SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2h1c TRAFFICKING PROTEIN
B
(Neisseria
gonorrhoeae) 		5 / 12 SER A  10
ILE A   9
LEU A  30
LEU A  68
ALA A  72
 None
 1.05A 1tlsA-2h1cA:
undetectable		 1tlsA-2h1cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2h1c TRAFFICKING PROTEIN
B
(Neisseria
gonorrhoeae) 		5 / 12 SER A  10
ILE A   9
LEU A  30
LEU A  68
ALA A  72
 None
 1.13A 1tlsB-2h1cA:
undetectable		 1tlsB-2h1cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2h1c TRAFFICKING PROTEIN
B
(Neisseria
gonorrhoeae) 		5 / 12 SER A  10
ILE A   9
LEU A  30
LEU A  68
ALA A  72
 None
 1.13A 1tsnA-2h1cA:
undetectable		 1tsnA-2h1cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2h1c TRAFFICKING PROTEIN
B
(Neisseria
gonorrhoeae) 		4 / 6 PHE A 126
VAL A 118
LEU A   3
SER A  10
 None
None
MG  A 203 (-4.2A)
None
 0.99A 1wrlB-2h1cA:
undetectable		 1wrlB-2h1cA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2h1c TRAFFICKING PROTEIN
B
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  82
SER A  36
THR A   6
VAL A 118
ALA A 111
 None
MG  A 205 ( 2.5A)
None
None
None
 1.12A 2x2iA-2h1cA:
undetectable		 2x2iA-2h1cA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 2h1c TRAFFICKING PROTEIN
B
(Neisseria
gonorrhoeae) 		4 / 6 PHE A  78
GLY A 105
TYR A 106
ALA A 102
 None
 1.01A 4yshB-2h1cA:
undetectable		 4yshB-2h1cA:
17.49