SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.08A 1db1A-2h21A:
undetectable		 1db1A-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 5 LEU A 359
VAL A 400
ALA A 407
CYH A 404
 None
 1.03A 1mz9D-2h21A:
undetectable		 1mz9D-2h21A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.15A 1rk3A-2h21A:
undetectable		 1rk3A-2h21A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 7 SER A 428
ASP A 155
SER A 161
GLU A 167
 None
 1.04A 2cdqB-2h21A:
undetectable		 2cdqB-2h21A:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		10 / 10 GLU A  80
GLY A  81
LEU A  82
SER A 221
ARG A 222
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 None
SAM  A 801 (-3.7A)
SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-3.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.05A 2h21A-2h21A:
56.4		 2h21A-2h21A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		11 / 11 GLU A  80
GLY A  81
LEU A  82
PRO A 151
SER A 221
ARG A 222
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 None
SAM  A 801 (-3.7A)
SAM  A 801 (-3.7A)
None
SAM  A 801 (-4.3A)
SAM  A 801 (-3.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.27A 2h21B-2h21A:
50.6		 2h21B-2h21A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		11 / 11 GLU A  80
GLY A  81
LEU A  82
PRO A 151
SER A 221
ARG A 222
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 None
SAM  A 801 (-3.7A)
SAM  A 801 (-3.7A)
None
SAM  A 801 (-4.3A)
SAM  A 801 (-3.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.41A 2h21C-2h21A:
51.0		 2h21C-2h21A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.15A 2hc4A-2h21A:
undetectable		 2hc4A-2h21A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		3 / 3 ALA A 297
GLY A 435
SER A 171
 None
 0.59A 2ivuA-2h21A:
undetectable		 2ivuA-2h21A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 7 PHE A 224
LEU A 271
LEU A  97
ARG A 222
 None
None
None
SAM  A 801 (-3.3A)
 1.08A 2jn3A-2h21A:
undetectable		 2jn3A-2h21A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 8 ALA A 332
LEU A 361
LEU A 364
ILE A 380
VAL A 388
 None
 1.31A 2uxpA-2h21A:
undetectable		 2uxpA-2h21A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.13A 2zlcA-2h21A:
undetectable		 2zlcA-2h21A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 7 ILE A 436
ILE A 345
LEU A 168
LEU A 408
 None
 0.95A 3adxA-2h21A:
undetectable		 3adxA-2h21A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		3 / 3 GLU A 114
SER A 141
VAL A 142
 None
 0.58A 3eeoA-2h21A:
undetectable		 3eeoA-2h21A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 ALA A 341
LEU A 361
ILE A 318
LEU A 329
ASP A 330
 None
 0.92A 3gcsA-2h21A:
undetectable		 3gcsA-2h21A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 0.98A 3m7rA-2h21A:
undetectable		 3m7rA-2h21A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.52A 3mekA-2h21A:
10.2		 3mekA-2h21A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.53A 3qwpA-2h21A:
2.5		 3qwpA-2h21A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.76A 3qxyA-2h21A:
29.3		 3qxyA-2h21A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 GLY A  81
ASN A 242
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.60A 3qxyB-2h21A:
29.5
3qxyQ-2h21A:
undetectable		 3qxyB-2h21A:
25.81
3qxyQ-2h21A:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 GLY A  81
ASN A 242
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.53A 3rc0A-2h21A:
29.4		 3rc0A-2h21A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.72A 3rc0B-2h21A:
29.6		 3rc0B-2h21A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7B_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.65A 3s7bA-2h21A:
10.9		 3s7bA-2h21A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7F_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2
P53 PEPTIDE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.65A 3s7fA-2h21A:
10.9
3s7fI-2h21A:
undetectable		 3s7fA-2h21A:
23.60
3s7fI-2h21A:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7J_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.65A 3s7jA-2h21A:
9.7		 3s7jA-2h21A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 SER A 221
ASN A 242
HIS A 243
TYR A 287
PHE A 302
 SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
SAM  A 801 (-3.9A)
 1.17A 3s8pA-2h21A:
7.2		 3s8pA-2h21A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_SAMA1000_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		7 / 10 GLU A  80
PRO A 151
ARG A 222
ASN A 242
HIS A 243
TYR A 287
PHE A 302
 None
None
SAM  A 801 (-3.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
SAM  A 801 (-3.9A)
 0.80A 3smtA-2h21A:
31.8		 3smtA-2h21A:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TG4_A_SAMA434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 10 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.58A 3tg4A-2h21A:
9.6		 3tg4A-2h21A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.12A 3vt3A-2h21A:
undetectable		 3vt3A-2h21A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 VAL A 110
ARG A 134
SER A 141
VAL A 234
LEU A 219
 None
 1.03A 3vt7A-2h21A:
undetectable		 3vt7A-2h21A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.13A 3vt7A-2h21A:
undetectable		 3vt7A-2h21A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 SER A 221
ASN A 242
HIS A 243
TYR A 287
PHE A 302
 SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
SAM  A 801 (-3.9A)
 1.18A 4bupA-2h21A:
7.0		 4bupA-2h21A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 7 ALA A 238
PHE A 224
ALA A 253
LEU A 271
 None
 0.86A 4du2A-2h21A:
undetectable		 4du2A-2h21A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		3 / 3 ARG A 360
TRP A 381
GLY A 354
 None
 0.81A 4e7cA-2h21A:
undetectable		 4e7cA-2h21A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 ALA A  53
PHE A  57
LEU A  61
GLY A  81
LEU A  84
 None
None
None
SAM  A 801 (-3.7A)
None
 1.24A 4kykA-2h21A:
undetectable
4kykB-2h21A:
undetectable		 4kykA-2h21A:
17.95
4kykB-2h21A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YND_A_SAMA505_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 10 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.57A 4yndA-2h21A:
