SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 1.04A 1hsgB-2h00A:
undetectable		 1hsgB-2h00A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 PRO A  40
GLY A  73
GLY A  75
THR A  95
PRO A 148
 SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.3A)
None
 1.10A 1nv8A-2h00A:
17.6		 1nv8A-2h00A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		8 / 12 PRO A  40
ILE A  72
GLY A  73
GLY A  75
THR A  95
VAL A  97
ASN A 147
PRO A 149
 SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.3A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.9A)
SAH  A 300 (-4.0A)
 0.49A 1nv8A-2h00A:
17.6		 1nv8A-2h00A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		6 / 12 ILE A  72
GLY A  73
GLY A  75
THR A  95
VAL A  97
PRO A 149
 None
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.3A)
SAH  A 300 (-4.2A)
SAH  A 300 (-4.0A)
 0.47A 1nv8B-2h00A:
17.9		 1nv8B-2h00A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  73
GLY A  75
ASP A  98
ASN A 147
PRO A 149
 SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
None
SAH  A 300 (-3.9A)
SAH  A 300 (-4.0A)
 0.64A 1qaoA-2h00A:
11.8		 1qaoA-2h00A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		7 / 12 PRO A  40
ILE A  72
GLY A  75
THR A  95
VAL A  97
ASN A 147
PRO A 149
 SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
SAH  A 300 (-4.3A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.9A)
SAH  A 300 (-4.0A)
 0.53A 1sg9A-2h00A:
17.7		 1sg9A-2h00A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		6 / 12 PRO A  40
ILE A  72
GLY A  73
GLY A  75
VAL A  97
PRO A 149
 SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
SAH  A 300 (-4.0A)
 0.58A 1sg9B-2h00A:
17.7		 1sg9B-2h00A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		6 / 12 PRO A  40
ILE A  72
GLY A  75
VAL A  97
ASN A 147
PRO A 149
 SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.9A)
SAH  A 300 (-4.0A)
 0.55A 1sg9C-2h00A:
17.5		 1sg9C-2h00A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A  72
GLY A  75
THR A  95
VAL A  97
PRO A 149
 None
SAH  A 300 (-3.6A)
SAH  A 300 (-4.3A)
SAH  A 300 (-4.2A)
SAH  A 300 (-4.0A)
 0.48A 1vq1A-2h00A:
17.7		 1vq1A-2h00A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		6 / 12 ILE A  72
GLY A  73
GLY A  75
SER A  77
VAL A  97
PRO A 149
 None
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 ( 4.2A)
SAH  A 300 (-4.2A)
SAH  A 300 (-4.0A)
 0.76A 1vq1B-2h00A:
17.7		 1vq1B-2h00A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 10 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.98A 2aquA-2h00A:
undetectable		 2aquA-2h00A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.98A 2f80B-2h00A:
undetectable		 2f80B-2h00A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  75
VAL A  97
ASP A  98
PRO A 149
PHE A 190
 SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-4.0A)
SAH  A 300 (-4.9A)
 1.00A 2f8lA-2h00A:
12.9		 2f8lA-2h00A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A  71
GLY A  73
GLY A  75
ASP A  98
ASN A 147
 SAH  A 300 ( 4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
None
SAH  A 300 (-3.9A)
 0.41A 2nxeA-2h00A:
9.1		 2nxeA-2h00A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A  71
GLY A  73
GLY A  75
ASP A  98
ASN A 147
 SAH  A 300 ( 4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
None
SAH  A 300 (-3.9A)
 0.36A 2nxeB-2h00A:
8.3		 2nxeB-2h00A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.92A 2pymA-2h00A:
undetectable		 2pymA-2h00A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.93A 2pymB-2h00A:
undetectable		 2pymB-2h00A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.92A 2pynA-2h00A:
undetectable		 2pynA-2h00A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.92A 2pynB-2h00A:
undetectable		 2pynB-2h00A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.91A 2q63B-2h00A:
undetectable		 2q63B-2h00A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.95A 2qakB-2h00A:
undetectable		 2qakB-2h00A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.94A 2qhcB-2h00A:
undetectable		 2qhcB-2h00A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.91A 2z54B-2h00A:
undetectable		 2z54B-2h00A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  73
GLY A  75
SER A  77
ASP A  98
ASN A 147
 SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 ( 4.2A)
None
SAH  A 300 (-3.9A)
 0.68A 3cjtO-2h00A:
7.1		 3cjtO-2h00A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.93A 3cywA-2h00A:
undetectable		 3cywA-2h00A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.93A 3cyxA-2h00A:
undetectable		 3cyxA-2h00A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.90A 3cyxB-2h00A:
undetectable		 3cyxB-2h00A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.98A 3d1xB-2h00A:
