SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		5 / 7 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  68
 None
 0.74A 1th6A-2h4cB:
19.1		 1th6A-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		4 / 7 HIS B  48
TYR B  52
PRO B  68
LYS B  69
 None
 1.16A 1th6A-2h4cB:
19.1		 1th6A-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 2h4c PHOSPHOLIPASE A2-III
(Daboia
siamensis) 		5 / 7 HIS A  48
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
 0.90A 1th6A-2h4cA:
20.1		 1th6A-2h4cA:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		5 / 7 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  68
 None
 0.73A 2armA-2h4cB:
19.1		 2armA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		4 / 7 HIS B  48
TYR B  52
PRO B  68
LYS B  69
 None
 1.16A 2armA-2h4cB:
19.1		 2armA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-III
(Daboia
siamensis) 		5 / 7 HIS A  48
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
 0.90A 2armA-2h4cA:
20.1		 2armA-2h4cA:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		5 / 11 ILE B   9
TYR B  25
GLY B  30
PHE B 106
TYR B 113
 None
 0.60A 2azyA-2h4cB:
14.9		 2azyA-2h4cB:
36.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		4 / 6 ALA B   6
HIS B  48
ASP B  49
TYR B  52
 None
 1.07A 2dpzA-2h4cB:
19.5		 2dpzA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		4 / 6 LEU B   2
HIS B  48
ASP B  49
TYR B  52
 None
 0.69A 2dpzA-2h4cB:
19.5		 2dpzA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-III
(Daboia
siamensis) 		4 / 6 ALA A  18
HIS A  48
ASP A  49
TYR A  52
 None
 0.77A 2dpzA-2h4cA:
20.4		 2dpzA-2h4cA:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-III
(Daboia
siamensis) 		3 / 3 ASP A  49
TYR A  52
LYS A  69
 None
 0.75A 2othA-2h4cA:
20.1		 2othA-2h4cA:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		4 / 5 HIS B  48
ASP B  49
TYR B  52
PRO B  68
 None
 0.42A 3fo7A-2h4cB:
19.1		 3fo7A-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-III
(Daboia
siamensis) 		4 / 5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
 0.79A 3fo7A-2h4cA:
20.2		 3fo7A-2h4cA:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		4 / 5 HIS B  48
ASP B  49
TYR B  52
PRO B  68
 None
 0.43A 3h1xA-2h4cB:
19.2		 3h1xA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2h4c PHOSPHOLIPASE A2-III
(Daboia
siamensis) 		4 / 5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
 0.79A 3h1xA-2h4cA:
20.2		 3h1xA-2h4cA:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		5 / 9 LEU B   2
PHE B   5
ILE B   9
GLY B  30
HIS B  48
 None
 0.50A 3oshA-2h4cB:
17.6		 3oshA-2h4cB:
42.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B602_1
(SERUM ALBUMIN)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		5 / 9 VAL B  47
ALA B 102
PHE B 106
TYR B 113
TYR B  25
 None
 1.41A 4lb2B-2h4cB:
undetectable		 4lb2B-2h4cB:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2h4c PHOSPHOLIPASE A2-II
(Daboia
siamensis) 		4 / 5 TYR B  75
ILE B  82
LEU B   2
PHE B   5
 None
 0.79A 5kmdC-2h4cB:
undetectable
5kmdD-2h4cB:
undetectable		 5kmdC-2h4cB:
14.29
5kmdD-2h4cB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2h4c PHOSPHOLIPASE A2-III
(Daboia
siamensis) 		4 / 8 TYR A  22
GLY A  30
ILE A  24
ASP A  42
 None
 0.80A 6ag0A-2h4cA:
undetectable		 6ag0A-2h4cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2h4c PHOSPHOLIPASE A2-III
(Daboia
siamensis) 		4 / 8 TYR A  22
GLY A  30
ILE A  24
ASP A  42
 None
 0.81A 6ag0C-2h4cA:
undetectable		 6ag0C-2h4cA:
21.01