SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 6 GLN A1952
CYH A1904
VAL A1801
GLY A1912
 None
3UN  A 401 (-3.3A)
None
None
 1.27A 1ekjC-2h03A:
undetectable
1ekjD-2h03A:
undetectable		 1ekjC-2h03A:
23.38
1ekjD-2h03A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 6 CYH A1904
VAL A1801
GLY A1912
GLN A1952
 3UN  A 401 (-3.3A)
None
None
None
 1.23A 1ekjC-2h03A:
undetectable
1ekjD-2h03A:
undetectable		 1ekjC-2h03A:
23.38
1ekjD-2h03A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 10 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.32A 1fohA-2h03A:
undetectable		 1fohA-2h03A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 10 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.32A 1fohB-2h03A:
undetectable		 1fohB-2h03A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 10 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.33A 1fohC-2h03A:
undetectable		 1fohC-2h03A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 10 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.34A 1fohD-2h03A:
undetectable		 1fohD-2h03A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 12 GLY A1912
VAL A1947
VAL A1884
LEU A1956
LEU A1921
 None
 1.19A 1mx1E-2h03A:
undetectable		 1mx1E-2h03A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 10 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.32A 1pn0A-2h03A:
undetectable		 1pn0A-2h03A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 10 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.32A 1pn0B-2h03A:
undetectable		 1pn0B-2h03A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 10 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.35A 1pn0C-2h03A:
1.1		 1pn0C-2h03A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 10 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.34A 1pn0D-2h03A:
1.3		 1pn0D-2h03A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 8 TYR A1865
THR A1876
CYH A1959
TRP A1868
 None
 1.26A 1uw6A-2h03A:
undetectable
1uw6B-2h03A:
undetectable		 1uw6A-2h03A:
20.60
1uw6B-2h03A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 8 TYR A1865
THR A1876
CYH A1959
TRP A1868
 None
 1.28A 1uw6D-2h03A:
undetectable
1uw6E-2h03A:
undetectable		 1uw6D-2h03A:
20.60
1uw6E-2h03A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 8 TYR A1865
THR A1876
CYH A1959
TRP A1868
 None
 1.24A 1uw6G-2h03A:
undetectable
1uw6H-2h03A:
undetectable		 1uw6G-2h03A:
20.60
1uw6H-2h03A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 8 TYR A1865
THR A1876
CYH A1959
TRP A1868
 None
 1.22A 1uw6P-2h03A:
undetectable
1uw6Q-2h03A:
undetectable		 1uw6P-2h03A:
20.60
1uw6Q-2h03A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 8 TRP A1868
TYR A1865
THR A1876
CYH A1959
 None
 1.31A 1uw6P-2h03A:
undetectable
1uw6T-2h03A:
undetectable		 1uw6P-2h03A:
20.60
1uw6T-2h03A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 7 TYR A1733
VAL A1908
GLY A1909
THR A1949
 3UN  A 401 (-3.8A)
3UN  A 401 (-3.8A)
3UN  A 401 (-3.5A)
None
 0.93A 2a1mA-2h03A:
undetectable		 2a1mA-2h03A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		3 / 3 ASN A1731
ASN A1759
ARG A1943
 None
 0.65A 2rlcA-2h03A:
undetectable		 2rlcA-2h03A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 7 TYR A1865
TRP A1868
VAL A1873
CYH A1959
 None
 1.28A 2xz5B-2h03A:
undetectable
2xz5E-2h03A:
undetectable		 2xz5B-2h03A:
21.80
2xz5E-2h03A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 8 TYR A1865
TRP A1868
VAL A1873
CYH A1959
 None
 1.30A 2xz5C-2h03A:
undetectable
2xz5D-2h03A:
undetectable		 2xz5C-2h03A:
21.80
2xz5D-2h03A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		4 / 7 TYR A1865
TRP A1868
VAL A1873
CYH A1959
 None
 1.28A 2xz5D-2h03A:
undetectable
2xz5E-2h03A:
undetectable		 2xz5D-2h03A:
21.80
2xz5E-2h03A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		3 / 3 ARG A1743
ASP A1785
ASN A1727
 None
MG  A 304 ( 3.8A)
None
 0.82A 2zzmA-2h03A:
undetectable		 2zzmA-2h03A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		5 / 11 ILE A1773
ILE A1798
ILE A1758
VAL A1795
PRO A1899
 None
 0.99A 3tmzA-2h03A:
undetectable		 3tmzA-2h03A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		3 / 3 ALA A1935
GLN A1952
GLY A1872
 None
 0.64A 4odoC-2h03A:
undetectable		 4odoC-2h03A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens) 		3 / 3 THR A1802
GLU A1806
HIS A1871
 None
None
3UN  A 401 (-3.9A)
 0.91A 5xioA-2h03A:
undetectable		 5xioA-2h03A:
19.77