SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 HIS A 272
ASN A 369
ASP A 320
GLY A 273
 CMX  A5001 ( 3.7A)
CMX  A5001 (-3.3A)
None
CMX  A5001 ( 3.9A)
 1.00A 2f6dA-2h12A:
undetectable		 2f6dA-2h12A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		3 / 3 ILE A 232
ILE A 325
LEU A 206
 None
 0.55A 2prgA-2h12A:
undetectable		 2prgA-2h12A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 11 LEU A 391
LEU A 267
ILE A 230
THR A 243
VAL A 370
 None
 1.10A 2qd3A-2h12A:
undetectable		 2qd3A-2h12A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 11 MET A 381
ILE A 377
LEU A 231
ASN A 200
LEU A 233
 None
 1.13A 3a50C-2h12A:
undetectable		 3a50C-2h12A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 MET A 381
ILE A 377
LEU A 231
ASN A 200
LEU A 233
 None
 1.10A 3a50E-2h12A:
undetectable		 3a50E-2h12A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A  97
HIS A  76
ASP A 236
LEU A  74
GLY A  78
 None
 1.30A 3g1uB-2h12A:
undetectable		 3g1uB-2h12A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A  97
HIS A  76
ASP A 236
LEU A  74
GLY A  78
 None
 1.32A 3g1uC-2h12A:
undetectable		 3g1uC-2h12A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A  97
HIS A  76
ASP A 236
LEU A  74
GLY A  78
 None
 1.28A 3g1uD-2h12A:
undetectable		 3g1uD-2h12A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A  97
HIS A  76
ASP A 236
LEU A  74
GLY A  78
 None
 1.23A 3glqA-2h12A:
undetectable		 3glqA-2h12A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A  97
HIS A  76
ASP A 236
LEU A  74
GLY A  78
 None
 1.28A 3glqB-2h12A:
undetectable		 3glqB-2h12A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 4 LEU A 115
MET A 227
ILE A 260
ASP A 236
 None
 1.10A 3hecA-2h12A:
1.3		 3hecA-2h12A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A  97
HIS A  76
ASP A 236
LEU A  74
GLY A  78
 None
 1.15A 3n58A-2h12A:
undetectable		 3n58A-2h12A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 TYR A 153
GLU A 123
PRO A 195
TYR A 194
 SO4  A5014 (-4.4A)
None
None
None
 1.25A 3ugrA-2h12A:
undetectable		 3ugrA-2h12A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.78A 4iqqA-2h12A:
undetectable		 4iqqA-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.79A 4iqqB-2h12A:
undetectable		 4iqqB-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.83A 4iqqC-2h12A:
undetectable		 4iqqC-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 8 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.80A 4iqqD-2h12A:
undetectable		 4iqqD-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 8 ASN A  87
PRO A  80
LEU A  96
LEU A 102
 None
 0.97A 4jjkA-2h12A:
undetectable		 4jjkA-2h12A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		3 / 3 ILE A 292
MET A 282
ARG A 285
 None
 0.92A 4lnwA-2h12A:
undetectable		 4lnwA-2h12A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		3 / 3 ILE A 292
MET A 282
ARG A 285
 None
 0.91A 4lnxA-2h12A:
undetectable		 4lnxA-2h12A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 8 VAL A  35
ASP A  34
GLY A  29
ALA A  58
 None
 0.75A 4m48A-2h12A:
undetectable		 4m48A-2h12A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 ILE A 383
ALA A 380
LEU A 337
ARG A 229
PRO A 221
 None
None
None
None
SO4  A5047 (-4.2A)
 1.05A 4m6kA-2h12A:
undetectable		 4m6kA-2h12A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		3 / 3 VAL A 333
LEU A 337
VAL A 222
 None
None
SO4  A5047 ( 4.8A)
 0.56A 4wq4A-2h12A:
undetectable		 4wq4A-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 ILE A 230
HIS A 234
LEU A 391
GLY A 375
 None
 1.04A 4z69A-2h12A:
undetectable		 4z69A-2h12A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		3 / 3 TRP A 404
ARG A 165
LEU A  98
 None
 0.63A 5dbyA-2h12A:
undetectable		 5dbyA-2h12A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		3 / 3 MET A 326
HIS A 234
GLY A 375
 None
 0.83A 5gwzB-2h12A:
undetectable		 5gwzB-2h12A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 ILE A  81
HIS A  76
THR A 243
ALA A  88
PHE A 392
 None
None
None
None
CMX  A5001 (-4.9A)
 1.39A 5iwuA-2h12A:
undetectable		 5iwuA-2h12A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.79A 5nooA-2h12A:
undetectable		 5nooA-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.81A 5nooB-2h12A:
undetectable		 5nooB-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 6 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.82A 5nooC-2h12A:
undetectable		 5nooC-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 8 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.82A 5nooD-2h12A:
undetectable		 5nooD-2h12A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		3 / 3 LEU A 351
ALA A 348
LEU A 308
 None
None
CMX  A5001 (-4.9A)
 0.45A 5uunB-2h12A:
undetectable		 5uunB-2h12A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A  97
HIS A  76
ASP A 236
LEU A  74
GLY A  78
 None
 1.29A 6aphA-2h12A:
undetectable		 6aphA-2h12A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 10 VAL A  93
GLU A  86
LEU A 233
ILE A  81
HIS A  76
 None
 1.33A 6d9hR-2h12A:
1.2		 6d9hR-2h12A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A  97
HIS A  76
ASP A 236
LEU A  74
GLY A  78
 None
 1.22A 6gbnB-2h12A:
undetectable		 6gbnB-2h12A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 12 LEU A 356
GLU A 352
LEU A 308
GLY A 312
PHE A 319
 None
None
CMX  A5001 (-4.9A)
CMX  A5001 (-3.3A)
None
 1.13A 6gbnB-2h12A:
undetectable		 6gbnB-2h12A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 5 HIS A 237
ARG A 322
PHE A 392
ARG A 396
 OAA  A5007 (-3.9A)
OAA  A5007 (-2.9A)
CMX  A5001 (-4.9A)
OAA  A5007 (-2.9A)
 0.79A 6hxiB-2h12A:
14.5		 6hxiB-2h12A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		5 / 5 HIS A 237
ARG A 322
ASP A 371
PHE A 392
ARG A 396
 OAA  A5007 (-3.9A)
OAA  A5007 (-2.9A)
CMX  A5001 (-2.8A)
CMX  A5001 (-4.9A)
OAA  A5007 (-2.9A)
 0.77A 6hxiD-2h12A:
16.1		 6hxiD-2h12A:
21.48