SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 5 PHE A  77
TYR A  78
VAL A 148
VAL A 197
 None
 1.22A 1dz6B-2h0aA:
undetectable		 1dz6B-2h0aA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 4 GLY A 166
LEU A 164
GLY A 204
ARG A 167
 None
 0.68A 1j7kA-2h0aA:
2.6		 1j7kA-2h0aA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 8 PHE A  77
TYR A  78
VAL A 148
VAL A 197
 None
 1.18A 1uyuA-2h0aA:
undetectable		 1uyuA-2h0aA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 8 PHE A  77
TYR A  78
VAL A 148
VAL A 197
 None
 1.18A 1uyuB-2h0aA:
undetectable		 1uyuB-2h0aA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 5 PHE A  77
TYR A  78
VAL A 148
VAL A 197
 None
 1.23A 2m56A-2h0aA:
undetectable		 2m56A-2h0aA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 12 GLY A 301
GLY A  84
GLU A  83
ASP A 149
VAL A 148
 None
 1.20A 2wa2A-2h0aA:
undetectable		 2wa2A-2h0aA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 6 PHE A  77
TYR A  78
VAL A 148
VAL A 197
 None
 1.20A 2zawA-2h0aA:
undetectable		 2zawA-2h0aA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 12 ALA A 169
PRO A 326
GLY A 281
LEU A 328
VAL A 329
 None
 1.23A 2zifA-2h0aA:
3.4		 2zifA-2h0aA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 12 ALA A 169
PRO A 326
GLY A 281
LEU A 328
VAL A 329
 None
 1.19A 2zifB-2h0aA:
3.3		 2zifB-2h0aA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 8 LEU A 266
VAL A 248
LEU A 246
VAL A 276
 None
 0.83A 2zujA-2h0aA:
undetectable		 2zujA-2h0aA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		3 / 3 ARG A 154
GLU A 321
ASP A 161
 None
 0.60A 3g2oA-2h0aA:
2.1		 3g2oA-2h0aA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 6 ARG A 214
PHE A 181
ASP A 219
PRO A 179
 None
 1.36A 3jqaC-2h0aA:
2.5		 3jqaC-2h0aA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 5 VAL A  88
LEU A  89
ILE A 124
ALA A 304
 None
 0.94A 3n8yB-2h0aA:
undetectable		 3n8yB-2h0aA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 8 PHE A  77
TYR A  78
VAL A 148
VAL A 197
 None
 1.15A 4l4eA-2h0aA:
undetectable		 4l4eA-2h0aA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 8 ALA A 285
PHE A  77
VAL A 197
PHE A 198
 None
 0.89A 4ltwA-2h0aA:
undetectable		 4ltwA-2h0aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 11 LEU A 260
ARG A 331
LEU A 277
ASP A 253
LEU A 257
 None
 1.32A 4or0A-2h0aA:
undetectable		 4or0A-2h0aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y9T_A_PA1A401_1
(ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 12 ASP A 280
GLN A 295
ASP A 149
TYR A  78
HIS A 282
 None
 1.40A 4y9tA-2h0aA:
22.1		 4y9tA-2h0aA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		3 / 3 LEU A 139
ARG A 138
ARG A 154
 None
 0.97A 4yiaB-2h0aA:
undetectable		 4yiaB-2h0aA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		3 / 3 VAL A 329
THR A 292
ARG A 331
 None
 0.68A 5b2sB-2h0aA:
undetectable		 5b2sB-2h0aA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		3 / 3 VAL A 329
THR A 292
ARG A 331
 None
 0.69A 5b2tB-2h0aA:
undetectable		 5b2tB-2h0aA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		3 / 3 LEU A 246
LEU A 235
ARG A 331
 None
 0.66A 5hnzB-2h0aA:
undetectable		 5hnzB-2h0aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		6 / 12 ILE A 183
ALA A 184
PHE A 238
LEU A 221
GLY A 258
VAL A 259
 None
 1.39A 5i73A-2h0aA:
undetectable		 5i73A-2h0aA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 6 PHE A 284
PRO A 283
ARG A 331
THR A 292
 None
 1.21A 5ih0A-2h0aA:
undetectable		 5ih0A-2h0aA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		4 / 7 ILE A 124
LEU A 308
MET A 312
LEU A 309
 None
 0.96A 5u4sA-2h0aA:
2.8		 5u4sA-2h0aA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2h0a TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 11 GLU A 310
GLY A 301
ALA A 302
ILE A 124
VAL A 148
 None
 1.19A 5yk2A-2h0aA:
undetectable		 5yk2A-2h0aA:
22.47