SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 391
HIS A 356
ASP A 416
 None
ZN  A 601 (-3.3A)
None
 0.73A 1i9gA-2h1nA:
undetectable		 1i9gA-2h1nA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.34A 1j36A-2h1nA:
24.4		 1j36A-2h1nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
None
None
UNL  A 605 ( 4.5A)
 0.51A 1j36A-2h1nA:
24.4		 1j36A-2h1nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.33A 1j36B-2h1nA:
24.4		 1j36B-2h1nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
None
None
UNL  A 605 ( 4.5A)
 0.50A 1j36B-2h1nA:
24.4		 1j36B-2h1nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 11 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.30A 1j37A-2h1nA:
24.4		 1j37A-2h1nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		8 / 11 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.4A)
None
None
UNL  A 605 ( 4.5A)
 0.51A 1j37A-2h1nA:
24.4		 1j37A-2h1nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 11 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.30A 1j37B-2h1nA:
24.4		 1j37B-2h1nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		8 / 11 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.4A)
None
None
UNL  A 605 ( 4.5A)
 0.50A 1j37B-2h1nA:
24.4		 1j37B-2h1nA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 486
 None
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
None
 1.48A 1o86A-2h1nA:
27.2		 1o86A-2h1nA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.32A 1o86A-2h1nA:
27.2		 1o86A-2h1nA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		8 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.4A)
None
None
UNL  A 605 ( 4.5A)
 0.45A 1o86A-2h1nA:
27.2		 1o86A-2h1nA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 518
HIS A 386
SER A 387
MET A 388
GLN A 111
 None
None
ZN  A 601 (-3.5A)
None
None
 1.37A 1s2aA-2h1nA:
undetectable		 1s2aA-2h1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A 261
GLU A 253
ARG A 171
GLU A 262
ASP A 268
 None
 1.41A 1t6zA-2h1nA:
undetectable		 1t6zA-2h1nA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.92A 1v7zA-2h1nA:
undetectable		 1v7zA-2h1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.93A 1v7zB-2h1nA:
undetectable		 1v7zB-2h1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.92A 1v7zC-2h1nA:
undetectable		 1v7zC-2h1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.95A 1v7zD-2h1nA:
undetectable		 1v7zD-2h1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.95A 1v7zE-2h1nA:
undetectable		 1v7zE-2h1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.93A 1v7zF-2h1nA:
undetectable		 1v7zF-2h1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 324
GLY A 322
ILE A  63
ILE A 145
HIS A  61
 None
 1.01A 1ve3B-2h1nA:
undetectable		 1ve3B-2h1nA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A   3
TYR A  70
TYR A   8
 None
 1.02A 1x70B-2h1nA:
undetectable		 1x70B-2h1nA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		6 / 12 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.27A 2c6nA-2h1nA:
24.8		 2c6nA-2h1nA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
None
None
UNL  A 605 ( 4.5A)
 0.41A 2c6nA-2h1nA:
24.8		 2c6nA-2h1nA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		6 / 12 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.29A 2c6nB-2h1nA:
24.7		 2c6nB-2h1nA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
None
None
UNL  A 605 ( 4.5A)
 0.45A 2c6nB-2h1nA:
24.7		 2c6nB-2h1nA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A  81
ASN A 135
LEU A 199
GLU A 134
ARG A 203
 None
 1.44A 2f10A-2h1nA:
undetectable		 2f10A-2h1nA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 159
ILE A 145
PHE A 184
LEU A 192
TYR A 481
 None
 1.19A 2f7aB-2h1nA:
undetectable		 2f7aB-2h1nA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 206
PHE A 184
TYR A 188
ALA A 148
THR A  65
 None
 1.38A 2x2nD-2h1nA:
undetectable		 2x2nD-2h1nA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		6 / 11 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.27A 2x8zA-2h1nA:
25.0		 2x8zA-2h1nA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		8 / 11 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.4A)
None
None
UNL  A 605 ( 4.5A)
 0.43A 2x8zA-2h1nA:
25.0		 2x8zA-2h1nA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.29A 2x91A-2h1nA:
25.0		 2x91A-2h1nA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
None
None
UNL  A 605 ( 4.5A)
 0.43A 2x91A-2h1nA:
25.0		 2x91A-2h1nA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.91A 3a6jA-2h1nA:
undetectable		 3a6jA-2h1nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 7 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.89A 3a6jB-2h1nA:
undetectable		 3a6jB-2h1nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.89A 3a6jC-2h1nA:
undetectable		 3a6jC-2h1nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.92A 3a6jE-2h1nA:
