SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 8 GLY A 272
GLY A  94
PHE A   7
SER A  97
GLY A   9
 None
 1.20A 1jhqA-2h1yA:
undetectable		 1jhqA-2h1yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 7 GLU A  56
MET A 121
MET A 132
ALA A 130
 None
 1.13A 1linA-2h1yA:
undetectable		 1linA-2h1yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 LEU A 113
MET A 205
GLY A 118
ALA A  58
LEU A  39
 None
 1.00A 1r9oA-2h1yA:
undetectable		 1r9oA-2h1yA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 VAL A  96
GLY A   9
TYR A  65
GLN A 163
HIS A  91
 None
 1.25A 1vidA-2h1yA:
undetectable		 1vidA-2h1yA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 LEU A 176
GLY A 168
CYH A 199
ALA A 167
ALA A 156
 None
 1.03A 2br4A-2h1yA:
undetectable		 2br4A-2h1yA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 LEU A 176
GLY A 168
CYH A 199
ALA A 167
ALA A 156
 None
 1.02A 2br4C-2h1yA:
undetectable		 2br4C-2h1yA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 LEU A 176
GLY A 168
CYH A 199
ALA A 167
ALA A 156
 None
 1.01A 2br4D-2h1yA:
undetectable		 2br4D-2h1yA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 11 GLU A  95
ALA A 229
SER A 245
LEU A 244
VAL A 241
 None
 1.14A 2c12B-2h1yA:
2.2		 2c12B-2h1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 GLU A  95
ALA A 229
SER A 245
LEU A 244
VAL A 241
 None
 1.19A 2c12C-2h1yA:
2.1		 2c12C-2h1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 10 GLU A  95
ALA A 229
SER A 245
LEU A 244
VAL A 241
 None
 1.16A 2c12D-2h1yA:
2.1		 2c12D-2h1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 8 TYR A  59
SER A  12
SER A  92
LEU A 113
 None
 1.14A 2v0zO-2h1yA:
undetectable		 2v0zO-2h1yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		3 / 3 ARG A 117
GLU A 203
SER A  57
 None
 0.78A 2xkkA-2h1yA:
2.6
2xkkC-2h1yA:
2.6		 2xkkA-2h1yA:
17.21
2xkkC-2h1yA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 VAL A  96
GLY A   9
TYR A  65
GLN A 163
HIS A  91
 None
 1.20A 3bwyA-2h1yA:
undetectable		 3bwyA-2h1yA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 LEU A 271
GLY A 272
VAL A 276
LEU A 277
LEU A 101
 None
 1.23A 3cjtK-2h1yA:
4.0		 3cjtK-2h1yA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 7 GLN A  61
LEU A  47
VAL A  41
LEU A  93
 None
 0.93A 3g8iA-2h1yA:
undetectable		 3g8iA-2h1yA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 5 LEU A 113
LYS A 208
GLN A 210
LEU A 212
 None
 1.16A 3h5gA-2h1yA:
undetectable
3h5gB-2h1yA:
undetectable		 3h5gA-2h1yA:
7.17
3h5gB-2h1yA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 6 LEU A 113
LYS A 208
GLN A 210
LEU A 212
 None
 0.97A 3h5gB-2h1yA:
undetectable
3h5gC-2h1yA:
undetectable		 3h5gB-2h1yA:
7.17
3h5gC-2h1yA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 TYR A 254
GLY A  94
GLY A  90
LEU A  89
GLU A 270
 None
 1.13A 3vywA-2h1yA:
undetectable		 3vywA-2h1yA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 SER A 285
LEU A 284
ALA A   4
GLY A  90
LEU A   6
 None
 1.27A 4j7xB-2h1yA:
undetectable		 4j7xB-2h1yA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 5 ILE A 267
PRO A 288
TYR A 254
VAL A 258
 None
 1.33A 4s0vA-2h1yA:
3.4		 4s0vA-2h1yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 6 LEU A 191
LEU A 166
VAL A 165
PHE A 190
 None
 1.25A 4uswA-2h1yA:
undetectable		 4uswA-2h1yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 VAL A  96
GLY A   9
TYR A  65
GLN A 163
HIS A  91
 None
 1.21A 4xucA-2h1yA:
undetectable		 4xucA-2h1yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 VAL A  96
GLY A   9
TYR A  65
GLN A 163
HIS A  91
 None
 1.21A 4xudA-2h1yA:
undetectable		 4xudA-2h1yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 10 LEU A 298
ALA A 301
GLU A 300
GLY A 272
LEU A 271
 None
 1.31A 5dxbA-2h1yA:
undetectable		 5dxbA-2h1yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 8 LEU A   6
PHE A  87
ILE A 226
PHE A 268
 None
 0.83A 5eseA-2h1yA:
undetectable		 5eseA-2h1yA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		5 / 12 VAL A  96
GLY A   9
TYR A  65
GLN A 163
HIS A  91
 None
 1.23A 5fhrA-2h1yA:
0.7		 5fhrA-2h1yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE
(Helicobacter
pylori) 		4 / 8 GLN A  10
ASN A 157
ALA A 156
HIS A  91
 None
 1.18A 5km8A-2h1yA:
undetectable
5km8B-2h1yA:
undetectable		 5km8A-2h1yA:
16.89
5km8B-2h1yA:
16.89