SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2h1t HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  62
HIS A  58
LEU A  59
LEU A 176
ALA A  30
 None
 1.06A 1bzfA-2h1tA:
undetectable		 1bzfA-2h1tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2h1t HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  58
LEU A  59
PHE A 109
LEU A 176
ALA A  30
 None
 1.10A 1bzfA-2h1tA:
undetectable		 1bzfA-2h1tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2h1t HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 ASP A 151
ALA A 152
ILE A 115
GLY A 175
ILE A 178
 None
 1.32A 1sguA-2h1tA:
undetectable		 1sguA-2h1tA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 2h1t HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 TRP A  53
LEU A  25
LEU A 176
THR A 112
 None
 1.08A 4bboD-2h1tA:
3.6		 4bboD-2h1tA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2h1t HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 SER A  32
SER A 107
PHE A 109
GLU A  21
 None
 1.42A 4xzkA-2h1tA:
undetectable		 4xzkA-2h1tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2h1t HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  83
GLN A 145
ASP A 101
ASP A  54
 None
 0.74A 5vlmE-2h1tA:
undetectable		 5vlmE-2h1tA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2h1t HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 134
ASP A  38
PRO A  37
 None
 0.75A 6berA-2h1tA:
undetectable		 6berA-2h1tA:
8.11