SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 199
TRP B 184
 None
 1.29A 1c4dC-2h2tB:
undetectable
1c4dD-2h2tB:
undetectable		 1c4dC-2h2tB:
4.38
1c4dD-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 281
TRP B 184
 None
 1.31A 1c4dC-2h2tB:
undetectable
1c4dD-2h2tB:
undetectable		 1c4dC-2h2tB:
4.38
1c4dD-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 ALA B 190
VAL B 185
TRP B 184
 None
 0.89A 1kqeA-2h2tB:
undetectable
1kqeE-2h2tB:
undetectable		 1kqeA-2h2tB:
4.57
1kqeE-2h2tB:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 ALA B 190
VAL B 185
TRP B 184
 None
 0.86A 1kqeB-2h2tB:
undetectable
1kqeD-2h2tB:
undetectable		 1kqeB-2h2tB:
4.57
1kqeD-2h2tB:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 184
ALA B 190
VAL B 185
 None
 0.88A 1kqeB-2h2tB:
undetectable
1kqeD-2h2tB:
undetectable		 1kqeB-2h2tB:
4.57
1kqeD-2h2tB:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 184
ALA B 190
VAL B 185
 None
 0.86A 1kqeA-2h2tB:
undetectable
1kqeE-2h2tB:
undetectable		 1kqeA-2h2tB:
4.57
1kqeE-2h2tB:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		4 / 8 ILE B 201
SER B 200
ASP B 283
LEU B 210
 None
 1.01A 2cdqA-2h2tB:
undetectable		 2cdqA-2h2tB:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 VAL B 281
TRP B 184
TRP B 220
 None
 1.21A 2xdcA-2h2tB:
undetectable
2xdcB-2h2tB:
undetectable		 2xdcA-2h2tB:
4.38
2xdcB-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 184
VAL B 281
TRP B 220
 None
 1.47A 2xdcA-2h2tB:
undetectable
2xdcB-2h2tB:
undetectable		 2xdcA-2h2tB:
4.38
2xdcB-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 281
TRP B 184
 None
 1.23A 2xdcA-2h2tB:
undetectable
2xdcB-2h2tB:
undetectable		 2xdcA-2h2tB:
4.38
2xdcB-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 VAL B 281
TRP B 184
TRP B 220
 None
 1.28A 2xdcC-2h2tB:
undetectable
2xdcD-2h2tB:
undetectable		 2xdcC-2h2tB:
4.38
2xdcD-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 281
TRP B 184
 None
 1.01A 2xdcC-2h2tB:
undetectable
2xdcD-2h2tB:
undetectable		 2xdcC-2h2tB:
4.38
2xdcD-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 281
TRP B 184
 None
 1.04A 2xdcE-2h2tB:
undetectable
2xdcF-2h2tB:
undetectable		 2xdcE-2h2tB:
4.38
2xdcF-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 VAL B 281
TRP B 184
TRP B 220
 None
 1.20A 2y5mA-2h2tB:
undetectable
2y5mB-2h2tB:
undetectable		 2y5mA-2h2tB:
4.38
2y5mB-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 VAL B 281
TRP B 220
TRP B 184
 None
 1.46A 2y5mA-2h2tB:
undetectable
2y5mB-2h2tB:
undetectable		 2y5mA-2h2tB:
4.38
2y5mB-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 281
TRP B 184
 None
 1.02A 2y5mE-2h2tB:
undetectable
2y5mF-2h2tB:
undetectable		 2y5mE-2h2tB:
4.38
2y5mF-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 VAL B 281
TRP B 184
TRP B 220
 None
 1.20A 2y6nA-2h2tB:
undetectable
2y6nB-2h2tB:
undetectable		 2y6nA-2h2tB:
4.38
2y6nB-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 VAL B 281
TRP B 220
TRP B 184
 None
 1.47A 2y6nA-2h2tB:
undetectable
2y6nB-2h2tB:
undetectable		 2y6nA-2h2tB:
4.38
2y6nB-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 281
TRP B 184
 None
 1.21A 2y6nA-2h2tB:
undetectable
2y6nB-2h2tB:
undetectable		 2y6nA-2h2tB:
4.38
2y6nB-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 281
TRP B 184
 None
 1.00A 2y6nC-2h2tB:
undetectable
2y6nD-2h2tB:
undetectable		 2y6nC-2h2tB:
4.38
2y6nD-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 281
TRP B 184
 None
 1.00A 2y6nE-2h2tB:
undetectable
2y6nF-2h2tB:
undetectable		 2y6nE-2h2tB:
4.38
2y6nF-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 VAL B 281
TRP B 184
TRP B 220
 None
 1.21A 3zq8A-2h2tB:
undetectable
3zq8B-2h2tB:
undetectable		 3zq8A-2h2tB:
4.38
3zq8B-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		3 / 3 TRP B 220
VAL B 199
TRP B 184
 None
 0.90A 3zq8C-2h2tB:
undetectable
3zq8D-2h2tB:
undetectable		 3zq8C-2h2tB:
4.38
3zq8D-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		4 / 5 TYR B 175
THR B 211
PHE B 177
ILE B 201
 None
 1.09A 4jx1E-2h2tB:
undetectable		 4jx1E-2h2tB:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens) 		5 / 11 GLN B 171
VAL B 199
SER B 200
ASP B 236
TYR B 175
 None
 1.45A 5jh7D-2h2tB:
undetectable		 5jh7D-2h2tB:
16.51