SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A 154
HIS A  44
THR A   3
ILE A   5
 None
 0.81A 1c9sU-2h0rA:
undetectable
1c9sV-2h0rA:
undetectable		 1c9sU-2h0rA:
17.59
1c9sV-2h0rA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 201
ASP A 195
GLU A 165
TYR A 166
 None
 1.33A 1yc2A-2h0rA:
5.0
1yc2B-2h0rA:
4.2
1yc2E-2h0rA:
0.8		 1yc2A-2h0rA:
21.77
1yc2B-2h0rA:
21.77
1yc2E-2h0rA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A  19
ASP A  51
CYH A 167
 None
ZN  A 301 (-2.6A)
None
 0.91A 2br4E-2h0rA:
undetectable		 2br4E-2h0rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  94
ILE A 192
GLU A 129
ASP A  51
ASP A   8
 ZN  A 301 (-3.4A)
None
ZN  A 301 ( 3.9A)
ZN  A 301 (-2.6A)
None
 1.15A 2pgrA-2h0rA:
undetectable		 2pgrA-2h0rA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 10 ASP A   8
ASP A  51
HIS A  53
TYR A 131
CYH A 167
 None
ZN  A 301 (-2.6A)
ZN  A 301 (-3.2A)
None
None
 1.27A 2wt9A-2h0rA:
30.3		 2wt9A-2h0rA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		9 / 10 ASP A   8
PHE A  13
LEU A  20
ASP A  51
TRP A  91
HIS A  94
TYR A 131
ALA A 163
CYH A 167
 None
None
None
ZN  A 301 (-2.6A)
None
ZN  A 301 (-3.4A)
None
None
None
 0.37A 2wt9A-2h0rA:
30.3		 2wt9A-2h0rA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_B_NIOB1216_1
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		8 / 9 ASP A   8
PHE A  13
LEU A  20
ASP A  51
TRP A  91
HIS A  94
ALA A 163
CYH A 167
 None
None
None
ZN  A 301 (-2.6A)
None
ZN  A 301 (-3.4A)
None
None
 0.35A 2wt9B-2h0rA:
30.2		 2wt9B-2h0rA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 135
ALA A 170
ALA A 172
THR A 182
 None
 0.99A 2xfhA-2h0rA:
undetectable		 2xfhA-2h0rA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A   8
ASP A  51
GLU A 129
HIS A  53
TYR A 131
 None
ZN  A 301 (-2.6A)
ZN  A 301 ( 3.9A)
ZN  A 301 (-3.2A)
None
 1.45A 3o94A-2h0rA:
23.4		 3o94A-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A   8
PHE A  13
ASP A  51
GLU A 129
TYR A 131
 None
None
ZN  A 301 (-2.6A)
ZN  A 301 ( 3.9A)
None
 1.02A 3o94A-2h0rA:
23.4		 3o94A-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		6 / 11 ASP A   8
PHE A  13
LEU A  20
ASP A  51
HIS A  94
TYR A 131
 None
None
None
ZN  A 301 (-2.6A)
ZN  A 301 (-3.4A)
None
 0.52A 3o94A-2h0rA:
23.4		 3o94A-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A   8
ASP A  51
GLU A 129
HIS A  53
TYR A 131
 None
ZN  A 301 (-2.6A)
ZN  A 301 ( 3.9A)
ZN  A 301 (-3.2A)
None
 1.44A 3o94B-2h0rA:
23.3		 3o94B-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A   8
PHE A  13
ASP A  51
GLU A 129
TYR A 131
 None
None
ZN  A 301 (-2.6A)
ZN  A 301 ( 3.9A)
None
 1.03A 3o94B-2h0rA:
23.3		 3o94B-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		6 / 11 ASP A   8
PHE A  13
LEU A  20
ASP A  51
HIS A  94
TYR A 131
 None
None
None
ZN  A 301 (-2.6A)
ZN  A 301 (-3.4A)
None
 0.49A 3o94B-2h0rA:
23.3		 3o94B-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A   8
ASP A  51
GLU A 129
HIS A  53
TYR A 131
 None
ZN  A 301 (-2.6A)
ZN  A 301 ( 3.9A)
ZN  A 301 (-3.2A)
None
 1.47A 3o94C-2h0rA:
23.2		 3o94C-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A   8
PHE A  13
ASP A  51
GLU A 129
TYR A 131
 None
None
ZN  A 301 (-2.6A)
ZN  A 301 ( 3.9A)
None
 1.04A 3o94C-2h0rA:
