SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		3 / 3 TRP A 180
VAL A 188
TRP A 214
 None
 1.09A 1c4dA-2h31A:
undetectable
1c4dB-2h31A:
undetectable		 1c4dA-2h31A:
3.04
1c4dB-2h31A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		4 / 8 THR A 300
LEU A 335
VAL A 338
THR A 343
 None
 0.81A 1dz9A-2h31A:
undetectable		 1dz9A-2h31A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		3 / 3 LEU A 368
PRO A 369
LEU A 372
 None
 0.42A 1hrkA-2h31A:
4.1		 1hrkA-2h31A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		3 / 3 LEU A 368
PRO A 369
LEU A 372
 None
 0.42A 2qd5B-2h31A:
4.5		 2qd5B-2h31A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		4 / 7 THR A 300
LEU A 335
VAL A 338
THR A 343
 None
 0.90A 3fwiA-2h31A:
undetectable		 3fwiA-2h31A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		4 / 5 LYS A  53
VAL A 252
ILE A  56
ARG A 215
 None
 1.44A 3pyyB-2h31A:
5.2		 3pyyB-2h31A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		4 / 4 VAL A 377
PHE A 386
PHE A 391
VAL A 268
 None
 1.42A 3rv5C-2h31A:
undetectable
3rv5D-2h31A:
undetectable		 3rv5C-2h31A:
13.68
3rv5D-2h31A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		4 / 6 SER A 405
LEU A 407
HIS A 167
THR A 409
 None
 1.45A 3thrB-2h31A:
undetectable		 3thrB-2h31A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		3 / 3 LEU A 368
PRO A 369
LEU A 372
 None
 0.41A 3w1wB-2h31A:
3.9		 3w1wB-2h31A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		4 / 8 SER A 400
SER A 179
HIS A 396
ILE A  64
 None
 1.29A 4ms4A-2h31A:
9.1		 4ms4A-2h31A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		4 / 4 CYH A 288
PHE A 291
ILE A 348
GLY A 382
 None
 1.42A 5hesB-2h31A:
3.9		 5hesB-2h31A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2h31 MULTIFUNCTIONAL
PROTEIN ADE2
(Homo
sapiens) 		5 / 8 VAL A 268
ILE A 293
ALA A 388
PHE A 325
VAL A 326
 None
 1.29A 5l94A-2h31A:
undetectable		 5l94A-2h31A:
23.00