable		 3ogpA-2gzxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 5 PHE A 253
GLY A  91
ILE A  88
VAL A  87
 None
 0.83A 3wrkA-2gzxA:
undetectable		 3wrkA-2gzxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 12 GLY A  58
ILE A  59
ILE A  60
LEU A  49
HIS A  84
 None
 0.94A 4azvA-2gzxA:
undetectable		 4azvA-2gzxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		4 / 5 HIS A   6
HIS A  63
HIS A 128
ASP A 204
 NI  A 300 (-3.3A)
None
NI  A 299 (-3.4A)
NI  A 300 ( 2.9A)
 0.65A 4h9mA-2gzxA:
13.2		 4h9mA-2gzxA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		3 / 3 SER A 156
ASP A  96
ASP A 100
 None
 0.92A 4mwzA-2gzxA:
undetectable		 4mwzA-2gzxA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 6 HIS A   6
HIS A   8
HIS A  63
HIS A 128
ASP A 204
 NI  A 300 (-3.3A)
NI  A 300 (-3.4A)
None
NI  A 299 (-3.4A)
NI  A 300 ( 2.9A)
 0.64A 4ubpC-2gzxA:
3.0		 4ubpC-2gzxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 6 HIS A   8
HIS A  63
HIS A 128
HIS A 153
ASP A 204
 NI  A 300 (-3.4A)
None
NI  A 299 (-3.4A)
NI  A 299 (-3.5A)
NI  A 300 ( 2.9A)
 1.13A 4ubpC-2gzxA:
3.0		 4ubpC-2gzxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2gzx PUTATIVE TATD
RELATED DNASE
(Staphylococcus
aureus) 		5 / 11 LEU A 200
GLU A 243
LEU A 252
THR A 246
ALA A 249
 None
 1.09A 5o96A-2gzxA:
2.9
5o96B-2gzxA:
2.2		 5o96A-2gzxA:
23.15
5o96B-2gzxA:
23.15