23.2		 3o94C-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		6 / 11 ASP A   8
PHE A  13
LEU A  20
ASP A  51
HIS A  94
TYR A 131
 None
None
None
ZN  A 301 (-2.6A)
ZN  A 301 (-3.4A)
None
 0.50A 3o94C-2h0rA:
23.2		 3o94C-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A   8
ASP A  51
GLU A 129
HIS A  53
TYR A 131
 None
ZN  A 301 (-2.6A)
ZN  A 301 ( 3.9A)
ZN  A 301 (-3.2A)
None
 1.46A 3o94D-2h0rA:
23.2		 3o94D-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A   8
PHE A  13
ASP A  51
GLU A 129
TYR A 131
 None
None
ZN  A 301 (-2.6A)
ZN  A 301 ( 3.9A)
None
 1.04A 3o94D-2h0rA:
23.2		 3o94D-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		6 / 11 ASP A   8
PHE A  13
LEU A  20
ASP A  51
HIS A  94
TYR A 131
 None
None
None
ZN  A 301 (-2.6A)
ZN  A 301 (-3.4A)
None
 0.50A 3o94D-2h0rA:
23.2		 3o94D-2h0rA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_A_NIOA311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		7 / 9 ASP A   8
LEU A  20
ASP A  51
TRP A  91
HIS A  94
LYS A 122
ALA A 163
 None
None
ZN  A 301 (-2.6A)
None
ZN  A 301 (-3.4A)
None
None
 0.36A 3r2jA-2h0rA:
28.3		 3r2jA-2h0rA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		9 / 11 ASP A   8
PHE A  13
LEU A  20
ASP A  51
TRP A  91
HIS A  94
LYS A 122
TYR A 131
ALA A 163
 None
None
None
ZN  A 301 (-2.6A)
None
ZN  A 301 (-3.4A)
None
None
None
 0.34A 3r2jB-2h0rA:
27.6		 3r2jB-2h0rA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		10 / 12 ASP A   8
PHE A  13
LEU A  20
ASP A  51
HIS A  53
TRP A  91
HIS A  94
LYS A 122
TYR A 131
ALA A 163
 None
None
None
ZN  A 301 (-2.6A)
ZN  A 301 (-3.2A)
None
ZN  A 301 (-3.4A)
None
None
None
 0.30A 3r2jC-2h0rA:
28.4		 3r2jC-2h0rA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		9 / 11 ASP A   8
PHE A  13
LEU A  20
ASP A  51
TRP A  91
HIS A  94
LYS A 122
TYR A 131
ALA A 163
 None
None
None
ZN  A 301 (-2.6A)
None
ZN  A 301 (-3.4A)
None
None
None
 0.34A 3r2jD-2h0rA:
28.1		 3r2jD-2h0rA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  46
SER A  33
ILE A  32
VAL A   6
VAL A 160
 None
 1.18A 3rf4A-2h0rA:
undetectable
3rf4B-2h0rA:
undetectable		 3rf4A-2h0rA:
17.14
3rf4B-2h0rA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 8 ILE A  89
VAL A 160
ILE A  32
ILE A  14
ASP A   8
 None
 1.05A 5hi2A-2h0rA:
undetectable		 5hi2A-2h0rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 199
LEU A  20
PHE A  13
ASP A 194
 None
 0.88A 5hieB-2h0rA:
undetectable		 5hieB-2h0rA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 192
VAL A 198
VAL A 202
SER A 193
TYR A  70
 None
 1.18A 5n0oA-2h0rA:
2.2		 5n0oA-2h0rA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 192
VAL A 198
VAL A 202
SER A 193
TYR A  70
 None
 1.10A 5n0sB-2h0rA:
1.4		 5n0sB-2h0rA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 166
PRO A 191
LEU A 164
 None
 0.93A 6beoA-2h0rA:
undetectable		 6beoA-2h0rA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 101
GLN A 103
THR A  99
SER A  19
 None
 1.11A 6eqpA-2h0rA:
undetectable		 6eqpA-2h0rA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2h0r NICOTINAMIDASE
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 170
TYR A 131
GLN A  86
ILE A 137
 None
 1.33A 6g9bA-2h0rA:
undetectable
6g9bB-2h0rA:
undetectable		 6g9bA-2h0rA:
19.34
6g9bB-2h0rA:
13.55