undetectable		 3a6jE-2h1nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.88A 3a6jF-2h1nA:
undetectable		 3a6jF-2h1nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 192
TRP A 449
TYR A 196
 None
 0.90A 3aicA-2h1nA:
undetectable		 3aicA-2h1nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 192
TRP A 449
TYR A 196
 None
 0.87A 3aicB-2h1nA:
undetectable		 3aicB-2h1nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 192
TRP A 449
TYR A 196
 None
 0.88A 3aicE-2h1nA:
undetectable		 3aicE-2h1nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 192
TRP A 449
TYR A 196
 None
 0.96A 3aicF-2h1nA:
undetectable		 3aicF-2h1nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 192
TRP A 449
TYR A 196
 None
 0.87A 3aicG-2h1nA:
undetectable		 3aicG-2h1nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 192
TRP A 449
TYR A 196
 None
 0.85A 3aicH-2h1nA:
undetectable		 3aicH-2h1nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 348
ASP A 352
ASP A 405
 None
 0.94A 3iv6C-2h1nA:
undetectable		 3iv6C-2h1nA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 356
GLU A 357
HIS A 360
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
 0.17A 3kecB-2h1nA:
2.3		 3kecB-2h1nA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A  24
SER A  26
PHE A  27
ILE A  43
 None
 1.00A 3ko0S-2h1nA:
0.1		 3ko0S-2h1nA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 9 ILE A 385
ALA A 497
VAL A 548
PHE A 498
PHE A 500
 None
 1.15A 3ti1A-2h1nA:
undetectable		 3ti1A-2h1nA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 472
ALA A 433
GLU A 436
ASN A 437
MET A 440
 None
 1.28A 4a6nA-2h1nA:
undetectable		 4a6nA-2h1nA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 372
GLU A 374
PHE A 113
TYR A  91
 None
 0.97A 4a97D-2h1nA:
1.9		 4a97D-2h1nA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		6 / 11 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 None
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 1.33A 4c2pA-2h1nA:
26.5		 4c2pA-2h1nA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		8 / 11 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.4A)
None
None
UNL  A 605 ( 4.5A)
 0.50A 4c2pA-2h1nA:
26.5		 4c2pA-2h1nA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 9 GLY A 327
HIS A 356
GLU A 384
TYR A 486
TYR A 490
 None
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
None
UNL  A 605 ( 4.5A)
 0.98A 4dprA-2h1nA:
2.3		 4dprA-2h1nA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 9 HIS A 356
GLU A 357
GLU A 384
TYR A 486
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-2.2A)
None
UNL  A 605 ( 4.5A)
 0.92A 4dprA-2h1nA:
2.3		 4dprA-2h1nA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 452
ARG A 237
GLY A 424
HIS A 432
 None
 0.95A 4oltA-2h1nA:
undetectable		 4oltA-2h1nA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
UNL  A 605 ( 4.5A)
 0.57A 4r7lA-2h1nA:
7.0		 4r7lA-2h1nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 428
THR A 379
ALA A 382
ALA A 493
TYR A 228
 None
 1.41A 4u15B-2h1nA:
2.3		 4u15B-2h1nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 427
PHE A 485
ARG A 203
 None
 0.89A 4xr4B-2h1nA:
undetectable		 4xr4B-2h1nA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 5 GLY A 349
GLU A 391
HIS A 356
ASP A 416
 None
None
ZN  A 601 (-3.3A)
None
 0.82A 5c0oH-2h1nA:
undetectable		 5c0oH-2h1nA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 6 GLU A 453
ARG A 460
LEU A 468
ARG A 450
 None
 1.10A 5l6eA-2h1nA:
undetectable
5l6eB-2h1nA:
undetectable		 5l6eA-2h1nA:
18.01
5l6eB-2h1nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 324
GLN A  74
THR A  65
 None
 0.69A 5n0oA-2h1nA:
undetectable		 5n0oA-2h1nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A 328
ALA A 324
GLN A  74
THR A  65
 None
 0.69A 5n0wB-2h1nA:
undetectable		 5n0wB-2h1nA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A 328
ALA A 324
GLN A  74
THR A  65
 None
 0.78A 5n4iA-2h1nA:
undetectable		 5n4iA-2h1nA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 4 HIS A 356
HIS A 360
TYR A 486
GLU A 384
 ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
None
ZN  A 601 (-2.2A)
 1.18A 5pahA-2h1nA:
undetectable		 5pahA-2h1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 351
LEU A 400
PHE A 402
MET A 294
ASP A 283
 None
 1.07A 5x66A-2h1nA:
undetectable
5x66B-2h1nA:
undetectable		 5x66A-2h1nA:
18.18
5x66B-2h1nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		3 / 3 MET A 272
ASP A 416
ARG A 181
 None
 1.09A 5z6kA-2h1nA:
undetectable		 5z6kA-2h1nA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2h1n OLIGOENDOPEPTIDASE F
(Geobacillus
stearothermophil
us) 		4 / 6 THR A 379
LEU A 380
THR A 226
LEU A 492
 None
 1.17A 6mvxA-2h1nA:
undetectable
6mvxB-2h1nA:
2.3
6mvxC-2h1nA:
3.7		 6mvxA-2h1nA:
20.21
6mvxB-2h1nA:
20.21
6mvxC-2h1nA:
20.21