undetectable		 3d1xB-2h00A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 11 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.85A 3em4A-2h00A:
undetectable		 3em4A-2h00A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 11 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.91A 3em4U-2h00A:
undetectable		 3em4U-2h00A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  73
GLY A  75
GLU A  96
ASP A  98
PRO A 149
 SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-2.8A)
None
SAH  A 300 (-4.0A)
 0.71A 3fuuA-2h00A:
12.8		 3fuuA-2h00A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		6 / 11 GLY A  73
GLY A  75
GLU A  96
ASP A  98
ASN A 147
PRO A 149
 SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-2.8A)
None
SAH  A 300 (-3.9A)
SAH  A 300 (-4.0A)
 0.78A 3grvA-2h00A:
12.5		 3grvA-2h00A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.95A 3lzsA-2h00A:
undetectable		 3lzsA-2h00A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 1.00A 3lzsB-2h00A:
undetectable		 3lzsB-2h00A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.98A 3lzuA-2h00A:
undetectable		 3lzuA-2h00A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 1.00A 3pwmA-2h00A:
undetectable		 3pwmA-2h00A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 1.03A 3tkgC-2h00A:
undetectable		 3tkgC-2h00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
 None
None
None
DTU  A2140 (-4.0A)
None
 0.98A 3tkwA-2h00A:
undetectable		 3tkwA-2h00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 11 ASP A  71
GLY A  73
GLY A  75
ASN A 147
PRO A 149
 SAH  A 300 ( 4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-3.9A)
SAH  A 300 (-4.0A)
 0.66A 4dcmA-2h00A:
14.4		 4dcmA-2h00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		3 / 3 ARG A  67
GLU A  53
ARG A 206
 None
 0.96A 4mwvA-2h00A:
undetectable		 4mwvA-2h00A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 129
ALA A 132
LEU A 128
VAL A 121
 None
None
SAH  A 300 (-4.7A)
None
 1.06A 5a6iA-2h00A:
undetectable		 5a6iA-2h00A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 143
GLY A  89
ASP A 142
ILE A  56
 None
 0.90A 5ik1A-2h00A:
undetectable		 5ik1A-2h00A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 8 VAL A  42
LEU A  83
CYH A  20
ILE A  31
 None
 0.88A 5y1yA-2h00A:
undetectable		 5y1yA-2h00A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  23
ASN A  47
LEU A  87
 None
 0.68A 6exiA-2h00A:
6.7		 6exiA-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  23
ASN A  88
LEU A 114
 None
 0.56A 6exiA-2h00A:
6.7		 6exiA-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 10 GLY A  73
GLU A  96
VAL A  97
ASP A  98
CYH A 101
 SAH  A 300 (-3.1A)
SAH  A 300 (-2.8A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
 0.39A 6exiA-2h00A:
6.6		 6exiA-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 10 GLY A  73
GLY A  75
VAL A  97
ASP A  98
CYH A 101
 SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
 1.19A 6exiA-2h00A:
6.6		 6exiA-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 10 GLY A  73
GLU A  96
VAL A  97
ASP A  98
CYH A 101
 SAH  A 300 (-3.1A)
SAH  A 300 (-2.8A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
 0.38A 6exiB-2h00A:
4.6		 6exiB-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 10 GLY A  73
GLY A  75
VAL A  97
ASP A  98
CYH A 101
 SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
 1.16A 6exiB-2h00A:
4.6		 6exiB-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  73
GLU A  96
VAL A  97
ASP A  98
CYH A 101
 SAH  A 300 (-3.1A)
SAH  A 300 (-2.8A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
 0.37A 6exiC-2h00A:
4.5
6exiD-2h00A:
4.5		 6exiC-2h00A:
15.60
6exiD-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  73
GLY A  75
VAL A  97
ASP A  98
CYH A 101
 SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
 1.20A 6exiC-2h00A:
4.5
6exiD-2h00A:
4.5		 6exiC-2h00A:
15.60
6exiD-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  73
GLU A  96
VAL A  97
ASP A  98
CYH A 101
 SAH  A 300 (-3.1A)
SAH  A 300 (-2.8A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
 0.39A 6exiC-2h00A:
4.5
6exiD-2h00A:
4.4		 6exiC-2h00A:
15.60
6exiD-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  73
GLY A  75
VAL A  97
ASP A  98
CYH A 101
 SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-3.6A)
 1.20A 6exiC-2h00A:
4.5
6exiD-2h00A:
4.4		 6exiC-2h00A:
15.60
6exiD-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 10 ASP A  71
GLY A  73
GLY A  75
ASN A 147
PHE A 190
 SAH  A 300 ( 4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.6A)
SAH  A 300 (-3.9A)
SAH  A 300 (-4.9A)
 0.89A 6nqaK-2h00A:
9.8		 6nqaK-2h00A:
21.56