SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		5 / 12 PHE A 115
LEU A 207
VAL A 221
ALA A 144
ALA A 145
 None
 1.17A 1q23A-2h2wA:
undetectable
1q23B-2h2wA:
undetectable		 1q23A-2h2wA:
20.31
1q23B-2h2wA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 7 TYR A 262
CYH A 142
GLU A 236
TYR A 237
 None
 1.41A 2xytG-2h2wA:
undetectable		 2xytG-2h2wA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 7 TYR A 262
CYH A 142
GLU A 236
TYR A 237
 None
 1.37A 2xytH-2h2wA:
undetectable		 2xytH-2h2wA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 8 TYR A 237
HIS A 190
GLY A 107
ILE A 141
 None
 0.88A 2zm9A-2h2wA:
undetectable		 2zm9A-2h2wA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		3 / 3 GLU A 111
HIS A 190
HIS A 234
 None
 0.81A 3co4A-2h2wA:
undetectable		 3co4A-2h2wA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		3 / 3 GLU A 208
SER A 176
VAL A 177
 None
 0.79A 3eeoA-2h2wA:
4.1		 3eeoA-2h2wA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 7 CYH A 291
PHE A 179
PHE A 283
SER A 176
 None
 1.01A 3hggA-2h2wA:
undetectable		 3hggA-2h2wA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		3 / 3 HIS A 234
PHE A 283
PHE A 284
 None
 0.68A 3lk0D-2h2wA:
undetectable		 3lk0D-2h2wA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 6 VAL A 221
GLY A 217
GLU A 212
TYR A 219
 None
 0.83A 4dxuA-2h2wA:
undetectable		 4dxuA-2h2wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 6 GLY A 217
ALA A 173
GLU A 212
GLN A 146
 None
 1.13A 4g0uA-2h2wA:
undetectable		 4g0uA-2h2wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 6 LEU A 210
PHE A 230
TYR A 153
GLU A 206
 None
 0.94A 4pahA-2h2wA:
undetectable		 4pahA-2h2wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 6 GLU A 236
THR A 106
THR A  80
HIS A  84
 None
 1.37A 4pfjB-2h2wA:
3.7		 4pfjB-2h2wA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 7 TYR A  89
ILE A 104
HIS A  84
LEU A   9
 None
 1.02A 4xo7B-2h2wA:
undetectable		 4xo7B-2h2wA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		5 / 11 TYR A 246
ARG A 243
GLY A 166
ILE A 258
PRO A 272
 None
 1.15A 5hjiA-2h2wA:
3.0		 5hjiA-2h2wA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		3 / 3 LYS A 203
LEU A 149
ILE A 209
 None
 0.78A 5kc4A-2h2wA:
undetectable		 5kc4A-2h2wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		4 / 5 PHE A 152
THR A 125
MET A 128
ARG A 132
 None
 1.44A 5m35A-2h2wA:
undetectable		 5m35A-2h2wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		5 / 10 ILE A  48
ILE A  52
LEU A  55
HIS A  75
ILE A  85
 None
 1.40A 5vkqA-2h2wA:
undetectable
5vkqD-2h2wA:
undetectable		 5vkqA-2h2wA:
11.00
5vkqD-2h2wA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		5 / 10 HIS A  75
ILE A  85
ILE A  48
ILE A  52
LEU A  55
 None
 1.38A 5vkqA-2h2wA:
undetectable
5vkqB-2h2wA:
undetectable		 5vkqA-2h2wA:
11.00
5vkqB-2h2wA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Thermotoga
maritima) 		5 / 10 HIS A  75
ILE A  85
ILE A  48
ILE A  52
LEU A  55
 None
 1.38A 5vkqC-2h2wA:
undetectable
5vkqD-2h2wA:
undetectable		 5vkqC-2h2wA:
11.00
5vkqD-2h2wA:
11.00