SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h29'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 GLY A   8
HIS A  15
HIS A  18
GLY A 106
ASP A 108
 DND  A 998 (-3.2A)
None
DND  A 998 ( 4.6A)
DND  A 998 (-3.1A)
DND  A 998 (-3.0A)
 0.84A 1jzsA-2h29A:
undetectable		 1jzsA-2h29A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 GLY A   8
HIS A  18
GLY A 106
ASP A 108
GLN A 109
 DND  A 998 (-3.2A)
DND  A 998 ( 4.6A)
DND  A 998 (-3.1A)
DND  A 998 (-3.0A)
DND  A 998 (-3.4A)
 0.90A 1jzsA-2h29A:
undetectable		 1jzsA-2h29A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 ALA A  17
HIS A  18
VAL A  21
 DND  A 998 (-3.1A)
DND  A 998 ( 4.6A)
None
 0.34A 1lqtB-2h29A:
undetectable		 1lqtB-2h29A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 ALA A  17
HIS A  18
VAL A  21
 DND  A 998 (-3.1A)
DND  A 998 ( 4.6A)
None
 0.35A 1lquB-2h29A:
undetectable		 1lquB-2h29A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 HIS A  15
HIS A  18
GLY A 106
ASP A 108
VAL A 152
 None
DND  A 998 ( 4.6A)
DND  A 998 (-3.1A)
DND  A 998 (-3.0A)
None
 0.68A 1pg2A-2h29A:
5.7		 1pg2A-2h29A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 ALA A  22
VAL A  25
LEU A  29
LEU A   6
 None
 0.81A 3roxA-2h29A:
undetectable		 3roxA-2h29A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 9 LEU A   6
ILE A 145
ILE A 147
PHE A 103
VAL A 104
 None
None
None
DND  A 998 (-4.9A)
None
 1.25A 3tmzA-2h29A:
undetectable		 3tmzA-2h29A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 8 ASP A  71
ILE A  64
GLY A  70
PHE A  36
SER A 156
 None
 1.31A 4acbB-2h29A:
3.2
4acbC-2h29A:
2.9		 4acbB-2h29A:
18.26
4acbC-2h29A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 10 THR A  88
ILE A  89
LEU A 101
PHE A  92
GLY A   8
 None
None
None
None
DND  A 998 (-3.2A)
 0.97A 5mxbA-2h29A:
undetectable		 5mxbA-2h29A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 HIS A  96
SER A  99
LYS A   2
 None
 1.11A 5os7A-2h29A:
undetectable		 5os7A-2h29A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 PHE A  11
ILE A  60
ILE A  64
ILE A   4
GLU A  76
 None
None
None
None
DND  A 998 ( 4.6A)
 1.13A 5vceA-2h29A:
undetectable		 5vceA-2h29A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 HIS A  96
SER A  99
LYS A   2
 None
 1.11A 6gmdB-2h29A:
undetectable		 6gmdB-2h29A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 GLY A   9
HIS A  18
SER A 155
SER A 156
 DND  A 998 (-3.2A)
DND  A 998 ( 4.6A)
None
None
 0.23A 6jmjA-2h29A:
15.4		 6jmjA-2h29A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 7 GLY A   9
PHE A  11
HIS A  18
SER A 155
SER A 156
 DND  A 998 (-3.2A)
None
DND  A 998 ( 4.6A)
None
None
 0.24A 6jnhA-2h29A:
15.4		 6jnhA-2h29A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 GLY A   9
HIS A  18
SER A 155
SER A 156
 DND  A 998 (-3.2A)
DND  A 998 ( 4.6A)
None
None
 0.20A 6jogA-2h29A:
15.4		 6jogA-2h29A:
22.80