SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  73
TYR A 154
PHE A 152
HIS A  75
 None
 0.99A 2ha4A-2h34A:
undetectable		 2ha4A-2h34A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 144
LEU A 155
HIS A 137
 None
 0.83A 2q6fB-2h34A:
undetectable		 2q6fB-2h34A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A  28
GLY A  23
GLY A  25
 None
 0.41A 3bogC-2h34A:
undetectable		 3bogC-2h34A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 126
LEU A 201
VAL A 140
ILE A 119
LEU A 101
 None
 1.36A 3fl9H-2h34A:
undetectable		 3fl9H-2h34A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 201
LEU A 267
ARG A 121
 None
 0.76A 3hcnB-2h34A:
undetectable		 3hcnB-2h34A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  28
VAL A  30
ALA A  43
LYS A  45
VAL A  77
ASP A 157
 None
 0.83A 3v5wA-2h34A:
10.8		 3v5wA-2h34A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 198
ARG A 260
TYR A 199
TYR A 215
 None
 1.13A 5iwuA-2h34A:
6.1		 5iwuA-2h34A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		6 / 10 GLY A  23
VAL A  30
ALA A  43
MET A  93
LEU A  95
VAL A 156
 None
 1.21A 5lw1E-2h34A:
19.3		 5lw1E-2h34A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  23
VAL A  30
ALA A  43
MET A  93
LEU A  95
 None
 0.70A 5lw1H-2h34A:
19.5		 5lw1H-2h34A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A  83
ASP A  81
ILE A  79
 None
 0.61A 6dgxB-2h34A:
undetectable		 6dgxB-2h34A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 246
PHE A 245
ILE A 249
LEU A 205
PRO A 113
 None
 1.21A 6fgcA-2h34A:
undetectable		 6fgcA-2h34A:
14.56