SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		4 / 7 LEU A 195
ALA A 197
PHE A 104
TYR A 205
 None
 0.78A 1epbA-2h0iA:
undetectable		 1epbA-2h0iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		4 / 8 LEU A 195
ALA A 197
PHE A 104
TYR A 205
 None
 0.77A 1epbB-2h0iA:
undetectable		 1epbB-2h0iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		5 / 12 GLY A  14
VAL A   7
ILE A  17
GLY A  32
ILE A  10
 None
 0.88A 2f8gB-2h0iA:
undetectable		 2f8gB-2h0iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		5 / 12 GLY A  14
VAL A   7
ILE A  17
GLY A  32
ILE A  10
 None
 0.89A 2o4lB-2h0iA:
undetectable		 2o4lB-2h0iA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		4 / 5 SER A  64
TYR A  42
PHE A  21
TYR A  54
 None
 1.42A 2x7hA-2h0iA:
undetectable		 2x7hA-2h0iA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		4 / 5 SER A  64
TYR A  42
PHE A  21
TYR A  54
 None
 1.40A 2x7hB-2h0iA:
undetectable		 2x7hB-2h0iA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		5 / 10 GLY A  14
VAL A   7
ILE A  17
GLY A  32
ILE A  10
 None
 0.87A 3ekpD-2h0iA:
undetectable		 3ekpD-2h0iA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		3 / 3 THR A 145
ASP A 106
GLU A 189
 None
 0.70A 3qowA-2h0iA:
undetectable		 3qowA-2h0iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		3 / 3 TYR A 111
LEU A 169
LYS A 168
 None
 0.74A 3sueD-2h0iA:
undetectable		 3sueD-2h0iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		4 / 8 PRO A 107
VAL A 177
VAL A 173
LEU A 185
 None
 0.95A 4pwdA-2h0iA:
undetectable		 4pwdA-2h0iA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		3 / 3 THR A 145
ASP A 106
GLU A 189
 None
 0.57A 5fa8A-2h0iA:
undetectable		 5fa8A-2h0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG
(Escherichia
coli) 		4 / 5 GLY A 136
ASP A 106
MET A  84
MET A  80
 None
 1.43A 5gwkA-2h0iA:
undetectable		 5gwkA-2h0iA:
14.85