SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2h27 RNA POLYMERASE SIGMA
E FACTOR
(Escherichia
coli) 		3 / 3 LEU A 142
LEU A 138
SER A 137
 None
 0.65A 1tlmA-2h27A:
undetectable		 1tlmA-2h27A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2h27 RNA POLYMERASE SIGMA
E FACTOR
(Escherichia
coli) 		4 / 6 ALA A 177
ILE A 181
LEU A 138
ALA A 145
 None
 0.87A 3r9sA-2h27A:
undetectable		 3r9sA-2h27A:
15.73