SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		4 / 7 PHE A  16
VAL A  93
VAL A  37
ILE A  40
 None
 0.92A 1p7rA-2h18A:
undetectable		 1p7rA-2h18A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		5 / 12 LEU A 128
THR A  24
ILE A  67
MET A  21
SER A  90
 None
 1.20A 1xomB-2h18A:
undetectable		 1xomB-2h18A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		5 / 12 LEU A 128
THR A  24
ILE A  67
MET A  21
SER A  90
 None
 1.27A 1xoqA-2h18A:
undetectable		 1xoqA-2h18A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		5 / 12 LEU A 128
THR A  24
ILE A  67
MET A  21
SER A  90
 None
 1.25A 1xoqB-2h18A:
undetectable		 1xoqB-2h18A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		4 / 4 PHE A  36
TYR A 160
ILE A  72
LEU A  28
 None
 1.49A 3sudA-2h18A:
0.0		 3sudA-2h18A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		5 / 12 ILE A 144
GLY A 129
SER A  31
ASP A  97
VAL A  26
 None
None
GDP  A 201 (-3.4A)
None
None
 1.15A 3v8vA-2h18A:
undetectable		 3v8vA-2h18A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		4 / 8 ILE A 170
ASP A 168
ILE A 162
VAL A  93
 None
 0.76A 4ac9C-2h18A:
13.2		 4ac9C-2h18A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		4 / 8 ILE A 170
ASP A 168
ILE A 162
VAL A  93
 None
 0.74A 4acaC-2h18A:
13.4		 4acaC-2h18A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		4 / 8 ILE A 170
ASP A 168
ILE A 162
VAL A  93
 None
 0.74A 4acbC-2h18A:
12.2		 4acbC-2h18A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		4 / 6 ILE A  67
VAL A  39
PHE A  16
THR A 173
 None
 1.08A 4xe5A-2h18A:
2.8		 4xe5A-2h18A:
10.42