SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		4 / 7 LEU A 236
THR A 248
SER A 209
VAL A 205
 GOL  A 303 ( 4.9A)
None
None
None
 0.85A 1ictD-2h26A:
undetectable		 1ictD-2h26A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		5 / 12 LEU A 259
GLY A 254
ARG A 222
ASP A 253
ALA A 252
 None
 1.05A 2br4A-2h26A:
undetectable		 2br4A-2h26A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		5 / 12 LEU A 259
GLY A 254
ARG A 222
ASP A 253
ALA A 252
 None
 1.12A 2br4C-2h26A:
undetectable		 2br4C-2h26A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		5 / 12 LEU A 259
GLY A 254
ARG A 222
ASP A 253
ALA A 252
 None
 1.12A 2br4E-2h26A:
undetectable		 2br4E-2h26A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		5 / 12 ARG A 168
GLY A  56
GLY A 172
LEU A 174
GLU A  62
 NAG  A 908 (-3.9A)
None
NAG  A 908 ( 3.9A)
None
None
 1.04A 3kkzA-2h26A:
undetectable		 3kkzA-2h26A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		5 / 12 ARG A 168
GLY A  56
GLY A 172
LEU A 174
GLU A  62
 NAG  A 908 (-3.9A)
None
NAG  A 908 ( 3.9A)
None
None
 1.00A 3kkzB-2h26A:
undetectable		 3kkzB-2h26A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		5 / 11 PHE A  77
LEU A 114
VAL A 126
VAL A 158
PHE A 144
 6UL  A 312 (-4.7A)
6UL  A 312 (-4.6A)
6PL  A 311 (-4.4A)
6PL  A 311 ( 4.4A)
6UL  A 312 (-4.4A)
 1.48A 3u9fN-2h26A:
undetectable
3u9fO-2h26A:
undetectable		 3u9fN-2h26A:
22.45
3u9fO-2h26A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		3 / 3 TRP A  40
GLN A  97
THR A  26
 6UL  A 312 (-4.7A)
None
None
 1.04A 4m2xA-2h26A:
undetectable		 4m2xA-2h26A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B
(Homo
sapiens) 		4 / 7 ILE A  74
PHE A  75
TRP A  40
ASP A  41
 None
None
6UL  A 312 (-4.7A)
None
 1.35A 5nr3A-2h26A:
undetectable		 5nr3A-2h26A:
21.28