SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		4 / 8 ALA A 511
LEU A 509
LEU A 474
LEU A 471
 None
 0.92A 1dvtA-2h0qA:
undetectable
1dvtB-2h0qA:
undetectable		 1dvtA-2h0qA:
18.22
1dvtB-2h0qA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		3 / 3 ARG A 405
VAL A 387
GLY A 381
 None
 0.66A 2avvE-2h0qA:
undetectable		 2avvE-2h0qA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		5 / 12 ARG A 541
GLU A 533
SER A 567
VAL A 588
TYR A 535
 None
 1.19A 3g0bA-2h0qA:
undetectable		 3g0bA-2h0qA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		5 / 12 ARG A 541
GLU A 533
SER A 567
VAL A 588
TYR A 535
 None
 1.21A 3g0bB-2h0qA:
undetectable		 3g0bB-2h0qA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		5 / 12 ARG A 541
GLU A 533
SER A 567
VAL A 588
TYR A 535
 None
 1.17A 3g0bC-2h0qA:
undetectable		 3g0bC-2h0qA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		5 / 12 ARG A 541
GLU A 533
SER A 567
VAL A 588
TYR A 535
 None
 1.20A 3g0bD-2h0qA:
2.1		 3g0bD-2h0qA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		4 / 7 ILE A 524
SER A 458
GLU A 490
LEU A 500
 None
 0.80A 3ua5B-2h0qA:
undetectable		 3ua5B-2h0qA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		4 / 7 PHE A 599
ALA A 444
PRO A 617
LEU A 619
 None
 0.94A 5dzkD-2h0qA:
undetectable
5dzkR-2h0qA:
undetectable		 5dzkD-2h0qA:
19.23
5dzkR-2h0qA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		5 / 8 ILE A 549
ALA A 564
VAL A 377
VAL A 545
GLU A 485
 None
 1.33A 5ecnD-2h0qA:
undetectable		 5ecnD-2h0qA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		5 / 11 ALA A 467
THR A 466
VAL A 455
GLY A 442
GLY A 473
 None
 0.88A 5lf7K-2h0qA:
undetectable
5lf7L-2h0qA:
undetectable		 5lf7K-2h0qA:
20.59
5lf7L-2h0qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		5 / 11 ALA A 467
THR A 466
VAL A 455
GLY A 442
GLY A 473
 None
 0.90A 5lf7Y-2h0qA:
undetectable
5lf7Z-2h0qA:
undetectable		 5lf7Y-2h0qA:
20.59
5lf7Z-2h0qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1
(Mus
musculus) 		4 / 7 ILE A 452
VAL A 455
ILE A 470
THR A 466
 None
 0.98A 6cduF-2h0qA:
undetectable
6cduG-2h0qA:
undetectable		 6cduF-2h0qA:
22.48
6cduG-2h0qA:
22.48