SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 9 GLY X 148
THR X 135
GLY X 107
ALA X 114
ILE X 111
 None
 1.19A 1gtfD-2h3gX:
undetectable
1gtfE-2h3gX:
undetectable		 1gtfD-2h3gX:
16.15
1gtfE-2h3gX:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 7 LEU X  47
LEU X  42
MET X  28
LEU X  14
 None
 1.05A 1kt3A-2h3gX:
undetectable		 1kt3A-2h3gX:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 LEU X 223
GLY X 191
GLY X 195
TYR X 196
ILE X 173
 None
 1.09A 1p91B-2h3gX:
undetectable		 1p91B-2h3gX:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 7 PHE X 130
THR X 151
VAL X 204
ILE X 227
 None
 0.91A 1t87B-2h3gX:
undetectable		 1t87B-2h3gX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 4 SER X 228
ILE X 227
VAL X 128
THR X 242
 None
 1.11A 1u70A-2h3gX:
undetectable		 1u70A-2h3gX:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 9 PHE X 130
THR X 151
VAL X 204
GLY X 202
ILE X 227
 None
 1.01A 2a1oB-2h3gX:
undetectable		 2a1oB-2h3gX:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		3 / 3 SER X  63
ASP X 129
CYH X 137
 None
 1.08A 2br4E-2h3gX:
undetectable		 2br4E-2h3gX:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 8 TYR X 100
GLY X 107
THR X 135
ILE X 150
 None
 0.79A 2f9wA-2h3gX:
23.1
2f9wB-2h3gX:
23.2		 2f9wA-2h3gX:
24.57
2f9wB-2h3gX:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 8 PHE X 130
THR X 151
VAL X 204
ILE X 227
 None
 0.94A 2qbmA-2h3gX:
undetectable		 2qbmA-2h3gX:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 7 LEU X  14
LEU X   5
PHE X   3
LEU X  46
 None
 0.94A 2vq5B-2h3gX:
undetectable		 2vq5B-2h3gX:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 GLY X 222
LEU X  22
ASP X   6
ASP X 109
ASP X 129
 None
None
EDO  X 501 (-3.6A)
None
None
 1.34A 2vqyA-2h3gX:
undetectable		 2vqyA-2h3gX:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 6 LEU X  86
ILE X  92
ILE X 139
LEU X 241
 None
 0.96A 2xkwB-2h3gX:
undetectable		 2xkwB-2h3gX:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 10 VAL X  13
ASP X 109
ILE X  69
PRO X  68
THR X 242
 EDO  X 501 (-4.3A)
None
None
None
None
 1.27A 3clbD-2h3gX:
undetectable		 3clbD-2h3gX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 LEU X 246
ALA X  12
GLY X   8
SER X  63
LEU X  14
 None
None
EDO  X 501 (-3.6A)
None
None
 1.15A 3ou6B-2h3gX:
undetectable		 3ou6B-2h3gX:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 LEU X 246
ALA X  12
GLY X   8
SER X  63
LEU X  14
 None
None
EDO  X 501 (-3.6A)
None
None
 1.17A 3ou7A-2h3gX:
undetectable		 3ou7A-2h3gX:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 LEU X 246
ALA X  12
GLY X   8
SER X  63
LEU X  14
 None
None
EDO  X 501 (-3.6A)
None
None
 1.12A 3ou7B-2h3gX:
undetectable		 3ou7B-2h3gX:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 LEU X 246
ALA X  12
GLY X   8
SER X  63
LEU X  14
 None
None
EDO  X 501 (-3.6A)
None
None
 1.17A 3ou7D-2h3gX:
undetectable		 3ou7D-2h3gX:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 8 ALA X 219
VAL X 128
ASP X 129
LEU X 223
 None
 0.75A 3roxA-2h3gX:
undetectable		 3roxA-2h3gX:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 5 ARG X  32
THR X  10
GLU X  29
THR X  30
 None
 1.39A 4eahA-2h3gX:
0.0
4eahE-2h3gX:
0.0
4eahG-2h3gX:
11.9		 4eahA-2h3gX:
18.07
4eahE-2h3gX:
18.07
4eahG-2h3gX:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 6 LEU X  73
MET X  28
LEU X  14
VAL X  57
 None
 1.03A 4okbA-2h3gX:
undetectable		 4okbA-2h3gX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		3 / 3 ASP X 109
LYS X 244
LEU X  22
 None
 0.97A 4ptjA-2h3gX:
undetectable		 4ptjA-2h3gX:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 7 LEU X  73
MET X  76
ALA X  12
MET X  28
 None
 0.95A 4rjdB-2h3gX:
undetectable		 4rjdB-2h3gX:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 VAL X  43
LEU X  47
MET X   1
VAL X  57
LEU X   5
 None
 1.12A 4rrwA-2h3gX:
undetectable		 4rrwA-2h3gX:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 VAL X  43
LEU X  47
MET X   1
VAL X  57
LEU X   5
 None
 1.14A 4rrwB-2h3gX:
undetectable		 4rrwB-2h3gX:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 VAL X  43
LEU X  47
MET X   1
VAL X  57
LEU X   5
 None
 1.12A 4rrzA-2h3gX:
undetectable		 4rrzA-2h3gX:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		5 / 12 VAL X  43
LEU X  47
MET X   1
VAL X  57
LEU X   5
 None
 1.14A 4rrzB-2h3gX:
undetectable		 4rrzB-2h3gX:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 5 PHE X  54
PHE X   3
PHE X  81
VAL X  43
 None
 1.04A 5a1rA-2h3gX:
undetectable		 5a1rA-2h3gX:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 8 ARG X  27
GLU X  29
GLY X   8
THR X 132
 EDO  X 501 (-4.0A)
None
EDO  X 501 (-3.6A)
None
 0.99A 5syjB-2h3gX:
undetectable		 5syjB-2h3gX:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		3 / 3 LYS X 182
SER X 186
SER X 177
 None
 1.12A 6gbfA-2h3gX:
undetectable		 6gbfA-2h3gX:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2h3g BIOSYNTHETIC PROTEIN
(Bacillus
anthracis) 		4 / 8 GLY X 195
GLY X 153
SER X 157
ALA X 160
 None
 0.74A 6hu9H-2h3gX:
undetectable
6hu9e-2h3gX:
undetectable		 6hu9H-2h3gX:
18.03
6hu9e-2h3gX:
19.78