SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2h32 IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 GLY H  35
ALA H  79
THR H  58
SER H  71
ALA H  72
 None
 1.43A 1gtnO-2h32H:
1.5
1gtnP-2h32H:
undetectable		 1gtnO-2h32H:
15.28
1gtnP-2h32H:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2h32 IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens) 		5 / 9 GLY H  35
ALA H  79
THR H  58
SER H  71
ALA H  72
 None
 1.45A 1gtnQ-2h32H:
undetectable
1gtnR-2h32H:
undetectable		 1gtnQ-2h32H:
15.28
1gtnR-2h32H:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2h32 IMMUNOGLOBULIN IOTA
CHAIN
IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  38
PRO A  46
TYR A  95
TYR H  95
 None
 0.70A 2oldA-2h32A:
12.4
2oldB-2h32A:
12.5		 2oldA-2h32A:
24.66
2oldB-2h32A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2h32 IMMUNOGLOBULIN IOTA
CHAIN
IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR H  95
TYR A  38
PRO A  46
TYR A  95
 None
 0.74A 2oldA-2h32H:
11.6
2oldB-2h32H:
16.5		 2oldA-2h32H:
34.27
2oldB-2h32H:
34.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2h32 IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 ALA H 185
ALA H 149
ALA H 186
SER H 177
TYR H 184
 None
 1.32A 2r2vC-2h32H:
undetectable
2r2vF-2h32H:
undetectable
2r2vG-2h32H:
undetectable		 2r2vC-2h32H:
10.09
2r2vF-2h32H:
10.09
2r2vG-2h32H:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2h32 IMMUNOGLOBULIN IOTA
CHAIN
(Homo
sapiens) 		4 / 8 HIS A  28
VAL A   3
GLY A  99
ALA A 100
 None
 0.95A 2xh9A-2h32A:
undetectable		 2xh9A-2h32A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2h32 IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 LEU H  86
SER H  85
LEU H  81
TYR H  94
 None
 0.83A 3ln1A-2h32H:
undetectable		 3ln1A-2h32H:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2h32 IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 VAL H 190
SER H 171
LEU H 192
 None
 0.47A 3n8xA-2h32H:
undetectable		 3n8xA-2h32H:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2h32 IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 GLN H   3
GLU H   1
LYS H   1
 None
 0.93A 3su9A-2h32H:
undetectable		 3su9A-2h32H:
19.63