2.7		 4yndA-2h21A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.76A 5arfA-2h21A:
9.7		 5arfA-2h21A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARG_A_SAMA1434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.84A 5argA-2h21A:
9.2		 5argA-2h21A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.55A 5cclA-2h21A:
9.7		 5cclA-2h21A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.55A 5ccmA-2h21A:
9.5		 5ccmA-2h21A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 6 HIS A 310
GLU A 304
ALA A 431
LEU A 426
 None
 1.04A 5igiA-2h21A:
undetectable		 5igiA-2h21A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.58A 5jhnA-2h21A:
7.3		 5jhnA-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.54A 5jhnB-2h21A:
6.4		 5jhnB-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.56A 5jiyA-2h21A:
5.8		 5jiyA-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.53A 5jiyB-2h21A:
6.2		 5jiyB-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.49A 5jj0B-2h21A:
5.8		 5jj0B-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KJK_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.64A 5kjkA-2h21A:
10.8		 5kjkA-2h21A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KJL_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.65A 5kjlA-2h21A:
9.6		 5kjlA-2h21A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KJM_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.66A 5kjmA-2h21A:
10.8		 5kjmA-2h21A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KJN_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.69A 5kjnA-2h21A:
10.8		 5kjnA-2h21A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.11A 5ksgB-2h21A:
0.4		 5ksgB-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.08A 5ksnA-2h21A:
0.9		 5ksnA-2h21A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.10A 5ksnB-2h21A:
0.3		 5ksnB-2h21A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.09A 5kt8B-2h21A:
0.7		 5kt8B-2h21A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.07A 5sxsB-2h21A:
0.2		 5sxsB-2h21A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.10A 5syiB-2h21A:
0.3		 5syiB-2h21A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 8 GLU A 304
GLY A 246
GLN A 286
THR A 248
 None
 0.91A 5syjB-2h21A:
undetectable		 5syjB-2h21A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.61A 5t0kA-2h21A:
5.8		 5t0kA-2h21A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.55A 5t0kB-2h21A:
6.2		 5t0kB-2h21A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.53A 5t0mB-2h21A:
5.7		 5t0mB-2h21A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 10 GLY A  81
LEU A 240
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
None
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.33A 5tegB-2h21A:
6.1
5tegE-2h21A:
undetectable		 5tegB-2h21A:
19.73
5tegE-2h21A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.48A 5ttfA-2h21A:
5.8		 5ttfA-2h21A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.48A 5ttfB-2h21A:
6.2		 5ttfB-2h21A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.49A 5ttfC-2h21A:
6.0		 5ttfC-2h21A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.52A 5ttfD-2h21A:
7.3		 5ttfD-2h21A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.53A 5ttgA-2h21A:
6.7		 5ttgA-2h21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.55A 5ttgB-2h21A:
6.9		 5ttgB-2h21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.52A 5tuyA-2h21A:
5.8		 5tuyA-2h21A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.52A 5tuyB-2h21A:
6.7		 5tuyB-2h21A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.55A 5tuzA-2h21A:
6.8		 5tuzA-2h21A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.54A 5tuzB-2h21A:
6.9		 5tuzB-2h21A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.58A 5v37A-2h21A:
9.9		 5v37A-2h21A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.47A 5v9iA-2h21A:
6.3		 5v9iA-2h21A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.48A 5v9iB-2h21A:
6.1		 5v9iB-2h21A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 11 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.50A 5v9iC-2h21A:
6.3		 5v9iC-2h21A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.54A 5v9jA-2h21A:
7.0		 5v9jA-2h21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.54A 5v9jB-2h21A:
5.7		 5v9jB-2h21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.48A 5vscA-2h21A:
5.9		 5vscA-2h21A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.48A 5vscB-2h21A:
6.8		 5vscB-2h21A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.52A 5vsdA-2h21A:
7.0		 5vsdA-2h21A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.52A 5vsdB-2h21A:
6.7		 5vsdB-2h21A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.48A 5vseA-2h21A:
5.9		 5vseA-2h21A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.48A 5vseB-2h21A:
5.8		 5vseB-2h21A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.52A 5vsfA-2h21A:
7.1		 5vsfA-2h21A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 12 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.51A 5vsfB-2h21A:
6.7		 5vsfB-2h21A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.57A 5xxdA-2h21A:
10.0		 5xxdA-2h21A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.59A 5xxgA-2h21A:
9.9		 5xxgA-2h21A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 4 PHE A 337
LEU A 396
LEU A 355
VAL A 362
 None
 1.18A 5xxiA-2h21A:
undetectable		 5xxiA-2h21A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.55A 5xxjA-2h21A:
9.8		 5xxjA-2h21A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		6 / 12 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.56A 5yjoA-2h21A:
10.2		 5yjoA-2h21A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		4 / 6 GLU A 187
LYS A 123
LEU A 122
LEU A 191
 None
 0.82A 5yvnA-2h21A:
undetectable		 5yvnA-2h21A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.11A 6cdqA-2h21A:
0.0		 6cdqA-2h21A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.15A 6cdqB-2h21A:
0.0		 6cdqB-2h21A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E
(Pisum
sativum) 		5 / 9 GLU A 304
GLY A 246
SER A 244
GLN A 286
THR A 248
 None
 1.09A 6cfqB-2h21A:
0.0		 6cfqB-2h21A:
9.09